Cov kev phiv ntawm Lappaconitine Hydrobromide yog dab tsi?

Lappaconitine (tseem hu ua spiny aconitine, labaconitine, LH) yog ib qho alkaloid rho tawm los ntawm cov hauv paus hniav ntawm Aconitum sinomontana -num Nakai, ib tsob nroj ntawm tsev neeg Ranunculaceae. Nws yog thawj zaug uas tsis yog - cov tshuaj tua kab mob uas tsim tawm hauv Suav teb thiab siv los kho mob hnyav lossis mob hnyav. Cov khoom no muaj cov nyhuv analgesic muaj zog, piv rau pethidine hauv cov nyhuv analgesic, nrog rau qhov pib qeeb me ntsis thiab lub sijhawm ua haujlwm ntev dua. Nws cov nyhuv analgesic yog xya npaug ntawm cov tshuaj antipyretic analgesic aminopyrine. Toxicology: Cov khoom no tsis muaj cov nyhuv teratogenic hauv kev tshawb fawb tsiaj. Lappaconitine hydrobromide muaj cov tshuaj tiv thaiv tseem ceeb - mob, tiv thaiv - edema, antipyretic, thiab tshuaj loog hauv zos. Clinically, lapaconitine feem ntau yog siv los kho mob qog noj ntshav thiab tom qab phais mob analgesia.

Kintai yog ib lub tuam txhab kev cog qoob loo. Peb muaj - zoo lappaconitine hydrobromide, thov koj xav tias dawb rautiv tauj pebntawmhealth@kintaibio.com.

Lub toxicity ntawm lappaconitine hydrobromide tshwm sim los ntawm nws cov txheej txheem analgesic. Nws yog sodium channel inactivation stabilizer, feem ntau ua rau voltage-gated sodium channels hauv paj hlwb thiab cov leeg nqaij. Nws lub luag haujlwm tseem ceeb yog "thaiv" cov channel no, tiv thaiv lawv los ntawm kev rov qab mus rau lawv lub xeev tsis muaj zog tom qab kev ua haujlwm ib txwm ua, ua rau muaj qhov txo qis ntawm cov xov tooj ntawm cov sodium. Thaum qhov no ua tau zoo thaiv cov teeb liab kis tau tus mob los ntawm qhov mob-sensing qab haus huv, ua kom muaj zog analgesic nyhuv, qhov kev nthuav dav sodium channel inhibition kuj yog ob- ntaj ntug.

Hauv kev siv tshuaj ntau dhau lossis hauv cov tib neeg uas muaj qhov tsis hnov ​​​​tsw, qhov kev cuam tshuam no tuaj yeem dhau qhov kev txwv kev nyab xeeb thiab cuam tshuam rau lub neej tseem ceeb -txoj kev txhawb nqa. Nws qhov cuam tshuam loj tshaj plaws yog nyob rau ntawm lub plawv: nws tuaj yeem cuam tshuam loj rau cov hluav taws xob ib txwm ua ntawm cardiomyocytes, ua rau tuag taus arrhythmias xws li ventricular fibrillation thiab txawm tias lub plawv nres. Nws tseem tuaj yeem cuam tshuam qhov chaw ua pa thiab cov leeg ua pa, ua rau ua pa tsis ua haujlwm. Tsis tas li ntawd, cov tsos mob thaum ntxov yuav muaj xws li loog ntawm daim di ncauj, caj dab, thiab kiv taub hau. Yog li ntawd, thaum nws yog ib qho tseem ceeb hauv kev kho mob uas tsis yog - quav tshuaj, nws lub qhov rais kho mob yog nqaim, yuav tsum tau noj nruj me ntsis thiab siv raws li tus kws kho mob saib xyuas kom muaj kev nyab xeeb.

Cov txheej txheem tseem ceeb ntawm kev ua ntawm lappaconitine hydrobromide nyob rau hauv nws lub peev xwm los tshwj xeeb lub hom phiaj voltage -gated sodium channels ntawm paj hlwb thiab cov leeg cell membranes. Tsis yog tiv thaiv cov channel 'thawj qhib, nws ua raws li "molecular wedge," ruaj khov thiab ruaj khov ntawm cov channel 'inactivated state, ho ncua los yog tiv thaiv lawv rov qab los ntawm inactivated lub xeev mus rau ib tug so, standby lub xeev. Cov txheej txheem no ua rau txo qis hauv cov xov tooj ntawm cov kev ua haujlwm sodium channel muaj nyob rau ntawm cov cell membrane.

