Paraxanthine hmoov

Noj qab haus huv^®yog aChaw tsim tshuaj paus thiab tsum ntawm paraxanthine hmoov (1,7-DMX). Paraxanthine yog lub ntsiab metabolite ntawm caffeine hauv tib neeg lub cev. Nws tsis yog ncaj qha los ntawm cov nroj tsuag, tab sis yog tsim los ntawm kev tawg ntawm caffeine los ntawm cytochrome P450 enzymes (tsuas yog CYP1A2) hauv daim siab. Raws li purine alkaloid, nws nthuav tawm cov txiaj ntsig zoo tshaj plaws: cov kev tshawb fawb tau pom tias nws muaj cov teebmeem neuroprotective tseem ceeb, tiv thaiv dopaminergic neurons los ntawm activating renin receptor channels thiab nce glutathione qib hauv neurons, yog li qhia tau tias muaj peev xwm txo tau cov kab mob neurodegenerative xws li Parkinson's disease; Nyob rau tib lub sij hawm, nws kuj yog ib tug zoo dua central paj hlwb stimulant duacaffeine, txhim kho lub cev muaj zog ua haujlwm thiab kev paub txog kev ua haujlwm nrog tsawg dua kev phiv. Peb muaj97% 98% paraxanthine hmoov. Tiv tauj pebntawminfo@kintaibio.com.

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Kev npaj cov khoom pib thiab Acylation Reaction
Lub synthesis pib nrog cov khoom tseem ceeb pib,ethyl 4 -amino-1-methyl-1H-imidazole-5-carboxylate, uas yog muag nyob rau hauv siab purity (Ntau tshaj los yog sib npaug rau 98%). Cov tshuaj no yog reacted nrog methylcarbamoyl chloride nyob rau hauv ib qho anhydrous organic hnyav xws li dichloromethane nyob rau hauv kev tswj qhov kub thiab txias. methylcarbamoyl chloride ua raws li tus neeg sawv cev acylating, tawm tsam thawj pawg amino ntawm lub nplhaib imidazole. Cov tshuaj tiv thaiv no tshwm sim los ntawm kev hloov pauv ntawm nucleophilic acyl, xaiv qhia txog carbamoyl sab saw mus rau imidazole core. Cov tshuaj tiv thaiv yog saib xyuas los ntawm nyias - txheej chromatography kom ua tiav cov kev hloov pauv ntawm cov khoom pib, feem ntau xav tau ob peb teev nrog nplawm ntawm chav tsev kub lossis txias me ntsis los tswj cov exothermicity.

Kev rho tawm thiab ua kom huv ntawm Acylation Intermediate
Tom qab cov tshuaj tiv thaiv acylation tiav lawm, qhov sib tov yog ua kua -kua extraction los cais cov crude nruab nrab. Cov txheej txheem organic yog sib cais thiab ntxuav ua ntu zus nrog dilute acid, dej, thiab dilute puag kom tshem tawm cov khoom pib tsis muaj kev cuam tshuam thiab cov khoom lag luam. Tom qab ntawd cov tshuaj yog qhuav dhau anhydrous sodium sulfate thiab concentrated nyob rau hauv txo siab siv ib tug teb evaporator. Lub resulting crude khoom yog purified los ntawm yooj yim recrystallization los ntawm ethanol. Cov kauj ruam crystallization no zoo heev thiab tshem tawm qhov xav tau ntawm kem chromatography, ua cov ntshiab amide nruab nrab raws li cov khoom siv crystalline nrog cov txiaj ntsig zoo rov qab.

Cyclization Reaction rau Form Paraxanthine
Cov purified intermediate yog raug rau intramolecular cyclization siv cov aqueous sodium hydroxide tov. Cov tshuaj tiv thaiv sib tov yog nplawm ntawm chav tsev kub lossis nrog cua sov (40-50 degree) rau ob peb teev. Lub alkaline ib puag ncig deprotonates cov amide nitrogen, hloov nws mus rau hauv ib tug muaj zog nucleophile uas tawm tsam ester carbonyl pawg nyob rau hauv tib molecule. Qhov no nucleophilic ntxiv-kev tshem tawm mechanism kaw lub nplhaib thib ob ntawm purine system, tsim cov yam ntxwv xanthine pob txha. Kev nce qib ntawm cyclization yog saib xyuas los ntawm HPLC kom paub meej tias ua tiav kev noj nruab nrab thiab ua kom cov txiaj ntsig zoo tshaj plaws ntawm paraxanthine.

