Diethylamino Hydroxybenzoyl Hexyl Benzoate DHHB hmoov

Noj qab haus huv^®yog aChaw tsim tshuaj paus thiab tsum ntawm DHHB hmoov. Diethylamino Hydroxybenzoyl Hexyl benzoate(feem ntau abbreviated li DHHB) yog ib tug zoo heev, photostable, thiab dav siv tshuaj pleev thaiv hnub tus neeg sawv cev. Tshwj xeeb tsim los nqus UVA hluav taws xob (tshwj xeeb yog UVA-I), nws nta lub siab tshaj plaws nqus wavelength nyob ib ncig ntawm 354 nm, zoo npog tag nrho UVA spectrum. Raws li UVA yog thawj qhov ua rau ntawm daim tawv nqaij photoaging thiab DNA puas,DHHBua hauj lwm ua ib qho zoo heev los tiv thaiv- cov tshuaj pleev thaiv hnub laus.Yuav 99% DHHB hmoov,tiv tauj pebntawminfo@kintaibio.com.

Hu rau tam sim no

Friedel-Crafts Acylation
Covraw khoom, 3-diethylaminophenol thiab phthalic anhydride, raug them rau hauv cov hlab ntsha cov tshuaj tiv thaiv nrog rau cov organic hnyav (xws li toluene) thiab nplawm. Cov tshuaj tiv thaiv sib tov yog rhuab mus rau 110-115℃thiab reacted rau kwv yees li 2 teev los tsim cov nruab nrab, 2-(4-diethylamino-2-hydroxybenzoyl) benzoic acid. Tom qab ua tiav cov tshuaj tiv thaiv, qhov sib tov yog txias rau 0-10℃kom precipitate intermediate raws li ib tug khoom, uas yog ces cais los ntawm pom.

Esterification
1-Chlorohexane (los yog 1-bromohexane) yog ntxiv rau qhov nruab nrab tau txais hauv thawj kauj ruam ua tus neeg sawv cev alkylating, nrog rau cov poov tshuaj carbonate raws li ib qho yooj yim catalyst thiab dimethylformamide (DMF) ua cov kuab tshuaj. Cov sib tov yog rhuab mus rau 100-110℃thiab stirred rau kwv yees li 4 teev, cia cov carboxyl pawg ntawm intermediate react nrog chlorohexane (esterification) thiab qhia ib pab pawg neeg hexyl, yielding.crude DHHB.Tom qab cov tshuaj tiv thaiv, kev rho tawm yog ua los ntawm ethyl acetate thiab dej; cov organic txheej yog sib cais, decolorized nrog activated carbon, thiab thaum kawg concentrated nyob rau hauv txo siab kom tau covDHHB raw khoom.

Kev sib cais thiab kev huv
Cov khoom nyoos yuav tsum tau ua kom huv ntxiv. Cov concentrated residue yog yaj nyob rau hauv methanol (los yog cov kuab tshuaj cawv xws li ethanol los yog 2-butanol) thiab rhuab mus rau 30-50℃kom txog thaum yaj tag. Cov tshuaj yog maj mam txias rau 15-20℃ntawm tus nqi ntawm 2-4℃ib teev kom induce qeeb crystallization ntawm DHHB. Tom qab txias ntxiv rau 0-5 degree, cov crystalline hais tau sau los ntawm kev pom kom tawm los ntawm high-purityDHHB cov khoom kawg.

DHHB (Diethylamino Hydroxybenzoyl Hexyl benzoate)yog ib qho roj-soluble UV absorber nrog heevdej solubility tsawg(kwv yees li 0.00095 g / L); yog li ntawd, nyob rau hauv kev siv tswv yim, nws yuav tsum tau yaj nyob rau hauv cov roj los yog organic solvents. Thaum nwssolubility nyob rau hauv cov organic solventDMSO nce mus txog 55 mg / mL, hauv cov tshuaj pleev ib ce, nws yog qhov zoo tshaj plaws muab tso rau hauv cov roj theem. Solubility sib txawv heev nyob ntawm seb hom roj siv; esters uas muaj benzene nplhaib qauv, xws li phenylethyl benzoate (solubility approx. 596.93 g/L) thiab C12-15 alkyl benzoate (kwv yees . 426.89} g/L), muaj peev xwm solubilizing zoo dua.

