Apigenin hmoov

Noj qab haus huv^®yog aChaw tsim tshuaj paus thiab tsum ntawm apigenin. Chemically hu ua4', 5,7-trihydroxyflavone, apigenin yog flavonoid tshwm sim nyob rau hauv cov txiv hmab txiv ntoo, zaub, thiab cov nroj tsuag thoob plaws cheeb tsam sov thiab chaw sov, nrog rau cov ntsiab lus tshwj xeeb hauvcelery, parsley, thiab chamomile. Raws li cov nroj tsuag - muab tau los ntawm bioactive polyphenol, apigenin ua kom pom dav dav ntawm cov tshuaj muaj peev xwm, suav nrog cov tshuaj antioxidant tseem ceeb, tiv thaiv - mob, thiab cov teebmeem neuroprotective, nrog rau cov txiaj ntsig zoo rau cov hlab plawv. Peb muabapigenin hmoovnyob rau hauv ntau yam specifications thiab los ntawm ntau qhov chaw.Yuav apigenin hmoov, Thovtiv tauj pebntawm info@kintaibio.com.

Celery

Chamomile

naringin

Celeryyog qhov ncaj ncees tshaj plawsqhov chaw ntawm apigenin; peb cov extract yog muab los ntawm siab - zoo celery nplooj.Chamomileua hauj lwm ua lwm yam raw khoom rau pebapigenin uantau lawm. Tsis tas li ntawd, semi-synthesis ntawm apigenin los ntawmnaringinyog ib txoj hauv kev zoo rau kev lag luam- nplai ntau lawm; Cov txheej txheem no siv naringin ua cov khoom pib thiab siv tshuaj lom neeg cov tshuaj tiv thaiv, xws li iodine-kev kho dehydrogenation,synthesize apigenin, yielding ib yam khoom nrog dhau 98% purity thiab high yield tag nrho.

Noj qab haus huv^®siv ntuj pomelo tev raws li cov khoom siv raw; Tom qab pulverization thiab tshuaj ntsuam xyuas, cov khoom siv reflux extraction siv ethanol - dej tov. Cov khoom xyaw nquag yog concentrated, ua raws li ethyl acetate extraction thiab recrystallization kom tawm losnaringin. Tom qab ntawd, kev hloov pauv cov tshuaj tiv thaiv yog ua haujlwm los tsim cov roj rhoifolin (apigenin-7-O-neohesperidoside), uas tom qab ntawd ua tiav los ntawm kev ua kom huv, ntxuav, recrystallization, thiab ziab kom tau qhov nruab nrab. Thaum kawg, hydrolysis generatescrude apigenin, uas dhau mus ua kom huv ntxiv, recrystallization, dej ntxuav, ziab, pulverization, blending, thiab ntim kom tau txais cov khoom siab tshaj -purity apigenin tiav. Tag nrho cov txheej txheem suav nrog cov kuab tshuaj rov qab los ua kom muaj peev txheej rov ua dua tshiab, ua kom cov khoom zoo sib xws thiab kev tsim khoom zoo ib puag ncig.

Apigenin hmoovyog ib tug raug hydrophobic flavonoid nrog tsis tshua muaj neegtsawg dej solubility(kwv yees li 1.35-2.35 ug / mL ntawm 25 degree); Thaum nws zoo li insoluble hauv dej, nws pom zoo solubility hauv dimethyl sulfoxide (DMSO, mus txog 27 mg / mL). Nws solubility hauv cov kuab tshuaj organic xws li kub ethanol thiab methanol yog txwv tab sis nce nrog kub; Nws kuj dissolves nyob rau hauv alkaline tov-xws li dilute poov tshuaj hydroxide- ua ib tug sib sib zog nqus daj xim (nrog los nag tshwm sim raws li acidification), whereas nws qhia siab solubility nyob rau hauv cov tshuaj excipients xws li polyethylene glycol 400 (PEG-400) thiab Transcutol.

