Podophyllin rau Warts

Nyob rau hauv keeb kwm ntawm kev kho mob dermatology, tshwj xeeb tshaj yog nyob rau hauv toj roob hauv pes ntawm cov tshuaj rau kev sib deev kis kab mob,Podophyllinoccupies ib tug tshwj xeeb thiab tseem ceeb txoj hauj lwm. Nws tsis yog ib qho tshuaj sib xyaw ua ke, tab sis sib xyaw ntawm cov khoom siv ntuj tsim tawm los ntawm cov nroj tsuag, feem ntau los ntawm rhizome ntawm Podophyllum. Qhov no zoo nkaus li zoo tib yam, daj lossis xim av- daj hmoov muaj cov khoom siv tshuaj muaj zog.Peb yogchaw tsim tshuaj paus thiab tsumntawmPodophyllum Resin Podophyllin hmoov. Tiv tauj peb ntawminfo@kintaibio.com.

RauB2B cov neeg siv khoom,Podophyllin hmoovyuav tsum tau ua ntej kom meej meej nws ob lub luag hauj lwm raws li ob qho tib si ib tug active tshuaj ingredient (API) thiab ib tug precursor rau tshuaj formulation. Clinically, nws tau ua tiav rau hauv tinctures los yog cov kev daws teeb meem ntawm cov ntsiab lus tshwj xeeb thiab tau raug suav tias yog thawj zaug - cov tshuaj pleev xim rau kev kho mob ntawm qhov chaw mos los ntawm cov kws kho mob dermatologist thoob ntiaj teb tau ntau xyoo lawm. Nws lub hauv pausmechanism ntawm kev uadag nyob rau hauv kev cuam tshuam nrog cell division: nws muaj cov khoom xyaw nquag xws li podophyllotoxin, uas tuaj yeem tsom thiab khi rau microtubule proteins hauv cov hlwb, yog li thaiv cov metaphase ntawm cell mitosis. Yooj yim muab tso, qhov tseem ceeb ntawm qhov chaw mos kab mob yog qhov txawv txav thiab loj hlob sai ntawm cov cell epidermal tom qab kis tus kab mob HPV, thiabPodophyllinua zoo li ib khub ntawm txiab, tiv thaiv kev faib tawm ntawm cov kab mob no, ua rau lawv maj mam tuag thiab slough tawm.

Cov lus teb yog yog. Cov ntaub ntawv kho mob qhia tau tias nrog kev siv kom raugPodophyllinkev npaj, qhov tshem tawm ntawm qhov chaw mos cov pob qij txha tuaj yeem ncav cuag qib siab. Piv txwv li, ib txoj kev tshawb fawb qhia tau hais tias thaum lub sij hawm kho mob 6 lub lis piam, cov neeg mob siv cov ntsiab lus tshwj xeebPodophyllin hmoovua tiav qhov kev tshem tawm ntawm cov pob txha ntawm 83.3% lossis siab dua. Lwm txoj kev tshawb fawb ntawm qhov chaw mos thiab lub ncauj tsev menyuam qhov ncauj qhov ntswg kuj qhia tau hais tias cov tshuaj pleev ib ce ntawm 25% Podophyllin cov tshuaj ua rau muaj qhov txhab regression nyob rau hauv tag nrho 85 tus neeg mob, tsuas yog ob peb rov tshwm sim tom qab ib hlis. Cov kev rov tshwm sim no tau daws nrog kev kho mob tom ntej, ua kom pom nws qhov pib sai thiab muaj txiaj ntsig zoo.

Txawm li cas los xij, leej twg xyaumqhov chaw mos wartKev kho mob paub tias qhov kev sib tw tseem ceeb tsis yog hauv kev tshem tawm cov warts, tab sis hauv kev tiv thaiv kev rov tshwm sim. Hais lus nruj me ntsis, Podophyllin yog ib qho tshuaj tua kab mob zoo heev, tsis yog kev kho kom tiav. Nws feem ntau tsom rau cov pom warts uas twb muaj lawm, corroding los yog ua rau lawv necrose thiab slough tawm los ntawm cytotoxic kev txiav txim, tab sis nws tsis muaj peev xwm tshem tawm cov kab mob HPV latent hauv lub cev.

Qhov no tau raug lees paub nyob rau hauv kev tshawb fawb sib piv: thaum lub sijhawm ib xyoo tom qab- nce, tus nqi rov qab yog 0% hauv cov pab pawg kho mob diphenylcyclopropenone, thaum tus nqi rov tshwm sim hauv pawg podophyllin yog siab li 77.8%. Cov ntaub ntawv no tsis txhais hais tias podophyllin tsis muaj txiaj ntsig; theej, nws txhais tau meej nws qhov chaw kho mob: nws yog qhov nrawm, ua tau zoo, thiab tus nqi -kev kho lub cev / tshuaj lom neeg puas tsuaj. Rau B2B, podophyllin yog ib qho cuab yeej siv tau zoo rau kev hais txog cov neeg mob qhov kev xav tau ceev ceev, tab sis nws feem ntau yuav tsum tau ua ke nrog lwm cov kev kho mob immunomodulatory los yog ua raws li- cov kev pab cuam, uas yog qhov tseeb ntawm kev lag luam nkag mus rau cov nqi ntxiv ntawm cov kev pab kho mob.