Kev rho tawm thiab nruab nrab ntawm cov khoom Crude
Thaum cov tshuaj tiv thaiv cyclization ncav cuag tiav, cov tshuaj tiv thaiv sib tov yog txias rau chav sov yog tias siv cua sov. Cov tshuaj yog ua tib zoo neutralized los ntawm kev ntxiv dilute hydrochloric acid dropwise thaum stirring. Raws li pH ze rau nruab nrab (kwv yees 6-7),paraxanthineprecipitates los ntawm cov tshuaj raws li ib tug dawb mus tawm -dawb khoom vim nws cov dej tsis zoo solubility. Cov khoom nyoos yog sau los ntawm lub tshuab nqus tsev los ntawm Büchner funnel thiab ntxuav kom huv si nrog dej deionized kom tshem tawm cov ntsev inorganic, residual puag, thiab lwm yam dej-soluble impurities. Cov khoom damp yog ib nrab qhuav los ntawm huab cua nqus ntawm lub lim.

Recrystallization thiab zaum kawg ziab
Covparaxanthine hmoovyog purified rau qib kws tshuaj los ntawm recrystallization. Cov khoom yog yaj nyob rau hauv qhov tsawg kawg nkaus ntim ntawm kub ethanol los yog ethanol - dej sib tov (feem ntau 70:30 v/v), thiab cov tshuaj kub yog lim kom tshem tawm tej yam insoluble particulates. Thaum txias txias rau chav sov,ntshiab paraxanthinecrystallizes tawm ib yam nkaus li- tsim cov crystals thaum impurities tseem nyob hauv niam cawv. Cov muaju yog sau los ntawm kev pom thiab ziab hauv qhov cub nqus tsev ntawm 60-70℃kom txog thaum qhov hnyav tas li. Qhov kev sib txuas ob-kauj ruam no ua tiav tag nrho cov txiaj ntsig ntawm kwv yees li 80% nrog cov khoom purity tshaj98%, ua cov txheej txheem haum rau kilogram-scale industrial ntau lawm.

Paraxanthine thiab astaxanthinyog ob yam khoom siv bioactive nrog ntau yam tshuaj sib txawv,mechanisms ntawm kev ua, thiab apps.1,7-DMXbelongs rau methylxanthine alkaloid chav kawm thiab yog lub ntsiab metabolite ntawm caffeine nyob rau hauv tib neeg lub cev. Nws cov txheej txheem tseem ceeb yog raws li lub hauv paus ntawm lub paj hlwb stimulant, nrog rau qhov pib sai thiab muaj kev phiv tsawg dua li caffeine.AstaxanthinNtawm qhov tod tes, yog carotenoid, feem ntau muab los ntawm Haematococcus pluvialis. Nws yog ib tug muaj zog rog-soluble antioxidant uas muaj peev xwm embed nws tus kheej nyob rau hauv cell membranes neutralize dawb radicals thiab inhibit inflammatory txoj kev.

Raws li cov kev sib txawv no, lawv daim ntawv thov sib txawv sharply:Paraxanthinefeem ntau yog siv rau hauv cov xwm txheej uas xav tau kev paub txog kev paub thiab kev ua tau zoo tam sim ntawd, xws li kev paub ntxiv, ua ntej- cov qauv kev ua haujlwm, thiabtswj qhov hnyavcov khoom, aiming muab lub zog khov kho thaum tsis txhob ntshai;astaxanthin tshuaj, txawm li cas los xij, tsom rau kev saib xyuas kev noj qab haus huv ntev ntev thiab siv dav hauv qhov ncauj kev zoo nkauj, tiv thaiv - laus, qhov muag, thiab cov khoom noj qab haus huv sib koom ua ke, tiv thaiv daim tawv nqaij, retina, thiab kab mob plawv los ntawm kev tshem tawm oxidative tsis tu ncua. Nyob rau hauv luv luv, paraxanthine lub hom phiaj los txhawb kev ua tau zoo tam sim ntawd, thaum astaxanthin tsom rau ntev - tiv thaiv thiab kev tiv thaiv.