Muab hais tias nws cov dej insolubility loj heev txwv lub qhov ncauj bioavailability, cov tswv yim siv feem ntau siv cov tswv yim xws li cov khoom dispersions, nano- formulations, los yog cyclodextrin inclusion complexes los txhim kho nws cov tsos.solubilitythiab kev sib cais tus nqi, yog li ua tau raws li qhov yuav tsum tau muaj rau kev tsim kho thiab kev tshawb fawb pharmacological. Peb lub tuam txhab muab adej- qib soluble ntawm apigenin; thovtiv tauj pebkom paub meej ntxiv.

Hu rau tam sim no

Apigenin thiab Ashwagandhayog cov khoom xyaw ntuj noj qab haus huv uas tau txais kev saib xyuas tseem ceeb hauv xyoo tas los no rau lawv lub luag haujlwm hauv kev daws kev ntxhov siab, txhim kho kev pw tsaug zog, thiab kev txawj ntse; Txawm li cas los xij, lawv txawv ntawm lawv lub hauv paus thiab cov txheej txheem ntawm kev ua.Apigenin hmoovyog ib qho active compound uas feem ntau exerts sedative, anxiolytic, thiab pw tsaug zog - txhawb kev cuam tshuam los ntawm modulating GABAergic system; nws kuj qhia tau tias muaj peev xwm tiv thaiv kab mob neuroprotective, tsom tshwj xeeb rau kev txhawb nqa lub hlwb so thiab kev noj qab haus huv neurological. Piv txwv li,Ashwagandhamuaj ntau yam steroidal lactones (nrog anolides) thiab muaj ntau qhov systemic, muaj ntau yam ntawm cov teebmeem. Nws feem ntau pab lub cev tiv thaiv kev ntxhov siab thiab sib npaug ntawm kev ntxhov siab los ntawm kev tswj hwm qib cortisol, thaum tseem muab cov txiaj ntsig xws li txhawb zog, txhim kho kev tiv thaiv, txhim kho kev pw tsaug zog zoo, thiab ncua kev laus - cuam tshuam los ntawm cov txheej txheem cuam tshuam nrog kev txo qis ntawm oxidative kev nyuaj siab thiab kev tswj hwm ntawm lipid metabolism.

Apigenin thiabfisetinyog ob qho tib si ntuj flavonoids uas qhia tau tias muaj peev xwm rau neuroprotection thiab los tiv thaiv - mob, tab sis lawv txawv ntawm lawv cov qauv molecular thiab cov yam ntxwv ua haujlwm. Tshuaj,apigenin uayog cais raws li flavone, hos fisetin yog flavonol; tom kawg muaj ib pab pawg hydroxyl ntxiv ntawm C-3 txoj hauj lwm ntawm C- nplhaib, ib qho kev sib txawv uas cuam tshuam rau lawv cov kev ua ub no. Thaum ob lub tebchaw muaj ntau yam txiaj ntsig kev noj qab haus huv, fisetin cov qauv nta feem ntau ua rau muaj kev ua haujlwm zoo tshaj plaws antioxidant thiab enzyme-inhibitory, whereasapigenin bulk hmoovtau kawm dav rau nws cov tshuaj tiv thaiv - ua xua thiab immunomodulatory zog.

Apigenin thiabmelatoninyog ob qho tib si tej yam ntuj tso uas feem ntau siv los txhim kho kev pw tsaug zog, tab sis lawv txawv heev nyob rau hauv lawv lub hauv paus chiv keeb, mechanisms ntawm kev txiav txim, thiab functional scope. Melatonin yog endogenous hormone secreted los ntawm lub caj pas pineal; thaum nws ua sai, nws cov teebmeem feem ntau txwv rau kev tswj kev pw tsaug zog thiab kev tswj ntawm circadian rhythms. Hauv qhov sib piv, apigenin yog cov nroj tsuag - muab tau los ntawm flavonoid. Nws tsis muaj qhov ncaj qha hypnotic nws tus kheej tab sis hloov kho cov teebmeem sedative thiab anxiolytic los ntawm kev hloov pauv.GABA(gamma{0}}aminobutyric acid) receptors; los ntawm kev txhawb nqa lub cev thiab lub hlwb so, nws tsis ncaj qha ua rau lub ntuj pib pw tsaug zog.

