Naringinyog ib qho ntawm ntau tshaj plaws flavonoids pom nyob rau hauv citrus txiv hmab txiv ntoo thiab tau garnered nce kev mloog nyob rau hauv xyoo tas los no rau nws lub luag hauj lwm nyob rau hauv cardiometabolic noj qab haus huv. Raws li lub ntuj antioxidant, naringin tau pom tias muaj ntau yam khoom siv tshuaj, suav nrog kev tiv thaiv - cov teebmeem inflammatory, lipid- tswj kev muaj peev xwm, thiab muaj peev xwm txhim kho vascular endothelial muaj nuj nqi. Cov kev tshawb fawb soj ntsuam pom tau hais tias kev noj cov tshuaj naringin nruab nrab tuaj yeem cuam tshuam qhov txo qis ntawm tag nrho cov roj (cholesterol) thiab qis -cov qib lipoprotein ntom ntom (LDL), nrog rau pab txo qis cov hlab ntsha thiab cov kab mob inflammatory. Txawm li cas los xij, vim nws qhov tsis muaj bioavailability tsawg thiab muaj peev xwm ntawm kev cuam tshuam nrog qee cov tshuaj, cov neeg siv khoom yuav tsum ua tib zoo xav txog yuav ua li cas ntxiv nrog naringin kom muaj kev nyab xeeb thiab muaj txiaj ntsig zoo.
Naringin yog dab tsi?
Naringinyog cov nroj tsuag ntuj tsim los ntawm tsev neeg flavonoid; Nws yog feem ntau pom nyob rau hauv lub tev thiab pulp ntawm citrus txiv hmab txiv ntoo xws li grapefruits thiab pomelos, thiab yog lub luag hauj lwm rau me ntsis iab txuam nrog lawv. Ua raws li tus neeg sawv cev tiv thaiv ntuj rau cov txiv hmab txiv ntoo, naringin tau pom nyob rau hauv cov kev tshawb fawb los muab cov tshuaj tua kab mob antioxidant thiab tiv thaiv - inflammatory zog, nrog rau lub peev xwm los tswj cov ntshav lipids - muaj peev xwm muaj txiaj ntsig zoo rau cov hlab plawv. Yog li ntawd, nws feem ntau tsim los rau hauv cov khoom noj khoom haus thiab nyiam los ntawm kev noj qab haus huv- cov neeg paub qab hau. Txawm li cas los xij, ob lub ntsiab lus yuav tsum tau sau tseg: thawj zaug, naringin tsis yooj yim nqus ncaj qha los ntawm lub cev thiab yuav tsum tau hloov pauv hauv cov hnyuv thiab daim siab ua haujlwm; Qhov thib ob, nws tuaj yeem cuam tshuam cov metabolism ntawm qee yam tshuaj, xws li statins thiab tshuaj tiv thaiv kab mob, yog li nws raug nquahu kom sab laj nrog kws kho mob ua ntej noj nws yog tias koj tab tom noj tshuaj.
Naringin ua haujlwm li cas?
Thaum nkag mus rau tib neeg lub cev, naringin tsis ua raws li nws daim ntawv qub; Hloov chaw, nws tau hloov pauv zuj zus hauv cov hnyuv thiab lub siab mus rau hauv cov metabolites nquag-xws li naringenin- uas tau siv ntau dua los ntawm cov hlwb. Cov metabolites nkag mus rau hauv cov hlwb thiab koom nrog kev tswj hwm ntawm ntau txoj hauv kev taw qhia. Ntawm ib sab, lawv qhib lub cev endogenous antioxidant tiv thaiv kab ke- txhawb nqa qib ntawm superoxide dismutase thiab glutathione, piv txwv li- yog li pab txhawm rau tshem tawm cov dawb radicals ntau dhau thiab txo oxidative puas tsuaj.
Ntawm qhov tod tes, lawv inhibit qhov tseem ceeb inflammatory kev taw qhia txoj hauv kev, xws li MAPK thiab NF-κB txoj hauv kev, yog li txo qhov kev tso tawm ntawm pro- mob xws li interleukin-6 thiab qog necrosis factor-alpha. Nyob rau theem vascular thiab metabolic, naringin metabolites txhim kho kev ua haujlwm ntawm endothelial nitric oxide synthase thiab nce nitric oxide ntau lawm, pab cov hlab ntsha tswj cov vasodilatory ib txwm ua haujlwm; Tib lub sijhawm, lawv tswj cov kev qhia ntawm low-density lipoprotein (LDL) receptors hauv daim siab, pab txo qis tag nrho cov roj cholesterol thiab LDL qib hauv cov ntshav.