Nws yog ib qho tseem ceeb kom nco ntsoov tias thaum lub sij hawm tsim, dissolving cov khoom ntawm cua sov (piv txwv li, ntawm 80 degree) yields ntau dua.ruaj khovthiab zoo tiv thaiv tom qab crystallization piv rau ultrasonic dissolution. Hloov pauv, qis- qhov kub thiab txias cia (piv txwv li, 4 degree) ua rau kom muaj crystallization. Yog li ntawd, ntxiv rau kev xaiv cov roj uas tsim nyog thaum tsim khoom, cov emulsifiers tsim nyog (xws li Span series ntawm sorbitan fatty acid esters) yuav tsum tau siv los txo qis tus nqi ntawm crystallization.

Hais txog kev muaj peev xwm tiv thaiv,DHHByog lub lim dej UVA ua tau zoo nrog lub siab tshaj plaws nqus wavelength ntawm 354 nm; nws muaj kev tiv thaiv ruaj khov thoob plaws tag nrho UVA-I thiab UVA-II spectrums thiab khav theeb zoo heev photostability- tawm tsam degradation nyob rau hauv tshav ntuj los muab kev tiv thaiv ntev -. Nyob rau hauv sib piv, thaumOxybenzoneyog ib qho dav -spectrum UV absorber uas tsom rau UVA thiab UVB, nws raug kev txom nyem los ntawm cov duab tsis zoo thiab degrades yooj yim thaum raug lub teeb.

Kev sib txawv ntawm kev nyab xeeb yog qhov tseem ceeb tshaj,Oxybenzonetau txuas rau endocrine cuam tshuam, bioaccumululation, thiab muaj peev xwm rhiab heev; Cov kev tshawb fawb qhia tias muaj kev pheej hmoo ntawm cov tawv nqaij rhiab heev, ua rau ntau lub teb chaws txwv lossis txwv tsis pub siv tshuaj pleev thaiv hnub. Hloov pauv,DHHB hmoovtau ua pov thawj pom zoo rau kev nyab xeeb profile hauv ntau qhov kev ntsuam xyuas, kuaj qhov tsis zoo rau cov tawv nqaij rhiab hauv vitro kev soj ntsuam thiab raug cais raws li tsis yog -sensitizer los ntawm SCCS (Scientific Committee on Consumer Safety of the EU). Tsis tas li ntawd, raws li ib tug tom ntej - tiam organic UV lim,DHHB ntaumuaj kev sib raug zoo nrog cov dej hiav txwv ecosystems piv rau cov laus - tiam lim zoo li Oxybenzone. Yog li ntawd, ntau cov khoom siv tshuaj pleev thaiv hnub tau xaiv los hloovOxybenzone nrog DHHBkom ua tiav ib qho kev nyab xeeb, ntau tus phooj ywg ib puag ncig, thiab muaj kev tiv thaiv zoo dua.