Qhov tseem ceeb, piv rau cov tshuaj sib xyaw ua ke melatonin- uas tuaj yeem ua rau muaj kev pheej hmoo xws li hormonal dependency, qaug zog thaum sawv ntxov, lossis kev cuam tshuam endocrine-apigenin, raws li cov nroj tsuag extract, feem ntau muaj kev nyab xeeb zoo dua. Nws tsis cuam tshuam nrog lub cev lub cev ntuj tsim melatonin secretion rhythms, ua rau nws muaj kev xaiv zoo dua lipw tsaug zog pabntev -lub sij hawm, noj qab nyob zoo txhua hnub.

apigenin rau pw tsaug zog

Apigenin covpw tsaug zog- txhawb nqa cov txiaj ntsigFeem ntau yog los ntawm nws cov sedative thiab relaxing cuam tshuam rau hauv nruab nrab paj hlwb. Los ntawm kev khi raugamma{0}}aminobutyric acid (GABA)receptors nyob rau hauv lub hlwb, apigenin txo cov kev ua haujlwm neuronal, pab kom so lub cev thiab lub siab thaum inducing tsaug zog. Tsis tas li ntawd, apigenin muaj anxiolytic zog uas alleviate nro thiab nyob tsis tswm, yog li txhawb nqa lub siab lub ntsws kom tsaug zog. Tsis zoo li cov papw tsaug zog pab los yog melatonin, apigenin uatsis ncaj qha cuam tshuam nrog hormonal rhythms; Hloov chaw, nws ua rau pw tsaug zog maj mam- txhawb nqa cov txiaj ntsig los ntawm kev hloov kho cov kab mob neurotransmission, tsis txhob muaj kev vam khom loj lossis tom ntej - hnub tsaug zog. Tsis tas li ntawd, nws cov tshuaj tiv thaiv kab mob antioxidant thiab tiv thaiv - cov khoom ua kom muaj zog pab txo lub cev lub nra ntawm kev mob ntev, ntxiv dag zog rau tag nrho kev pw tsaug zog zoo.

apigenin pab rau cov poj niam

Apigenin hmoovmuaj ntau yam txiaj ntsig zoo rau cov poj niam txoj kev noj qab haus huv, tshwj xeeb tshaj yog hais txog kev tswj hwm ntawm kev ua me nyuam thiabhormonal tshuav nyiaj li cas. Nws cov kev tswj xyuas cov txiaj ntsig ntawm poj niam kev ua me nyuam ua haujlwm pab txhawb kev noj qab haus huv ntawm zes qe menyuam. Nyob rau hauv cov nqe lus ntawm kev tswj hwm hormonal, apigenin khi rau cov tshuaj estrogen receptors thiab exerts estrogen-zoo li cov teebmeem, yog li cuam tshuam rau kev zais ntawm qhov tseem ceeb.tshuaj hormonesxws li estradiol thiab progesterone; qhov no pab tswj lub cev kev coj khaub ncaws thiab muaj txiaj ntsig zoo rau cov xwm txheej cuam tshuam nrog hormonal tsis txaus, xws li polycystic zes qe menyuam syndrome (PCOS). Tsis tas li ntawd, apigenin's antioxidant thiab tiv thaiv - cov khoom siv inflammatory pab txo qis oxidative puas hauv cov nqaij mos ntawm zes qe menyuam thiab qhia cov lus cog tseg hauv inhibiting kev ua haujlwm ntawm zes qe menyuam txawv txav.