Cov txiaj ntsig Naringin Supplements yog dab tsi?
Cov txiaj ntsig tseem ceeb ntawm naringin supplementation center ntawm kev tiv thaiv kab mob plawv, kev tswj cov kab mob metabolic, thiab tiv thaiv -inflammatory thiab antioxidant teebmeem. Hais txog kev noj qab haus huv ntawm cov hlab plawv, cov kev tshawb fawb soj ntsuam qhia tau hais tias kev noj tshuaj txhua hnub nrog 400-450 mg ntawm naringin pab txo qis cov roj cholesterol tag nrho thiab qib qis -density lipoprotein (LDL) thaum txhim kho superoxide dismutase kev ua hauv erythrocytes.
Hauv cov tib neeg uas muaj ntshav qab zib mellitus, 12-lub lim tiam kev tswj hwm ntawm cov tshuaj citrus flavonoid uas muaj naringin tau pom tias txo qis cov ntshav qabzib, cov tshuaj insulin tsis kam, thiab glycated hemoglobin (HbA1c), nrog rau txo cov cim ua mob xws li interleukin-6 thiab qog nqaij hlav necrosis (TNF6}). Nyob rau hauv cov nqe lus ntawm vascular muaj nuj nqi, naringin txhim kho cov kev ua ntawm endothelial nitric oxide synthase thiab nce nitric oxide bioavailability, yog li txhim kho endothelium-nyob vasodilation.
Puas yog nws zoo los noj Naringin Supplements daliy?
Sebnaringin tshuaj ntxivtuaj yeem noj txhua hnub nyob ntawm qhov ntau npaum li cas thiab cov xwm txheej ntawm tus kheej. Cov kev tshawb fawb tam sim no qhia tias kev noj txhua hnub ntawm 100 mus rau 500 mg ntawm naringin feem ntau suav hais tias muaj kev nyab xeeb thiab zoo - zam los ntawm tib neeg. Kev sim tshuaj Phaj I uas suav nrog cov neeg noj qab haus huv tshwj xeeb tau soj ntsuam kev nyab xeeb ntawm ntau cov tshuaj naringin ntsiav tshuaj, feem ntau yog saib xyuas cov xwm txheej tsis zoo thiab kev hloov pauv hauv kev sim ntsuas ntsuas. Hauv kev tshawb fawb tsiaj, Beagle dev noj naringin qhov ncauj rau 3 mus rau 6 lub hlis tsis pom muaj tshuaj lom-txog cov xwm txheej; qhov tsis muaj-saib- tsis zoo- theem cuam tshuam (NOAEL) yog tsawg kawg yog 500 mg / kg ntawm lub cev hnyav ib hnub.
Txawm li cas los xij, ob lub ntsiab lus yuav tsum tau sau tseg txog kev siv txhua hnub: ua ntej, naringin tuaj yeem cuam tshuam cov hnyuv organic anion - thauj polypeptides (OATPs) thiab cov tshuaj -metabolizing enzyme CYP3A4, uas muaj peev xwm hloov pauv bioavailability ntawm cov tshuaj xws li felodipine, alicurentine ntawm contraindications, thaum noj fex. Qhov thib ob, qhov kev pom zoo ntau npaum li cas rau cov khoom lag luam muaj nyob hauv cov tshuaj feem ntau yog ib qho tshuaj ntsiav noj ib zaug lossis ob zaug ib hnub, thiab noj nrog zaub mov yuav ua rau lub cev muaj zog.
Qhov twg yuav qhov zoo tshaj plaws Naringin hmoov?
