RauB2B cov neeg siv khoom, ceev nrooj txheeb xyuas cov khoom tseem ceeb nrog siab purity, ruaj khov khoom, thiab kev tsim nyog raws li kev lag luam raw khoom yog feem ntau tseem ceeb rau kev lag luam kev vam meej. Niaj hnub no, peb tsom mus rauFBP sodium (sodium fructose-1,6-bisphosphate), ib qho khoom siv raw khoom uas tau txais kev saib xyuas tseem ceeb hauv cov chaw muag tshuaj thiab cov khoom siv roj ntsha. Raws li qhov tseem ceeb nruab nrab ntawm txoj hauv kev glycolysis, nws tsis tsuas yog tuav lub hauv paus hauv paus hauv cov tshuaj classic vim nws cov khoom siv hluav taws xob zoo thiab cov khoom antioxidant, tab sis kuj qhia tau zoo kawg nkaus daim ntawv thov muaj peev xwm hauv kev txiav - cov ntawv thov xws li kab lis kev cai ntawm tes thiab cov tshuaj lom neeg.
FBP sodium yog dab tsi?
FBP sodium, luv rauD-fructose-1,6-bisphosphate trisodium ntsev, yog ib txwm tshwm sim ua haujlwm phosphate qab zib hauv cov kab mob nyob. Raws li ib qho tseem ceeb metabolic intermediate hauv glycolysis (txoj hauv kev tseem ceeb ntawm cov piam thaj tawg rau lub zog), nws tuav lub luag haujlwm tseem ceeb hauv cov metabolism hauv lub zog thiab yog tus thawj coj ncaj qha rau glyceraldehyde-3-phosphate thiab dihydroxyacetone phosphate. FBP sodium molecule muaj ob lub zog phosphate bonds, uas ua rau nws muaj kev ua haujlwm ntawm lub cev.
Txhawm rau kom cov khoom lag luam ruaj khov thiab yooj yim ntawm kev siv, cov khoom lag luam muaj cov khoom lag luam feem ntau muaj xws li hydrated trisodium ntsev, zoo li cov dawb los yog tawm - cov hmoov dawb nrog cov dej zoo solubility. Tus nqi tseem ceeb ntawm FBP sodium stems los ntawm nws cov xov tooj muaj zog - tiv thaiv thiab metabolic tswj kev ua haujlwm. Cov yam ntxwv no ua rau nws tsis yog tsuas yog cov tseem ceeb active ingredient nyob rau hauvtxhaj tshuaj fructose-1,6-bisphosphate sodiumkev npaj, siv kho mob raws li kev kho mob ntxiv rau myocardial ischemia thiab lub hlwb raug mob, tab sis kuj qhia tau hais tias muaj peev xwm siv dav hauv thaj chaw biopharmaceutical.
FBP sodium ua dab tsi?
Covmechanism ntawm kev txiav txim ntawm fructose-1,6-bisphosphate sodium (FBP sodium)Feem ntau revolves nyob ib ncig ntawm nws cov kev cai ntawm cellular zog metabolism thiab nws cellular tiv thaiv functions. Raws li qhov siab -zog phosphate compound, nws tuaj yeem ncaj qha nkag mus rau glycolysis txoj hauv kev, hla tus nqi - txwv enzyme phosphofructokinase (PFK). Nyob rau hauv lub zog- tsis muaj cov xwm txheej xws li ischemia thiab hypoxia, nws tau siv los ntawm cov hlwb sai ua cov txheej txheem exogenous, yog li rov ua haujlwm ntawm anaerobic glycolysis thiab nce intracellular ATP (adenosine triphosphate) ntau lawm.