apigenin pab rau cov txiv neej

Hais txogtxiv neej noj qab haus huv, apigenin feem ntau ua rau muaj kev tiv thaiv ntawm cov koob tshuaj me me lossis nyob rau hauv cov kab mob pathological, thaum cov koob tshuaj ntau heev yuav ua rau muaj qhov tshwm sim tsis zoo.Apigeninua kom pom ntau lub peev xwm los txhawb kev noj qab haus huv ntawm txiv neej, suav nrog kev ua kom lub cev tsis muaj zog los ntawm cov khoom xws li kev noj zaub mov muaj roj ntau; Nws cov txheej txheem ntawm kev txiav txim koom nrog kev txhawb nqa steroidogenesis hauv cov qe ntshav Leydig hlwb, rov ua kom cov qib ntawm cov tshuaj hormones xws li ntshav ntshav testosterone, thiab txhim kho cov phev tsis zoo. Tsis tas li ntawd,apigenin ua's antioxidant thiab tiv thaiv-cov khoom siv inflammatory pab txo qis oxidative puas nyob rau hauv cov nqaij mos, muab kev tiv thaiv tiv thaiv yeeb tshuaj-induced txiv neej reproductive toxicity.

apigenin rau cov plaub hau

Apigeninmuaj ntau yam txiaj ntsig zoo rau cov plaub hau. Hais txog kev loj hlob ntawm cov plaub hau, nws txhawb cov hauv paus plaub hau thiab nce cov plaub hau tuab los ntawm ntau txoj hauv kev lom neeg, thiab kev tshawb fawb tau lees paub nws cov txiaj ntsig hauv kev txo cov androgenetic alopecia. Nwsmechanisms ntawm kev uakoom nrog ua kom Wnt/ -catenin signaling pathway, inhibiting plaub hau follicle cell apoptosis, thiab downregulating kev qhia ntawm transforming loj hlob yam TGF- 1; Cov kev ua no pab txhawb kev hloov ntawm cov hauv paus plaub hau los ntawm lub sijhawm so (telogen) mus rau theem kev loj hlob (anagen), nce cov hauv paus plaub hau, thiab ua kom ntev.plaub hau kev loj hlobtheem. Nyob rau hauv cov nqe lus ntawm kev ncua greying, cov kev tshawb fawb qhia tias apigenin pab tiv thaiv kev poob ntawm cov plaub hau xim los ntawm kev tswj cov endothelin signaling nyob rau hauv cov plaub hau follicles, yog li khaws cia melanocyte kev ua ub no.

apigenin rau poob phaus

Apigenin exerts nws qhov hnyav- poob cuam tshuam feem ntau los ntawm kev hloov kho lub cev tsis muaj zog thiab ua kom lub cev muaj zog metabolic. Nws cov txheej txheem tseem ceeb suav nrog kev tswj hwm macrophage polarization hauv cov ntaub so ntswg adipose: hauv kev rog rog, macrophages hloov los ntawm kev tiv thaiv -inflammatory M2 phenotype mus rau pro-inflammatory M1 phenotype, yog li exacerbating mob ntev thiab txhawb kev rog. Apigenin txhawb nqa macrophage polarization mus rau M2 phenotype thiab txo qis cov lus teb inflammatory, tom qab inducing lub browning ntawm dawb adipose ntaub so ntswg- ib tug txheej txheem uas ua rau kom lub zog siv. Tsis tas li ntawd, apigenin modulates cov kev qhia ntawm cov noob txuam nrog adipogenesis, pab tiv thaiv cov rog ntau dhau.