paraxanthine rau addh

Paraxanthine, ib qho tseem ceeb metabolite ntawm caffeine, tau pom muaj peev xwm tseem ceeb hauv kev txhim kho kev txawj ntse uas cuam tshuam nrogADHDnyob rau hauv cov neeg laus. Muab piv rau cov tshuaj caffeine ib txwm muaj, paraxanthine zoo zam kev ntxhov siab, ntxhov siab, thiab pw tsaug zog cuam tshuam nrog caffeine.Paraxanthine hmoovmuab kev ruaj ntseg thiab kev txawj ntse ntau dua li caffeine, muaj peev xwm txhim kho kev mloog zoo los ntawm kev txo qis kev xav mus ncig thiab txhim kho kev ua haujlwm ntawm lub hlwb lub neej ua haujlwm network. Nws kuj tseem txhim kho kev nco thiab lub hlwb- tau txais cov txiaj ntsig neurotrophic (BDNF) ntau dua li caffeine, muab kev txhawb nqa theoretical rau kev tshawb nrhiav ntxiv ntawm nws daim ntawv thov hauvKev kho ADHD.

paraxanthine rau ntshav siab

Cov teebmeem ntawmparaxanthine rau ntshav siabyog qhov nyuaj, nrog cov kev tshawb fawb uas twb muaj lawm qhia tias nws yuav ua rau muaj kev sib txawv ntawm kev tswj hwm ntawm systolic thiab diastolic ntshav siab. Qhov kev tswj hwm bidirectional no yuav cuam tshuam nrog paraxanthine lub siab xav ua kom ua rau adenosine receptor antagonist. Zuag qhia tag nrho, cov teebmeem ntawmparaxanthine hmoovntawm cov ntshav siab pom cov koob tshuaj- nyob ntawm tus yam ntxwv thiab ntau yam, muaj peev xwm tiv thaiv cov ntshav siab, tab sis nws cov nyhuv ntawm diastolicntshav siabxav tau kev tshawb nrhiav ntxiv.

paraxanthine rau poob phaus

1,7-DMXyog qhov zoo kawg nkaus hauv kev txhawb nqatswj qhov hnyav. Raws li lub ntsiab nquag metabolite ntawm caffeine, paraxanthine tuaj yeem ua kom cov metabolism hauv so kom zoo, ua rau lub cev hlawv ntau calories thaum so. Tib lub sijhawm, nws txhawb kev tawg ntawm triglycerides hauv cov ntaub so ntswg adipose rau hauv cov roj ntsha dawb thiab txhim kho oxidation thiab siv cov fatty acids no thaum lub sijhawm ua haujlwm lossis ua haujlwm txhua hnub, yog li hloov lub cev ntawm cov rog raws li lub zog nyiam. Tsis tas li ntawd,paraxanthinekuj muaj kev tshaib kev nqhis -txo cov nyhuv, pab kom txo tau tag nrho cov calories kom tsawg, uas yog ib qho tseem ceeb rau lub sij hawm ntev - tswj qhov hnyav.

Paraxanthine rau AHD

Paraxanthine rau ntshav siab

Paraxanthine rau poob phaus

paraxanthine ntxiv

CovKev siv cov tshuaj paraxanthinehauv kev lag luam ntxiv kev noj qab haus huv tau txais kev saib xyuas ntxiv, feem ntau tsom rau kev paub txog kev txawj ntse thiabtswj qhov hnyav. Hauv kev paub txog kev noj qab haus huv, kev tshawb fawb tau lees paub nws lub peev xwm los txhim kho kev mloog, kev nco, thiab cov tshuaj tiv thaiv ceev. Cov kev sim tshuaj tam sim no tab tom tshawb nrhiav qhov cuam tshuam ntawm kev sib xyaw L-theanine thiab paraxanthine ntawm kev txhim kho kev paub tsis zoo hauv cov neeg lausnrog ADHD. Hauv kev tswj qhov hnyav, paraxanthine pab kom poob phaus los ntawm kev ua kom lipolysis, nce kev siv hluav taws xob, thiab txo qis qab los noj mov. Cov ntaub ntawv patent kuj qhia meej meej tias nws qhov ua tau zoo hauv kev tsim cov thermogenesis thiab txhawb lipolysis. Cov ntaub ntawv tseem ceeb muaj xws li paraxanthine capsules, thiab lwm yam.