Tsis tas li ntawd,FBP sodium hmoovzoo tswj cov txheej txheem kev ncaj ncees thiab permeability ntawm cov cell membrane los ntawm stabilizing phospholipid bilayer thiab inhibiting oxygen -dawb radical-induced lipid peroxidation, txo cov to ntawm intracellular enzymes thiab metabolites. Nyob rau tib lub sijhawm, nws tuaj yeem tswj hwm pH ntawm lub cev, txo cov acidosis kev puas tsuaj los ntawm lactic acid tsub zuj zuj, thiab inhibit apoptosis signaling txoj kev tshwm sim los ntawm calcium overload. Yog li ntawd, los ntawm tag nrho cov txiaj ntsig kev pom,FBPsodium tsis ncaj qha ua rau cov receptors tshwj xeeb tab sis theej siv nws txoj kev tiv thaiv ntawm ischemic thiab hypoxic cov ntaub so ntswg los ntawm ntau lub tswv yim, suav nrog kev txhim kho cov metabolism hauv lub zog ntawm lub zog -cov hlwb tsis txaus, stabilizing membrane qauv, thiab antioxidation.
Puas yog FBP sodium zoo rau cov hlab plawv?
Yog lawm, kev tshawb fawb thiab kev siv tshuaj kho mob uas twb muaj lawm tau pom tiasFBP sodiummuaj kev tiv thaiv tseem ceeb thiab ua kom muaj txiaj ntsig zoo ntawm cov hlab plawv. Tshwj xeeb tshaj yog nyob rau hauv pathological xeev xws li myocardial ischemia thiab hypoxia, nws plays lub luag haujlwm tseem ceeb hauv kev txhawb nqa metabolic thiab kev tiv thaiv ntawm tes. Raws li cov tshuaj mob plawv pom zoo los ntawm National Medical Products Administration, fructose diphosphate sodium txhaj tshwj xeeb yog qhia tshwj xeeb rau kev txhim kho angina pectoris, mob myocardial infarction, arrhythmia, thiab myocardial ischemia cuam tshuam nrog lub plawv tsis ua haujlwm hauv cov neeg mob plawv.
Nws lub hauv paustshuabnyob rau hauv qhov tseeb hais tias exogenousFBP sodiumtuaj yeem hla tus nqi - txwv cov kauj ruam hauv txoj hauv kev glycolysis, ncaj qha muab siab - lub zog substrates rau ischemic cardiomyocytes, nce qib hauv cov cellular ATP thiab phosphocreatine. Qhov no tsis tsuas yog muab lub zog ncaj qha rau cov neeg tuag cardiomyocytes los tswj lawv cov qauv thiab kev ua haujlwm, tab sis kuj txo cov cell puas los ntawm ischemia -reperfusion los ntawm stabilizing lub cardiomyocyte membrane thiab inhibiting tso tawm cov pa phem dawb radicals thiab histamine.
ntev npaum li cas rau FBP yuav siv tau?
Lub sijhawm pib ntawmfructose-1,6-bisphosphate sodium (FBP sodium)Nws txawv nyob ntawm txoj kev tswj hwm, kev qhia, thiab tus neeg mob sib txawv. Intravenous tswj muab qhov pib sai tshaj plaws ntawm kev ua. Pharmacokinetic cov ntaub ntawv txhawb nqa qhov pib sai sai no: hauv cov neeg ua haujlwm noj qab haus huv, qhov siab tshaj plaws ntawm cov ntshav ntshav tau mus txog li 5 feeb ntawm kev txhaj tshuaj hauv cov hlab ntsha, thiab cov ntshav ib nrab- lub neej yog kwv yees li 10-15 feeb, txhais tau tias cov tshuaj tuaj yeem faib tau sai rau cov ntaub so ntswg ischemic thiab siv nws cov nyhuv. Qhov pib sai sai no yog qhov tseem ceeb hauv kev kho mob rau cov neeg mob uas mob myocardial ischemia, myocardial infarction, thiab lwm yam mob hnyav thiab mob hnyav.