Peb xav kom peb cov hwm zoonaringinhmoov rau cov tuam ntxhab ntawm naringin- raws li kev noj qab haus huv ntxiv. Refined los ntawm citrus txiv hmab txiv ntoo-xws li txiv kab ntxwv qaub- siv cov txheej txheem extraction siab heev, peb cov khoom nta zoo ib yam purity, uniform xim, thiab zoo heev solubility dej, ua rau nws zoo tagnrho rau siv nyob rau hauv ntau npaum li cas cov ntaub ntawv, xws li tshuaj ntsiav, ntsiav tshuaj, hmoov, thiab dej haus. Peb nruj me ntsis ua raws li GMP cov qauv; Txhua pawg tau dhau los kuaj HPLC los xyuas kom meej cov ntsiab lus naringin thiab ua raws li cov qauv thoob ntiaj teb hais txog cov hlau hnyav thiab cov kev txwv microbiological. Tsis tas li ntawd, peb muab cov kev qhia tshwj xeeb tshwj xeeb- txhawb nqa kev tsim ntau npaum li ntawm 100 mg txog 500 mg- thiab koom tes nrog cov neeg siv khoom ntawm cov qauv kev ua kom zoo dua qub thiab kev tshawb fawb ruaj khov. Hu rau peb ntawminfo@kintaibio.com.
FAQ
Q: Qhov txawv ntawm Naringin thiab Naringenin yog dab tsi?
A: 1.Naringin yog glycoside daim ntawv pom nyob rau hauv citrus peels, muaj xws li naringenin txuas mus rau ib tug qab zib molecule. Naringenin yog daim ntawv aglycone uas tseem tshuav tom qab cov piam thaj raug tshem tawm thaum lub plab zom mov. Naringin muaj qhov ncauj bioavailability tsawg thiab yuav tsum tau hloov mus rau hauv naringenin los ntawm cov kab mob plab thiab lub siab enzymes ua ntej nws tuaj yeem ua rau feem ntau ntawm nws cov teebmeem lom. Nyob rau hauv luv luv, naringin yog lub precursor thiab naringenin yog cov nquag metabolite.
Q: Cov zaub mov twg muaj ntau tshaj ntawm Naringin?
A: Grapefruit yog cov nplua nuj nyob hauv ntuj, tshwj xeeb tshaj yog cov tev thiab cov pith dawb, qhov twg naringin concentrations tuaj yeem ncav cuag ntau pua milligrams ib 100 grams. Lwm cov txiv hmab txiv ntoo citrus xws li pomelo, txiv kab ntxwv qaub, thiab qee hom txiv qaub thiab txiv qaub kuj muaj qhov tseem ceeb. Vim hais tias naringin yog lub luag hauj lwm rau iab saj, kua txiv hmab txiv ntoo uas muaj tev cov khoom xyaw yuav muaj ntau dua li cov kua txiv hmab txiv ntoo tshiab uas tsis muaj pith.
Q: Puas yog Naringin cuam tshuam nrog kev sib cuam tshuam ntawm cov kua txiv hmab txiv ntoo?
A: Yog. Naringin yog ib qho ntawm cov ntsiab lus tseem ceeb tom qab lub qhov dej -paub txiv kab ntxwv kua txiv hmab txiv ntoo sib cuam tshuam. Nws inhibits plab hnyuv CYP3A4 thiab cov organic anion thauj polypeptides, uas tuaj yeem ua rau kom nqus tau thiab cov ntshav ntawm qee yam tshuaj xws li felodipine, aliskiren, thiab fexofenadine. Vim hais tias cov tshuaj naringin tuaj yeem tsim cov txiaj ntsig zoo ib yam, ib tus neeg noj tshuaj yuav tsum sab laj nrog kws kho mob ua ntej muab lawv nrog naringin.
Q: Puas yog Naringin muaj kev nyab xeeb rau kev siv sijhawm ntev -?
A: Cov pov thawj tam sim no qhia tias kev noj tshuaj naringin txhua hnub ntawm koob tshuaj ntawm 100 thiab 500 milligrams tau txais txiaj ntsig zoo rau cov neeg laus noj qab haus huv. Kev sim tshuaj Phase I thiab rau rau -hloov kev tshawb fawb dev pom tsis muaj kev cuam tshuam loj heev ntawm cov koob tshuaj me me. Txawm li cas los xij, ntev - cov ntaub ntawv kev nyab xeeb tib neeg ntev tshaj li ob peb lub hlis tseem muaj kev txwv, thiab kev cuam tshuam cov tshuaj yeeb tshuaj tseem muaj kev txhawj xeeb. Kev siv sijhawm ntev - yog li ntawd yuav tsum tau tham nrog kws kho mob, tshwj xeeb tshaj yog rau cov neeg muaj lub siab lossis lub raum.