Kev tsom xam tob ntawm pathophysiologicalMechanism ntawm kev ua ntawm Podophyllinpab peb piav qhia txog nws txoj kev kho mob rau cov neeg siv kawg (cov neeg mob lossis kws kho mob). Lub ntsiab active ingredient ntawmPodophyllin yog podophyllotoxin, tus neeg sawv cev antimitotic hu ua spindle toxin. Thaum lub sij hawm ib txwm cell faib, tubulin polymerizes tsim spindle fibers, lub luag hauj lwm rau precisely coj lub replicated chromosomes rau hauv ob tug ntxhais hlwb.

Cov tshuaj PodophyllotoxinQhov kev txiav txim yog muaj zog heev: nws reversibly khi rau tubulin, tsim ib tug complex uas tiv thaiv ntxiv microtubule polymerization. Peb tuaj yeem xav txog cov txheej txheem no raws li kev sib tw marathon (mitosis) uas lub xov tooj ntawm tes teeb tsa ib qho kev cuam tshuam tsis tau. Lub cell yog li raug ntes nyob rau hauv "nruab nrab- rau- lig" theem ntawm kev faib, tsis tuaj yeem ua tiav cytokinesis, thiab thaum kawg raug apoptosis lossis necrosis. Vim hais tias cov hlwb ntawm condyloma acuminata proliferate sai heev, lawv nyob deb ntau rhiab heev rau Podophyllin tshaj li ib txwm, quiescent epidermal hlwb.

Tsis tas li ntawd, cov kev tshawb fawb tau qhia tiasPodophyllinmuaj qee yam tshuaj tiv thaiv kab mob, ncaj qha inhibiting qee qhov haujlwm ntawm cov kab mob hauv cov hlwb. Txawm li cas los xij, lub zog bioactivity no yog ob- ntaj ntug. Nws tsis tsuas yog tua cov kab mob, tab sis yog tias nws los rau hauv kev sib cuag nrog ib puag ncig ntawm daim tawv nqaij los yog mucous daim nyias nyias, nws tuaj yeem ua rau liab, yaig, thiab txawm tias mob hnyav. Yog li ntawd, kev xyaum kho mob qhia meej txog daim ntawv thov thiab kev tiv thaiv ntawm cov ntaub so ntswg ib puag ncig.

RauB2Bcov neeg yuav khoom, nkag siab txog cov txheej txheem no txhais tau hais tias kev saib xyuas cov cuab yeej nrog (xws li daim ntawv thov nyias) thiab cov lus ceeb toom tiv thaiv hauv cov lus qhia thaum yuav khoom. Qhov no tsis yog qhov yuav tsum tau ua raws li kev kho mob nkaus xwb tab sis kuj yog ib qho tseem ceeb ntawm kev txo tus kws kho mob - cov neeg mob tsis sib haum xeeb. Nyob rau tib lub sijhawm, nws tseem ceeb heev kom paub qhov txawv ntawmPodophyllin thiab Podofilox: tom kawg yog ib qho kev ua kom huv si, uas, txawm tias tsis tshua muaj kev khaus thiab FDA pom zoo, tseem muaj qhov zoo dua qub hauv kev puas tsuaj rau lub cev ntawm qee cov pob txha tawv, ua cov khoom sib xyaw.

Tsis zoo li qis -cov kua nplaum uas cov neeg mob siv tau hauv tsev, ib txwm muaj 25%Podophyllintincture, vim nws muaj zog corrosiveness thiab muaj kev pheej hmoo ntawm kev nqus dej, tau pom zoo los ntawm cov txheej txheem kev kho mob thoob ntiaj teb thiab hauv tsev tsuas yog siv los ntawm cov kws kho mob nkaus xwb thiab raug txwv tsis pub muab rau cov neeg mob hauv tsev kho mob.

Ua ntej, thaj chaw muaj kev cuam tshuam yuav tsum tau muab ntxuav kom huv nrog cawv lossis dej thiab qhuav ua ntej kev kho mob kom tsis txhob muaj dej los ntawm diluting cov tshuaj thiab tiv thaiv lub cev stratum corneum. Nyob rau tib lub sijhawm, nws yuav tsum tau ua kom ntseeg tau tias lub pob zeb pob zeb zoo li qub, tsis muaj los ntshav lossis puas tsuaj. Tom ntej no, tus kws kho mob yuav tsum siv lub applicator los yog nyias applicator muab nrog lub hau lub raj mis los kos cov tshuaj, thiab maj mam muab tshem tawm cov tshuaj ntau dhau los ntawm scraping raws ntug ntawm lub raj mis qhib, kom lub applicator semi{2}} qhuav.