Diethylamino hydroxybenzoyl hexyl benzoate rau daim tawv nqaij

Lub luag haujlwm tseem ceeb ntawmDHHByog los muab kev tiv thaiv kev tiv thaiv los ntawm kev nqus UVA hluav taws xob zoo, yog li tiv thaiv UV- ntxias cov tawv nqaij puas thiab kev yees duab. Raws li ibroj-solubletshuaj pleev thaiv hnub tshuaj tiv thaiv tus neeg sawv cev, nws pom muaj zog nqus nyob rau hauv lub 320-400 nm UVA ntau yam -nrog lub ncov haum ze ntawm 354 nm- zoo txo ​​qhov tob - cov ntaub so ntswg puas los ntawm UVA rays. Nws qhov tshwj xeeb photostability ua kom nws tsis yooj yim degrade thaum raug lub teeb, muab kev tiv thaiv ntev - ntev thiab txhim khu kev qha. Txij li thaum UVA hluav taws xob nkag mus tob rau hauv daim tawv nqaij thiab ua rau muaj kev puas tsuaj uas ua rau cov cim ntawm kev laus - xws li tawv tawv thiab poob ntawmtawv nqaij tawv -DHHBindirectly pab ncua kev laus ntawm daim tawv nqaij los ntawm thaiv hom ntawm ultraviolet hluav taws xob.

DHHB rau kev tiv thaiv -aging

Raws li ib tugtshuaj pleev thaiv hnubtus neeg sawv cev,DHHBtsis muaj kev tiv thaiv- kev laus hauv kev xav ib txwm muaj; Txawm li cas los xij, los ntawm kev muab kev ruaj khov, dav - spectrum UVA tiv thaiv, nws tiv thaiv kev ncaj ncees ntawm daim tawv nqaij barrier, tiv thaiv cov teeb meem xws li epidermal thinning thiab stratum corneum dysfunction tshwm sim los ntawm cumulative UV puas. Tsis tas li ntawd, los ntawm mitigating UV-induced overexpression ntawm matrix metalloproteinases, nws pab tiv thaiv cov qauv kev ncaj ncees ntawm collagen thiab elastin, yog li tswj cov tawv nqaij firmness thiab elasticity. Nws kuj txo DNA puas thiab apoptosis cuam tshuam nrog UV raug. Yog li ntawd, txawm tiasDHHB hmoovua haujlwm feem ntau los ntawm kev tiv thaiv, nws ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev tiv thaiv - kev laus kev siv zog nyob rau hauv kev kho tawv nqaij zoo los ntawm kev thaiv ntau txoj hauv kev ntawm UV- ua rau muaj kev puas tsuaj.

dHHB tshuaj pleev thaiv hnub

Ua tsaug rau nws cov txiaj ntsig zoo tiv thaiv UVA thiab zoo heev photostability,DHHB (Diethylamino Hydroxybenzoyl Hexyl benzoate)yog dav siv nyob rau hauv ntau yam khoom siv tshuaj pleev thaiv hnub. Rau kev mus ncig txhua hnub, nws feem ntau muab tso rau hauv cov tshuaj pleev thaiv hnub, tshuaj pleev, thiab gels - feem ntau yog siv los ua cov kauj ruam kawg ntawm kev tu tawv nqaij nruab hnub - los muab cov neeg siv khoom hnav, kev tiv thaiv zoo. Rau kev ua si sab nraum zoov thiab raug tshav ntuj ntev, DHHB yog siv rau hauv siab -SPF tshuaj tsuag, sticks, thiab kis las-cov gels taw qhia; nws cov roj-soluble xwm imparts dej thiab hws tsis kam, ua rau nws haum rau xav tau ib puag ncig sab nraum zoov. Ntxiv thiab,DHHByog siv dav hauv cov khoom siv tshuaj pleev ib ce nrog cov txiaj ntsig tiv thaiv hnub ci, xws li lub hauv paus, BB cream, cushion compacts, thiab lipsticks lossis di ncauj balms.

