L-5-MTHF-Ca L Methylfolate Calcium Powder Chaw tsim tshuaj paus / Hoobkas / Tus neeg muag khoom
Methyltetrahydrofolateyog tag nrho cov tshuaj npe rau methyltetrahydrofolic acid, feem ntau abbreviated li5- MTHFhauv kev lag luam. Nws poob rau hauv qeb ntawmactive folate. Cov tshuaj no muaj ob lub stereoisomers: L-form thiab D- daim ntawv, ntawm cov uas tsuas yog L- daim ntawv muaj lub cev muaj zog.
Qhov feem ntau xa mus rauMethylfolatethiabL-Methylfolatetshwj xeeb txhais tau tias bioavailable levorotatory isomer uas tuaj yeem siv los ntawm tib neeg lub cev. Nws lub npe tus qauv yogL-5-MTHF, thiab nws cov tshuaj alias yogLevomefolic acid. (L Methylfolate Vs 5 MTHF)
Noj qab haus huv®'s cov khoom tseem ceeb yogL-5-MTHF-Ca L Methylfolate Calcium Powder, tsim nrog L-5-MTHF nquag monomer ua cov khoom siv raw. Piv nrog rau cov dawb acid daim ntawv, nws cov calcium ntsev nta superior stability, ntev txee lub neej thiab dav siv. Cov khoom tiav ib purity ntawm98%–99%, tsuas yog muaj 6S nquag isomer uas tsis muaj txiaj ntsig D-daim ntawv impurities. Ua raws li USP thiab EP cov qauv tshuaj pharmacopoeia, nws yog cov khoom siv folate uas nyiam tshaj plaws rau cov khoom noj qab haus huv siab -kawg, cov chaw muag tshuaj thiab cov chaw tsim khoom noj khoom haus thoob ntiaj teb.
Tiv tauj pebntawmhealth@kintaibio.com rau tus qauv dawb tam sim no.
Calcium L Methylfolate Vs 5 MTHF
5-MTHF dawb acidthiabL-methylfolate calciumqhia tib cov khoom xyaw tseem ceeb, uas yog lub cev muaj zog 6S levorotatory isomer, yog li lawv muab cov txiaj ntsig zoo ib yam. Qhov sib txawv tseem ceeb nyob hauv lawv cov ntaub ntawv tshuaj. Raws li tus thawj cov kua qaub dawb, 5-MTHF muaj kev ruaj ntseg tsis zoo, dej solubility thiab formulation compatibility, nrog rau stringent cia yuav tsum, thiab yog tsuas yog siv rau kev kuaj sim thiab kev cai formulations. Nyob rau hauv sib piv, L-methylfolate calcium, ib tug calcium ntsev derivative, boasts superior physicochemical zog thiab dav siv tau, ua rau nws lub mainstream coj mus muag raw khoom rau kev noj haus tshuaj, tshuaj thiab lwm yam khoom.