Txhawm rau tiv thaiv ib puag ncig ilv mucous daim nyias nyias los yog daim tawv nqaij, nws raug nquahu kom siv roj av jelly lossis zinc oxide ointment ua qhov thaiv ua ntej. Lub sijhawm sib cuag yog qhov tseem ceeb heev. Rau qhov kev kho mob thawj zaug, vim yog qhov sib txawv ntawm ib tus neeg hauv rhiab heev, nws raug nquahu kom tso cov tshuaj rau 30-40 feeb nkaus xwb thiaj li tso cai rau kev soj ntsuam ntawm cov tshuaj tiv thaiv hnyav. Feem ntau, nyob ntawm qhov loj thiab tuab ntawm warts, cov tshuaj yuav tsum nyob twj ywm ntawm daim tawv nqaij li 1 mus rau 4 teev.

Hais txogkoob tshuajKev txhawj xeeb rau cov tsev kho mob hauv kev yuav khoom thiab kev siv tshuaj kho mob, peb yuav tsum paub qhov txawv ntawm ob lub ntsiab lus: qhov concentration specifications ntawm cov tshuaj tiav thiab qhov ntim txwv rau ib daim ntawv thov. Cov kev lag luam uas muaj ntau tshaj plaws yog formulation25% Podophyllinhauv Benzoin Tincture. Qhov no yog hais txog qhov concentration ntawm cov khoom xyaw nquag, uas feem ntau suav hais tias yog tus qauv siv tau zoo rau qhov chaw mos warts.

Txawm li cas los xij, kev txiav- kev tshawb fawb tshuaj kho mob yog tshawb nrhiav qhov zoo tshaj plaws concentration gradients. Interestingly, ib tug classic txoj kev tshawb fawb luam tawm nyob rau hauv 1998 piv ib tug tsawg-concentration 0.5% / 0.25% cawv tov nrog ib txwm 25% siab-concentration tincture. Cov txiaj ntsig tau pom tias 6-lub lim tiam tshem tawm tus nqi (81.8%-100%) nyob rau hauv qis- pawg concentration tsis qis dua li hauv pawg siab siab (83.3%), thiab qhov tshwm sim ntawm daim tawv nqaij khaus nyob rau hauv pawg tsawg-concentration yuav qis dua. Qhov no qhia tau hais tias kev hloov kho concentration ntawm tus kheej rau qhov chaw sib txawv (piv txwv li, mucous membranes vs. keratotic daim tawv nqaij) lossis cov neeg mob uas muaj qhov sib txawv yog qhov sib txawv yav tom ntej. Kev tswj nruj ntawm kev siv tshuaj ib zaug yog qhov tseem ceeb.

Rau warts ntawm qhov chaw mos los yog lub ncauj tsev menyuam, cov kev tshawb fawb soj ntsuam tau qhia meej tias tag nrho cov nyiaj ntawm ib daim ntawv thov ntawm 25% tshuaj yuav tsum tau tswj nyob rau hauv 0.5 mL, thiab daim ntawv thov cheeb tsam yuav tsum me me thiab ntiav. Qhov laj thawj tseem ceeb ntawm qhov txwv no yog los tiv thaiv cov tshuaj los ntawm kev nqus sai sai rau hauv cov hlab ntsha los ntawm cov hlab ntsha nplua nuj ntawm cov mucous membrane. Cov kab mob toxicity feem ntau cuam tshuam nrog ntau npaum li cas, ntau dhau ntawm lub cev saum npoo av, lossis lub siab tsis zoo lossis lub raum ua haujlwm hauv cov neeg mob. Yog li ntawd, thaum B2Bcov neeg siv khoom npaj rau cov chaw kho mob, lawv tsis yog tsuas yog yuav tsum tau npaj cov tshuaj kho kom tiav, tab sis feem ntau yuav tsum tau yuav cov khoom siv siab - purity cawv, roj av jelly, thiab cov cuab yeej ntsuas meej- txhua yam khoom siv tsis tau pom hauv cov txheej txheem kho mob.

Xaiv pebpodophyllum resin hmoovQhov tseem ceeb txhais tau tias xaiv qhov kev lees paub ntawm siab purity, siab stability, thiab siab ua raws li koj lub lag luam. Peb nruj me ntsis tswj lub hauv paus ntawm raw cov ntaub ntawv los xyuas kom meej batch - mus rau -batch sib xws ntawm active cov khoom xyaw; nyob rau sab ntau lawm, peb ntiav gradient extraction thiab qis -kub crystallization txheej txheem los tswj cov ntsiab lus ntawm podophyllotoxin nyob rau hauv qhov ntau yuav tsum tau los ntawm USP / BP qauv. Qhov tseem ceeb tshaj, txhua pawg ntawm peb cov khoom tuaj nrog Daim Ntawv Pov Thawj Ua tiav (COA) thiab MSDS, thiab peb muab kev pabcuam kev lis kev cai nrawm nrawm. Tiv tauj peb ntawminfo@kintaibio.com.