DHHB Kids Sun Spray

DHHB lag luam wholesaleyog dav siv nyob rau hauvtshuaj pleev thaiv hnubcov khoom lag luam rau cov menyuam mos thiab cov menyuam yaus, tshwm sim hauv ntau hom kom haum rau cov xwm txheej sib txawv thiab kev nyiam ntawm daim ntawv thov. Rau kev siv hauv tsev txhua hnub lossis kev tawm mus luv luv, cov tshuaj pleev thaiv hnub thiab cov tshuaj pleev yog cov kev xaiv ntau tshaj plaws; Cov khoom no muaj qhov zoo nkauj moisturizing haum rau cov tawv nqaij qhuav ntawm cov menyuam mos, kis tau yooj yim, thiab muab kev pabcuam rau txhua qhov chaw ntawm lub cev. Cov tshuaj pleev thaiv hnub yog ib qho kev xaiv nrov rau kev ua ub ua no sab nraum zoov lossis mus ncig lub caij ntuj sov, muab qhov zoo ntawm kev yooj yim thiab kev pabcuam dav dav - ua rau lawv zoo tagnrho rau cov menyuam yaus nquag, vim lawv tso cai rau kev thov nrawm thoob plaws lub cev.Tshuaj pleev thaiv hnubsticks zoo dua rau cov chaw mos zoo li lub ntsej muag; tsim los ntawm cov khoom siv los yog tshuaj balm-zoo li hom ntawv, lawv tso cai rau cov ntaub ntawv meej ntawm lub hnub- cov pob khaus xws li lub plhu, qhov ntswg, thiab pob ntseg, thaum txo qhov kev pheej hmoo ntawm cov khoom nkag mus rau hauv lub qhov muag lossis nqus pa.

DHHBsuav hais tias yog tshuaj lom neeg muaj kev nyab xeeb heevtshuaj pleev thaiv hnubtus neeg sawv cev nyob rau hauv ib txwm muaj kev siv; nws tsis muaj kev hloov pauv, genotoxicity, lossis phototoxicity. Muab nws qhov kev nqus ntawm daim tawv nqaij qis heev (kwv yees li 0.15%) thiab kev siv ntau tshaj plaws ntawm 10%, nws khav theeb Margin of Safety (MoS) ntawm 4,705-ntau tshaj qhov kev nyab xeeb-qhia tias muaj kev pheej hmoo tsawg rau tib neeg kev noj qab haus huv. ThaumDHHB hmoovyog qhov muaj kev nyab xeeb raws li cov khoom siv tshuaj pleev thaiv hnub, ua kom cov khoom siv raw purity thiab nruj me ntsis tswj cov DnHexP impurity nyob rau hauv cov kev txwv pom zoo yog qhov tseem ceeb rau kev ruaj ntseg cov khoom.

Peb zoo siab los qhia peb99% DHHB (Diethylamino Hydroxybenzoyl Hexyl Benzoate) hmoov. Raws li cov lim dej UVA ua tau zoo, peb cov khoom lag luam muaj lub zog nqus siab tshaj nyob ze 354 nm, muab kev ruaj khov, puv - spectrum tiv thaiv thoob plaws 320-400 nm ntau yam. Nws boasts zoo heev photostability thiab tsis kam rau photodegradation, kom ntseeg tau ntev - tiv thaiv tshav ntuj. Tshwj xeeb tshaj yog, peb nruj me ntsis tswj cov khoom raw purity- khaws cov ntsiab lus ntawm di-n-hexyl phthalate (DnHexP) impurities qis dua 1 ppm- los lav qhov kev nyab xeeb ntawm cov khoom kawg ntawm qhov chaw. Peb cov DHHB hmoov yog tsim rau ntau hom qauv, nrog rau cov tshuaj pleev thaiv hnub, tshuaj tsuag, sticks, thiab hnub ci{14}}cov tshuaj pleev ib ce tiv thaiv; nws muaj cov roj solubility zoo heev thiab sib xws nrog ntau yam UVB lim.Tiv tauj pebntawminfo@kintaibio.com.

Hu rau tam sim no

Cim npe nrov: Diethyl benzoyl hexyl benzoate dhhb hmoov, Tuam Tshoj diethylamino hydroxybenzoyl hexyl benzoate dhhb hmoov manufacturers, lwm tus neeg, Hoobkas