| Cov khoom sib piv | 5-MTHF (Dawb Acid) | Calcium L-Methylfolate (L-5-MTHF-Ca) |
| Daim ntawv tshuaj | Dawb Acid | Calcium ntsev |
| Cov khoom xyaw nquag | L-5-MTHF (6S nquag isomer) | L-5-MTHF (6S nquag isomer, tsis muaj D-form impurities) |
| Kev ua ntawm lub cev | Bioactive rau tib neeg lub cev | Kev ua haujlwm zoo ib yam; yuav siv tau tom qab dissociation hauv vivo |
| Kev ruaj ntseg | Tsis zoo, nquag oxidation thiab decomposition los ntawm noo noo | Zoo heev, tiv thaiv -oxidative, tshav kub-resistant thiab tsis yog-hygroscopic |
| Txee lub neej | luv luv, yuav tsum tau nruj me ntsis cia tej yam kev mob | Ntev, haum rau ntev - lub sij hawm cia nyob rau hauv ib txwm tej yam kev mob |
| Solubility | Solubility ntawm dej | Cov dej solubility zoo dua |
| Formulation Compatibility | Reacts yooj yim nrog cov ntaub ntawv acidic, txwv daim ntawv thov | Tau tshaj cov kua qaub thiab alkaline tshuab, dav siv tau |
| Cov ntawv thov tseem ceeb | Laboratory siv & customized siab - kawg formulations | Cov khoom noj khoom haus, tshuaj thiab khoom noj kho mob (cov khoom lag luam tseem ceeb) |
| Kev Ua Raws Cai | Ua raws li USP / EP | nruj me ntsis raws li USP / EP cov qauv tshuaj pharmacopoeia |
Regulatory Status of L-5-MTHF-Ca L Methylfolate Calcium Powder
JECFA (Joint FAO / WHO Cov Kws Tshaj Lij Pabcuam ntawm Cov Khoom Noj Ntxiv)
Pawg neeg ua tiav qhov kev ntsuam xyuas kev nyab xeeb ntawmL-5-methylfolate calciumnyob rau hauv 2005. Nws xaus lus tias cov khoom posestsis muaj zaub mov txaus ntshai, thiab pom zoo nws siv nyob rau hauv cov ntaub ntawv xws li muaju thiab microcapsules rau kev noj haus tshuaj, tshwj xeeb noj cov zaub mov thiab cov zaub mov fortification.
US FDA
L-5-methylfolate calciumua tauGRAS(Feem ntau pom tau tias muaj kev nyab xeeb) raws li txoj cai hauv Tebchaws Meskas thiab tau tso cai rau kev ntxiv rau cov khoom noj khoom haus. Nws tau sau npe ua ib tugCov khoom noj tshiab tshiabXyoo 2001. Muaj nyob rau hauv USP Dietary Supplement Compendium, cov folate nquag no tuaj yeem siv dav hauv cov khoom noj khoom haus, khoom noj khoom haus thiab cov khoom siv tshuaj.
EFSA (European Food Safety Authority)
EFSA lees paub qhov kev nyab xeeb ntawm cov khoom xyaw no thiab teeb tsa qhov siab tshaj plaws noj txhua hnub ntawm 1 mg rau cov neeg laus. Nws tau pom zoo siv rau hauv cov khoom noj, cov khoom noj muaj zog, cov mis mos thiab cov khoom noj rau cov hom phiaj kho mob tshwj xeeb.
Cov txiaj ntsig ntawm L-5-MTHF yog dab tsi?
L-Methylfolate rau cev xeeb tub
L-Methylfolate rau MTHFR
L-methylfolate yog hom folate uas muaj peev xwm ua tau ncaj qha rau hauv lub voj voog methylation uas tsis muaj catalytic activation los ntawm MTHFR enzyme. Rau cov poj niam sim xeeb tub los yog thaum cev xeeb tub uas nqaMTHFR noob mutationsthiab raug kev txom nyem los ntawm kev ua haujlwm tsis txaus enzyme, ua rau cov hluavtaws folate yooj yim los hloov thiab siv,L-methylfolatebypasses metabolic bottlenecks kom sai txo cov teeb meem homocysteine nyob rau hauv lub cev. Nws tsis tu ncua tswj cov txheej txheem folate metabolism hauv leej niam lub cev, tiv thaiv cov kab mob metabolic tshwm sim los ntawm kev ua haujlwm tsis zoo ntawm folate, thiab tuaj yeem hla cov placenta kom xa cov as-ham ncaj qha rau tus menyuam hauv plab, hais txog qhov teeb meem tseem ceeb ntawm kev nqus folate tsis txaus thiab siv rau cov neeg uas muaj caj ces.
L Methylfolate rau Fertility
Txaus activeL-methylfolatealleviates kev puas tsuaj rau cov kab mob hlwb induced los ntawm elevated homocysteine , optimizes zes qe menyuam ib puag ncig, txhim kho oocyte zoo, txhim khu endometrial receptivity, pab txhawb lub embryo implantation thiab zoo boosts lub sij hawm ntawm ntuj conception. Tom qab ua tiavcev xeeb tub, cov pab pawg methyl nws muab kev txhawb nqa fetal DNA synthesis thiab kev sib txawv ntawm cov hlab ntsha neural, kab mob plawv thiab ntau yam kabmob. Nws tiv thaiv cov kab mob neural tsis xws li spina bifida thiab anencephaly thaum lub sij hawm tseem ceeb thawj peb lub hlis twg, thiab txo qhov tshwm sim tsis zoo ntawm cev xeeb tub uas tshwm sim los ntawm homocysteine siab nrog rau kev nchuav menyuam, raug ntes, gestational hypertension thiab tsis txaus cov ntshav placental, kev tiv thaiv kev xeeb tub ntawm cev xeeb tub thoob plaws hauv lub cev {1}.