Qhov no sib sau ua ke nws cov tshuaj tua kab mob thiab tshuaj lom: Hais txog kev ua xua, sodium channels hauv cov hlab ntsha (tshwj xeeb yog txoj hauv kev mob) ua "jammed," zoo inhibiting tiam thiab kev ua ntawm kev ua tau zoo thiab tiv thaiv qhov mob tshwm sim los ntawm kev ncav cuag lub hlwb, uas ua rau muaj zog thiab tsis yog -kev quav tshuaj quav cawv. Txawm li cas los, qhov no mechanism kuj underlies nws toxicity. Hauv kev siv tshuaj ntau dhau, kev cuam tshuam dav dav ntawm sodium channel tuaj yeem cuam tshuam cov txheej txheem tseem ceeb. Kev cuam tshuam nrog cardiomyocytes tuaj yeem ua rau mob arrhythmias lossis txawm tias lub plawv nres, thaum inhibition ntawm qhov chaw ua pa thiab cov leeg ua pa tuaj yeem ua rau ua pa tsis ua haujlwm. Yog li ntawd, nws cov nyhuv analgesic zoo heev thiab muaj peev xwm ua neej nyob -kev hem thawj yog ob sab ntawm tib lub tshuab molecular ua yeeb yam ntawm ntau qib thiab qhov chaw.

1. Cov hlab ntsha thiab lub siab tsis zoo

Qhov no yog qhov tshwm sim feem ntau. Vim tias cov tshuaj inhibitory cuam tshuam ntawm sodium channels hauv paj hlwb, cov neeg mob feem ntau ntsib cov tsos mob xws li kiv taub hau, tsaug zog, thiab qaug zog. Tsis tas li ntawd, paresthesias tuaj yeem tshwm sim, tshwm sim raws li loog loog, tingling, los yog nkag mus rau hauv daim di ncauj, ceg, lossis daim tawv nqaij ntawm tag nrho lub cev. Cov tsos mob no feem ntau tshwm sim ntawm cov tshuaj kho mob thiab feem ntau mob me, tab sis ceev faj yog qhia raws li lawv tej zaum yuav yog ib tug precursor rau ntau lub hauv paus paj hlwb suppression.

2. Cov teebmeem hauv plawv

Qhov no yog qhov mob hnyav tshaj plaws thiab feem ntau cuam tshuam txog kev mob tshwm sim. Lappaconitine hydrobromide cuam tshuam nrog sodium channels hauv myocardial cells, uas ua rau muaj ntau yam mob plawv arrhythmias. Cov neeg mob yuav hnov ​​​​mob, plawv dhia, bradycardia, lossis tachycardia, thiab electrocardiogram (ECG) abnormalities tuaj yeem tshwm sim. Cov mob hnyav tuaj yeem ua rau tuag taus ventricular tachycardia lossis ventricular fibrillation, ua rau lub plawv nres. Yog li ntawd, cov neeg mob uas muaj kab mob hauv lub plawv yuav tsum tau ceev faj heev thiab ua tib zoo saib xyuas.

3. Digestive System thiab lwm yam kev mob tshwm sim

Qee tus neeg mob yuav muaj kev cuam tshuam ntawm plab hnyuv xws li xeev siab, ntuav, tsis qab los noj mov, thiab mob plab plab. Tsis tas li ntawd, qee cov neeg mob yuav muaj kev tsis haum tshuaj xws li pob khaus thiab khaus khaus. Txawm hais tias cov tshuaj tiv thaiv no feem ntau tsis tshua muaj mob hnyav dua li cov kev mob tshwm sim hauv paj hlwb thiab mob plawv, yog tias lawv pheej los yog hnyav zuj zus, kev kho tam sim thiab kev kho cov tshuaj kho mob raug lees paub.

• High -zoo:Los ntawm kev tsim qauv tsim, peb 96% Lappaconite Hydrobromide ua tiav kev tswj hwm nws peb lub ntsiab alkaloids. Qhov no ua kom muaj qhov tshwj xeeb batch- rau-batch sib xws, xa cov txiaj ntsig zoo thiab muaj kev nyab xeeb zoo dua.
• International Certification:Peb muaj cov ntawv pov thawj thoob ntiaj teb xws li ISO, HACCP, HALAL, KOSHER, Technical Invention Patent Certificate, thiab lwm yam, thiab peb tuaj yeem muab cov khoom zoo rau koj raws li cov kev cai thoob ntiaj teb.
• Customizable:Peb tuaj yeem ua tau raws li tus kheej xav tau ntawm cov neeg siv khoom, muab kev pabcuam OEM & ODM rau koj, thiab kho cov kev daws teeb meem tshwj xeeb rau koj.