Paraxanthine dej qab zib

Paraxanthine haustau dhau los ua ib qho kev taw qhia tseem ceeb hauv kev ua haujlwm dej haus. Tam sim no, qee lub zog haus dej haus thiab cov khoom kas fes tau pib siv los hloov lossisntxiv rau caffeine. Ntawm qhov tod tes, nws muaj cov dej solubility zoo dua thiab qis dua iab dua li caffeine, ua rau cov dej haus saj tau zoo dua thiab muab cov qauv yooj yim dua. Ntawm qhov tod tes, nws txoj hauv kev metabolic muab rau cov neeg siv khoom muaj kev paub zoo dua qub. Hais txog hom khoom,paraxanthinetau siv rau ntau pawg, suav nrog npaj tau-- haus kas fes, espresso,haus dej haus cawv nrog paraxanthine, dej haus ua kis las, thiab dej cawv.

Hauv Teb Chaws Asmeskas, ib lub tuam txhab tau txaisGRAS (Feem ntau lees paub tias muaj kev nyab xeeb)raws li txoj cai rau nws cov khoom muaj npe paraxanthine, tso cai rau nws siv rau hauv cov dej haus, decaffeinated kas fes, hmoov, khoom noj khoom haus bar, thiab lwm yam khoom noj thiab dej haus ntawm ibkoob tshuaj ntau tshaj 300 mg rau ib zaug. CovFDARaws li lub koom haum tswj hwm hauv Teb Chaws Asmeskas, muaj kev saib xyuas ntawm GRAS ntawv pov thawj, uas yog raws li kev tshawb fawb dav dav lees paub nws txoj kev nyab xeeb.In EU, European Food Safety Authority (EFSA) yog ntsuas paraxanthine li acov khoom noj tshiab tshiab, pom zoo nyob rau hauv nws qhov kev xav anoj txhua hnub ntawm 200 mgnyob rau hauv kev noj haus pab rau cov neeg laus nruab nrab.

Raws li cov kev tshawb fawb soj ntsuam uas twb muaj lawm thiab kev ntsuam xyuas toxicological,paraxanthineua kom pom kev nyab xeeb zoo thiab kam rau ua ntawm cov tshuaj noj, nrog rau nwskev mob tshwm simprofile feem ntau superior rau cov pa caffeine. Piv nrog rau caffeine, paraxanthine ua rau muaj kev pheej hmoo tsawg ntawm cov hlab plawv, plab hnyuv, pw tsaug zog, thiab kev ntxhov siab- cuam tshuam txog kev mob tshwm sim, feem ntau vim nws luv dua hauv vivo ib nrab-lub neej thiab cov khoom siv tshuaj tshwj xeeb- kev tshawb fawb tau pom tiasparaxanthinemuaj qhov cuam tshuam me me ntawm cov ntshav siab diastolic dua li caffeine thiab tuaj yeem muaj kev tiv thaiv -kev ntxhov siab.

Xaiv pebparaxanthine hmoovmuab kev daws teeb meem rau koj nrog kev sib xyaw ua ke zoo tshaj plaws, cov ntawv pov thawj pom zoo, thiab kev pabcuam hloov tau. Peb cov khoom raug kuaj xyuas nruj kom ntseeg tau tias kev huv huv thiab kev ywj pheej los ntawm kev kis kab mob, ua rau cov neeg ncaws pob thiab ua tau zoo -cov neeg siv khoom muaj kev thaj yeeb nyab xeeb. Tsis tas li ntawd, peb cov hmoov muaj qhov zoo xws li qis iab thiab solubility zoo dua, yooj yim rau kev koom ua ke rau hauv ntau yam khoom siv. Qhov tseem ceeb, peb muab ntau daim ntawv pov thawj thoob ntiaj teb suav nrog Halal, Vegan, thiab Tsis yog-GMO, thiab muab cov kev pabcuam hloov kho kom haum raws li koj xav tau, suav nrog cov ntim tshwj xeeb, kev sib xyaw ua ke, thiab kev txhawb nqa OEM, pab koj cov khoom muag hauv kev sib tw ua lag luam.Tiv tauj pebntawminfo@kintaibio.com.

Cim npe nrov: Tuam Tshoj paraxanthine hmoov manufacturers, lwm tus neeg, Hoobkas