L Methylfolate rau menyuam yaus
L Methylfolate rau ADHD
Raws li cov tshuaj lom neeg muaj pes tsawg leeg ntawm folate, L-methylfolate muab cov tshuaj methyl tseem ceeb rau DNA synthesis thiab myelin kev loj hlob ntawm paj hlwb hauv cov menyuam yaus hippocampus thiab prefrontal cortex. Cov menyuam yaus uas tsis muaj zog MTHFR noob txawv tsis tuaj yeem ua kom zoo li qub folic acid, ua rau muaj cov homocysteine ntau ntau hauv lub cev, uas ua rau lub paj hlwb tsis zoo thiab cuam tshuam rau lub hlwb cov teeb liab hloov, tshwm sim raws li cov tsos mob ntawm ADHD classic suav nrog kev tsis txaus siab, kev coj cwj pwm tsis zoo thiab tsis xis nyob. Ntxiv nrog rau L-methylfolate bypasses metabolic defects kom sai txo homocysteine ntau ntau, kho puas neural pathways thiab txhim kho cov efficiency ntawm lub hlwb teeb liab kis tau tus mob, fundamentally alleviating ADHD manifestations xws li distractibility, hyperactivity thiab tsis zoo tus kheej - tswj cov me nyuam.
L Methylfolate rau Kev ntxhov siab
Lub synthesis ntawm mus ob peb vas - tswj cov neurotransmitters xws li dopamine thiab serotonin nyob rau hauv lub hlwb yog heev nyob rau hauv cov khoom ntawm methyl pawg. Kev cuam tshuam cov folate metabolism ncaj qha inhibits kev tsim tawm ntawm ob lub neurotransmitters, ua rau cov menyuam yaus muaj kev xav, chim siab thiab ua rau muaj kev ntxhov siab thiab tsis xis nyob.L-methylfolatetsis tu ncua muab ntau cov methyl precursors los txhawb kev ruaj khov ntawm serotonin thiab dopamine, sib npaug ntawm lub hlwb txoj kev xav, thiab txo cov kev xav tsis zoo nrog rau kev ua siab ntev, chim siab thiab quaj hauv cov menyuam yaus. Tsis tas li ntawd, daim folate nquag no txhawb hematopoiesis thiab kev tiv thaiv kab mob, thiab ib txhij txhawb kev loj hlob ntawm - lub sij hawm noj qab haus huv ntawm cov me nyuam txoj kev txawj ntse thiab pob txha.
L Methylfolate rau Kev Nyuaj Siab
Feem ntau cov neeg nrogkev nyuaj siabFeem ntau pom muaj kev cuam tshuam cov metabolism lossis kev hloov pauv caj ces ntawm MTHFR gene, uas cuam tshuam ncaj qha rau kev sib txuas thiab tso tawm ntawm peb lub siab xav -txog neurotransmitters: serotonin, dopamine, thiab norepinephrine. Kev tso tawm tsis txaus ntawm cov neurotransmitters ua rau muaj qhov tsis txaus ntseeg hauv kev tswj hwm kev xav, uas tshwm sim raws li cov tsos mob ntawm kev nyuaj siab nrog rau kev xav tsis zoo, anhedonia, sab hauv emptiness, pessimism thiab kev ntxhov siab, thiab kev xav qeeb. Qee cov neeg mob kuj muaj cov teeb meem sib thooj xws li kev pw tsaug zog tsis zoo, kev puas siab puas ntsws, thiab kev chim siab.
