Coenzyme Q10 Cov txiaj ntsig rau Fertility

Raws li cov ntaub ntawv los ntawm Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv, kwv yees li 17.5% ntawm cov neeg laus hauv ntiaj teb no raug kev txom nyem los ntawm kev xeeb tub, thiab qhov kev faib ua feem no nce zuj zus. Coenzyme Q10 (CoQ10), nrog nws ob lub luag haujlwm hauv cellular zog metabolism thiab tiv thaiv antioxidant, tau nce los ntawm cov khoom noj khoom haus hauv plawv mus rau lub hnub qub raw khoom hauv cov khoom noj khoom haus me nyuam. Peb yog cov chaw tsim khoom thiab chaw muag khoom ntawm Coenzyme Q10, muab koj cov khoom zoo - zoo raw khoom. Tiv tauj peb ntawminfo@kintaibio.com.

Coenzyme Q10yog ib qho lipid-soluble benzoquinone compound pom nyob rau hauv tag nrho cov eukaryotic hlwb, ua si ob lub ntsiab physiological functions nyob rau hauv tib neeg lub cev: mitochondrial zog metabolism thiab tiv thaiv antioxidant. Ob txoj haujlwm no ua ke ua lub hauv paus rau coenzyme Q10 lub luag haujlwm hauv kev txhawb nqa kev noj qab haus huv.Lub oocyte muaj qhov ceev tshaj plaws mitochondrial hauv tib neeg lub cev. Oocyte maturation, fertilization, thiab thaum ntxov embryonic txoj kev loj hlob tag nrho yuav tsum muaj ntau ntawm ATP. Cov phev kuj xav tau lub zog txaus los txhawb lawv txoj kev txav mus los thiab muaj peev xwm fertilization. Thaum intracellular coenzyme Q10 qib txaus, mitochondrial zog ntau lawm efficiency yog siab dua, muab lub zog muaj zog txhawb rau cov qe menyuam.

Oxidative stress yog ib qho tseem ceeb uas ua rau muaj menyuam tsis taus. Hauv cov poj niam, ROS ntau dhau tuaj yeem ua rau oocyte zoo thiab ua kom lub zes qe menyuam laus; Hauv cov txiv neej, ROS cuam tshuam rau cov spermatogenesis, ua rau cov phev txawv txav morphology thiab kev ua haujlwm tsis zoo.Lub cev lub cev endogenous coenzyme Q10 synthesis muaj peev xwm poob qis nrog hnub nyoog. Qhov no txhais tau hais tias exogenous coenzyme Q10 supplementation muaj qhov cuam tshuam tseem ceeb rau cov poj niam laus sim xeeb tub lossis cov tib neeg uas muaj kev ua me nyuam me me. Nws muab kev tiv thaiv dual rau kev noj qab haus huv ntawm cov menyuam yaus los ntawm kev rov ua kom lub zog ntawm tes thiab ua kom tsis muaj zog oxidative puas tsuaj.

Ib feem tseem ceeb ntawm txiv neej infertility yog idiopathic txiv neej infertility nrog tsis paub ua. Nyob rau hauv xyoo tas los no, ntau qhov siab - cov kev tshawb fawb soj ntsuam zoo tau lees paub tias coenzyme Q10 supplementation muaj txiaj ntsig zoo rau kev txhim kho txiv neej fertility. Hais txog kev txhim kho cov phev concentration, coenzyme Q10 yog qhov kev cuam tshuam zoo tshaj plaws ntawm tag nrho cov tshuaj antioxidants. Kev kho mob ntev tshaj li 3 lub hlis txhim kho cov phev morphology (p<0.05). This means that product development targeting male reproductive health should recommend a minimum 3-month treatment period for optimal results.

Qhov chaw:https://www.mdpi.com/2076-3921/10/6/874

Hauv thaj teb ntawm poj niam fertility, kev tshawb fawb ntawm CoQ10 kuj tau txais txiaj ntsig zoo. Nws txhawb oocyte maturation los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab txo oxidative kev nyuaj siab. Cov kev tshawb fawb hauv vitro tau pom tias ntxiv 50 μM CoQ10 rau cov kab lis kev cai nruab nrab nce oocyte thawj lub cev nqaij daim tawv extrusion tus nqi los ntawm 48.9% mus rau 75.7%, thaum tib lub sij hawm txo qis apoptosis marker theem.CoQ10 supplementation tuaj yeem txhim kho zes qe menyuam muaj nuj nqi thiab nce tus naj npawb ntawm oocytes retrieved, tshwj xeeb tshaj yog rau cov poj niam uas muaj hnub nyoog li qub. Los ntawm kev ua kom zoo oocyte zoo, nws tuaj yeem txhim kho embryonic kev loj hlob muaj peev xwm thiab kev kuaj mob cev xeeb tub. Cov kev tshawb fawb ntawm cov poj niam uas muaj PCOS (polycystic zes qe menyuam syndrome) tau pom tias CoQ10 supplementation tuaj yeem txo qis cov tshuaj insulin thiab insulin tsis kam, thiab nce PPAR{12}} qhia. Nws yog tshwj xeeb tshaj yog tsim nyog raws li kev kho mob ntxiv rau cov poj niam hnub nyoog tshaj 35 xyoo, nrog txo qis qis ntawm zes qe menyuam, cov neeg uas muaj cov lus teb tsis zoo rau yav dhau los ovulation induction, lossis cov uas muaj PCOS.