apigenin rau kev ntxhov siab

Apigenin ua qauv qhiameej lub peev xwm rau alleviating ntxhov siab vim. Kev tshawb fawb qhia tias apigenin ua rau muaj kev cuam tshuam loj heev los ntawm kev siv tshuab ntau yam: ntawm ib sab, nws cuam tshuam nrogGABAreceptors nyob rau hauv lub hlwb los modulate GABAergic signaling, yog li txhawb kev so ntawm lub paj hlwb thiab kev xav stability; Ntawm qhov tod tes, nws ua los ntawm ntau txoj hauv kev-xws li ua kom lub ERK/CREB/BDNF teeb liab txoj hauv kev, tswj cov qib neurotransmitter (xws li monoaminergic, dopaminergic, thiab serotonergic systems), inhibiting zus tau tej cov pro-inflammatory cytokines, thiab oxidative kev puas tsuaj rau cov neurons. tiv thaiv -txoj kev ntxhov siab.

apigenin rau qhov muag

Covcov txiaj ntsig ntawm apigenin rau qhov muagfeem ntau yog los ntawm nws cov tshuaj tiv thaiv - mob, antioxidant, thiab neuroprotective zog, uas hla ntau thaj tsam ntawm lub qhov muag -los ntawm lub qhov muag mus rau retina. Hais txog lub cornea thiab ocular nto, apigenin nthuav tawm tseem ceeb los tiv thaiv -kev ua ub no. Los ntawm inhibiting qhov tseem ceeb inflammatory signaling txoj kev xws li NF-κB thiab JNK/ERK, nws zoo txo ​​tau cov pro-inflammatory yam, li no alleviating corneal o. Cov yam ntxwv no qhia txog kev muaj peev xwm kho mob xws likab mob qhov muag qhuav; Cov kev tshawb fawb tau pom tias thaum encapsulated hauv nanoparticles, apigenin tuaj yeem thim rov qab cov tsos mob ntawm qhov muag qhuav thiab ua kom lub kua muag tawm.

Apigenin ntxiv

Covsiv apigeninnyob rau hauv cov khoom lag luam kev noj qab haus huv cov chaw ua haujlwm feem ntau ntawm nws cov tshuaj tiv thaiv -inflammatory, antioxidant, thiab neuroprotective zog, ua rau nws yog ib qho khoom muaj npe nrov hauv cov khoom noj khoom haus thiab cov khoom noj khoom haus. Cov tshuaj Apigenin muaj nyob rau hauv ntau hom -xws li ntsiav tshuaj, tshuaj ntsiav, khoom dispersions, thiab nano- formulations, nrogcapsules thiab apigenin ntsiav tshuajua qhov feem ntau. Kev siv ntau yam los ntawm kev mob plawv thiab kev tiv thaiv lub siab mus rau kev ntxhov siab thiab kev pw tsaug zog; tshwj xeeb, cov khoom sib xyaw ua ke tam sim no nquag ua khubntau apigeninnrog rau lwm cov khoom xyaw botanical, xws liashwagandhalos yog magnesium, los daws cov kev xav tau tshwj xeeb xws li txhim kho kev pw tsaug zog zoo lossis txhawb kev tiv thaiv.

Apigenin Functional Foods

Hais txog cov khoom noj tshiab tshiab,gummy ntxivtau tshwm sim los ua ib qho kev nyiam nyob rau xyoo tas los no. Kev tshawb fawb tam sim no suav nrog kev txhim kho ntshav -siab- txo qisapigenin cov gummiesuas ua ke blueberry thiab celery; los ntawm kev sib tw celery- muab losapigenin uanrog rau lwm cov khoom xyaw txiv hmab txiv ntoo thiab zaub, cov khoom no muaj cov txiaj ntsig zoo xws li txhawb kev noj qab haus huv ntshav siab. Kev lag luam tsom xam qhia tias apigenin nkag mus rau hauv kev lag luam hauv cov qauv niaj hnub- xws ligummy, hmoov, thiab dej haus-yog li txhawb nqa nws cov duab raws li kev tshawb fawb muaj txiaj ntsig zoo. Cov ntawv pov thawj cuam tshuam pom tau tias apigenin tuaj yeem ua ke nrog cov khoom xyaw xws linicotinamide mononucleotide (NMN)thiab resveratrol los tsim cov dej haus thiab cov hmoov instant tsim los daws cov kev xav tau xws li kev txhawb zog, kev tswj hwm lub siab, thiab kev tiv thaiv cellular -aging.