Cov tshuaj hauv qhov ncauj, txawm li cas los xij, xav tau kev nqus ntawm plab hnyuv thiab muaj qhov pib ua haujlwm qeeb qeeb, feem ntau qhia tau hais tias muaj txiaj ntsig 1-2 lub lis piam tom qab kev tswj hwm, nrog rau qhov siab tshaj plaws plasma concentration txog li 51 feeb. Rau cov neeg mob rov zoo los ntawm lub plawv tsis ua hauj lwm, cardiomyopathy, lossis mob hlwb, kev txhawb zog txuas ntxiv yog xav tau rau kev kho cov ntaub so ntswg,FBPfeem ntau xav tau lub lis piam mus rau lub hlis ntawm kev siv tas li kom ua tiav kev ua haujlwm tseem ceeb. Feem ntau, kev tswj hwm txoj hlab ntshav yog tsim nyog rau cov mob ischemic xeev uas xav tau kev cuam tshuam sai, thaum cov qauv ntawm qhov ncauj yog qhov tsim nyog rau lub sijhawm ntev - txhawb zog thiab kho cov ntaub so ntswg.
FBP trisodium ntsev ntau npaum li cas ib hnub?
CovKev noj tshuaj txhua hnub ntawm fructose-1,6-bisphosphate trisodium ntsev (FBP trisodium ntsev)Nws txawv nyob ntawm txoj kev ntawm kev tswj hwm, kev qhia, thiab tus neeg mob tus mob tshwj xeeb, thiab yuav tsum tau txiav txim siab raws li kev taw qhia ntawm tus kws kho mob. Intravenous tswj yog txoj kev siv ntau tshaj plaws hauv kev kho mob. Cov tshuaj niaj hnub ntawm txhaj tshuajfructose-1,6-bisphosphate sodium yog 5-10 grams(xws li FBP) ib koob tshuaj, muab los ntawm kev txhaj tshuaj infusion lossis twj tso kua mis. Rau cov mob hnyav thiab mob hnyav xws li mob myocardial infarction thiab myocardial ischemia, feem ntau yog siv 1-2 zaug hauv ib hnub rau 3-7 hnub sib law liag, nrog rau cov kev kho tshwj xeeb tau txiav txim siab raws li tus neeg mob tus mob.
Qhov pom zoo npaum li cas rau qhov ncauj formulations kuj qis dua. Hauv kev tshawb fawb soj ntsuam, feem ntau siv tshuaj rau qhov ncaujfructose-1,6-bisphosphate sodium formulations (xws li tshuaj ntsiav thiab hmoov)yog 1-2 grams ib koob, 2-3 zaug ib hnub twg, rau tag nrho cov koob tshuaj txhua hnub ntawm 2-6 grams. Vim muaj kev txwv qhov ncauj bioavailability (kwv yees li 10% – 15%), qhov koob tshuaj no yog tsim rau ntev - lub sij hawm metabolic txhawb rau cov neeg mob uas muaj lub plawv tsis ua hauj lwm, cov kab mob plawv ruaj khov, lossis cov neeg uas rov qab los ntawm lub hlwb raug mob, thiab feem ntau yuav tsum tau ua haujlwm tas mus li ntau tshaj 4 lub lis piam kom ua tiav kev ua haujlwm tseem ceeb.
Qhov twg yuav qhov zoo tshaj plaws FBP sodium hmoov?
Thaum xaivfructose-1,6-bisphosphate trisodium ntsev (FBP)Raws li cov khoom siv raw, thov hu rau Healthkintai. Peb cov ntaub ntawv FBP siv cov txheej txheem enzymatic catalysis thiab crystallization, ua kom cov khoom purity ntau dua los yog sib npaug li 99%, ua tau raws li cov kws kho mob siab - cov qauv qib. Txhua batch los nrog ib tug thib peb -daim ntawv pov thawj ntawm tus account (COA), nrog hnyav hlau thiab hnyav residues nruj me ntsis tswj nyob rau hauv kev txwv. Peb tuaj yeem lav kev xa khoom sai ntawm gram- cov qauv ntsuas mus rau ton- qib xaj. Kev xaiv peb txhais tau tias tsis yog xaiv cov khoom siv siab tshaj -purity core raw, tab sis kuj xaiv ib tus khub txhim khu kev qha rau koj cov qauv tsim thiab kev tsim khoom lag luam.Tiv tauj pebntawminfo@kintaibio.com.