Qhov chaw:https://www.frontiersin.org/

Tam sim no, kev ua lag luam rauCoenzyme Q10cov khoom lag luam tsom mus rau kev noj qab haus huv ntawm cov menyuam yaus nthuav tawm ntau hom toj roob hauv pes. Cov khoom lag luam muaj xws li softgels, tawv capsules, ntsiav tshuaj, thiab hmoov. Rau cov uas sim xeeb tub, txo Coenzyme Q10 (panthenol) tau nce zuj zus los ua cov khoom muaj nyob hauv cov khoom siab - kawg. Piv nrog rau daim ntawv oxidized ib txwm (ubiquinone), panthenol tuaj yeem nqus tau ncaj qha yam tsis muaj kev hloov pauv hauv lub cev, ua rau muaj bioavailability ntau dua, ua rau nws tshwj xeeb tshaj yog rau cov neeg laus lossis cov neeg uas muaj qhov nqus nqus tsawg.

Txhawm rau txhim kho kev sib koom ua ke, cov khoom lag luam ntau ntxiv ua ke Coenzyme Q10 nrog rau lwm cov khoom xyaw fertility, xws li L-carnitine (cov kev tshawb fawb pom tias nws tuaj yeem txhim kho cov phev tsis muaj zog), vitamin E (txhim kho cov kab mob antioxidant), thiab cov kab mob xws li folic acid, zinc, thiab selenium, tsim kom muaj cov khoom noj muaj txiaj ntsig zoo tshaj plaws ntawm B2. formulation yooj- nws tuaj yeem tsim ua softgels, tawv capsules, chewable tablets, effervescent ntsiav tshuaj, los yog siv los ua ib feem ntawm cov dej haus kom tau raws li cov kev nyiam ntawm ntau pawg neeg siv.

Precise dosage design yog lub hauv paus ntawm cov khoom siv tau zoo thiab kev nyab xeeb. Rau cov poj niam uas npaj rau cev xeeb tub/pab txhawb kev yug menyuam, cov koob tshuaj txhua hnub pom zoo yog 100-200 mg, muab faib ua ob koob. Haum rau cov poj niam hnub nyoog 30-35 uas muaj lub zes qe menyuam ua haujlwm raws li kev tiv thaiv ntxiv. Rau cov poj niam uas muaj hnub nyoog siab tshaj (Ntau dua lossis sib npaug li 35 xyoos), cov neeg uas muaj qhov txo qis ntawm zes qe menyuam, lossis cov uas muaj IVF / ICSI cycles, cov koob tshuaj uas nquag siv hauv kev tshawb fawb soj ntsuam yog 600 mg ib hnub (raug faib ua peb koob, rau 60 hnub). Supplementation regimens kav ntev dua 3 lub hlis yog qhov zoo tshaj plaws hauv kev txhim kho phev morphology. Nws kuj tseem pom zoo kom noj nrog zaub mov kom txhim kho qhov nqus ntawm cov rog-soluble coenzyme Q10.

Ubiquinone:Classic daim ntawv, kev ruaj ntseg zoo, tus nqi nruab nrab, haum rau cov khoom siv kho mob.
Panthenol:Ntau dua bioavailability, ncaj qha cuam tshuam, tshwj xeeb tshaj yog haum rau siab - cov khoom kawg tsom rau cov poj niam laus uas sim xeeb tub los yog cov uas tsis muaj peev xwm ua me nyuam.
Dej-soluble/liposome technology:Txhim kho tus nqi nqus los ntawm cov txheej txheem tshwj xeeb, tuaj yeem siv los ua qhov sib txawv ntawm qhov muag.
Healthkintai® muaj ntau qhov ntau thiab tsawg ntawm Coenzyme Q10. Nyem qhov no kom paub ntau ntxiv.

Peb tswj hwm kev tswj hwm zoo los ntawm qhov chaw, ua kom txhua tus Coenzyme Q10 yog tsim los siv thib peb- tiam microbial fermentation technology, lav ntau dua bioavailability thiab kev nyab xeeb.Peb muaj ntau yam khoom, los ntawm 98% siab -purity pharmaceutical- qib hmoov rau customized 10% dej-soluble formulations, lipase 8 / lipid soluble formulation xav tau los ntawm kev noj qab haus huv ntxiv rau siab -kawg kev noj qab haus huv kev noj qab haus huv.Qhov tseem ceeb tshaj, txhua batch los nrog ib tug thib peb-HPLC xeem tsab ntawv ceeb toom thiab thoob ntiaj teb cov ntawv pov thawj (ISO, HACCP, HALAL, thiab lwm yam). Peb tsis yog tsuas yog ib tug raw khoom, tab sis kuj muab ib tug - nres kev pab cuam, kev ruaj ntseg kev lag luam, kev ruaj ntseg kev lag luam, thiab kev tsim kho sai. nrog tus nqi tseem ceeb kom zoo dua. YuavCoenzyme Q10 hmoov, Tiv tauj peb ntawminfo@kintaibio.com.