apigenin hauv kev tu tawv nqaij

CovKev siv apigenin hauv kev kho tawv nqaijcov khoom lag luam nyob rau ntawm nws cov txiaj ntsig ntau yam-xws li soothing thiab tiv thaiv- kev tsis haum tshuaj, tawv nqaij ci thiab txo qhov chaw tsaus, tiv thaiv- cov khoom qub, thiab tiv thaiv plaub hau tsis zoo- ua rau kev txhim kho ntawm ntau hom khoom. Hauvserums thiab cream, apigenin hmoovfeem ntau ua ke nrog cov khoom xyaw nquag xws li phloretin thiab proanthocyanidins los ua ke inhibit melanin ntau lawm, txo cov tawv nqaij rhiab heev, thiab tiv thaiv kev yees duab. Hauv cov khoom tu plaub hau tsim los tiv thaiv cov plaub hau poob, apigenin tau muab tso rau hauv cov txheej txheem xws li tawv taub hau thiab tshuaj zawv plaub hau los tiv thaiv -, qhov twg nws daws cov plaub hau poob los ntawm kev txhawb cov hauv paus plaub hau thiab ua kom cov plaub hau tuab. Tsis tas li ntawd, ntsej muagdaim npog qhov ncaujleverage apigenin's anti-inflammatory thiab antioxidant zog rau post- hnub kho thiab soothing ntawm daim tawv nqaij rhiab heev.

Hais txog lubkev phiv ntawm apigenin, cov ntaub ntawv tshawb fawb tam sim no feem ntau yog muab los ntawm kev sim tsiaj thiab kev tshawb fawb hauv vitro, thaum cov ntaub ntawv kev nyab xeeb txog tib neeg tseem muaj kev txwv. Cov kev tshawb fawb uas twb muaj lawm qhia tau hais tias apigenin raug suav hais tias muaj kev nyab xeeb ntawm kev noj zaub mov noj ib txwm muaj, thiab tsis muaj qhov cuam tshuam loj heev tau pom nrog ntev - noj zaub thiab txiv hmab txiv ntoo nplua nuj nyob hauvapigenin ua. Txawm li cas los xij, lubkev nyab xeebntawm siab - noj tshuaj ntxiv tseem tsis tau meej; Qee qhov kev tshawb fawb tsiaj qhia tias cov koob tshuaj ntau heev tuaj yeem cuam tshuam nrog kev hloov pauv hauv daim siab enzyme theem, cytotoxic cuam tshuam, thiab muaj peev xwm cuam tshuam rau lub cev xeeb tub.

Peb pom zoo qhov noapigenin hmoovraws li qhov kev xaiv zoo tshaj plaws rau kev tsim cov khoom noj khoom haus, cov khoom noj khoom haus, thiab cov khoom siv tawv nqaij. Ua los ntawm cov txheej txheem rho tawm, peb cov hmoov ua kom muaj kev ruaj ntseg thiab sib xws ntawm cov khoom xyaw nquag; nws98%siab purity thiab tsawg impurity qib lav txhim khu kev qha zoo rau koj cov khoom tiav. Txhawm rau hais txog qhov kev sib tw ntawm kev lag luam ntawm apigenin qhov tsis muaj qhov ncauj bioavailability, peb cov khoom muaj ntau yam thiab sib xws nrog ntau hom kev siv ntau npaum li cas -xws li cov khoom tawg, nano-formulations, gummies, thiab dej haus- ua tau raws li cov kev cai ntawm ntau hom kev siv. Tsis tas li ntawd, peb muab kev txhawb nqa dav dav los pab koj daws teeb meem ntsig txog solubility thiab formulation compatibility thaum lub sij hawm tsim khoom.Lag luam wholesale apigenin hmoov, tiv tauj pebntawminfo@kintaibio.com.

Hu rau tam sim no

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