NtxivL-methylfolatemuab cov txiaj ntsig zoo dua: ntawm ib sab, nws ua kom zoo dua thiab tshem tawm ntau homocysteine hauv lub cev kom txo tau cov kab mob neurotoxicity thiab kho cov kab mob neural teeb liab kev puas tsuaj; Ntawm qhov tod tes, nws pab txhawb kev tsim cov paj hlwb neurotransmitters, tsis tu ncua nce cerebral concentrations ntawm serotonin, dopamine thiab lwm yam transmitters kom sib npaug hauv nruab nrab kev xav hauv lub hlwb. Nws ameliorates kev nyuaj siab predispositions nyob rau hauv lub hauv paus metabolic theem, alleviating me mus rau nruab nrab kev nyuaj siab, tsis tshua muaj mus ob peb vas thiab ntxhov siab vim. Tsis tas li ntawd, nws txhawb kev ua tau zoo ntawm cov tshuaj tiv thaiv kev ntxhov siab, txhim kho kev pw tsaug zog zoo thiab lub siab lub ntsws tseem ceeb hauv cov neeg muaj kev nyuaj siab, thiab txo qis kev ntxhov siab ntau zaus.
L-5-MTHF-Ca L Methylfolate Calcium Powder Siv
Hauv Pharmaceuticals
L-methylfolate calcium yog cov tshuaj pharmacopoeia- qib active folate API ncaj qha siv rau hauv kev tsim cov tshuaj, khoom noj kho mob thiab kev npaj kho mob tshwj xeeb. Cov khoom siv kho mob kawg suav nrog cov tshuaj noj - qibL-methylfolate ntsiav tshuaj(7.5mg / 15mg specifications), cov khoom noj kho mob rau kev kho mob kev nyuaj siab, tshwj xeeb formulations rau hyperhomocysteineemia, thiab tsom folate- kho cov tshuaj rau cov neeg mob uas muaj MTHFR noob tsis xws luag. Nws kuj tuaj yeem ua ke nrogmethylcobalaminthiabpyridoxal 5'-phosphatelos tsim cov tshuaj tiv thaiv kab mob plawv thiab cerebrovascular. Tsis tas li ntawd, nws ua haujlwm tseem ceeb hauv cov tshuaj txhaj tshuaj thiab tshuaj tua kab mob hauv qhov ncauj rau kev kho folate- tsis txaus megaloblastic anemia.
Hauv Cov Khoom Noj Khoom Haus
L-methylfolate calciumboasts qhov zoo ntawm bioavailability siab. Nws cov khoom tseem ceeb kawg poob mus rau plaub qhov tseem ceeb: premium pre- cev xeeb tub thiab prenatal active folate ntsiav tshuaj, nrog rau compound prenatal multivitamin softgels; methylation- txhawb kev sib xyaw B-vitamin hmoov thiab tshuaj ntsiav; Cov ntsiav tshuaj kho mob plawv rau nruab nrab- cov neeg laus thiab cov neeg laus (formulated nrog methylcobalamin,Coenzyme Q10thiab ntses roj); cov kua hauv qhov ncauj rau kev tswj kev xav thiab kev paub txog kev txhawb nqa. Nws kuj tseem muaj nyob rau hauv cov qauv yooj yim nrog rau cov dej haus tam sim, cov ntsiav tshuaj chewable thiab probiotic complex nutrient hmoov. Microencapsulated raw khoom hais txog qhov teeb meem ntawm daim duab -oxidation ntawm folate.
Hauv Cov Khoom Noj Me Nyuam Me & Cov Khoom Noj Me Nyuam Me
Nrog rau kev pom zoo kev nyab xeeb zaub mov tau tso cai los ntawm EU thiab cov tub ceev xwm hauv tsev,L-methylfolate calciumtuaj yeem siv tau zoo rau cov khoom noj khoom haus rau cov menyuam mos thiab menyuam yaus hnub nyoog 0-12 xyoos. Cov khoom kawg npog theem 1 / theem 2 me nyuam mos mis hmoov hmoov, me nyuam mos cereal nplej hmoov, cov me nyuam cov tshuaj multivitamin chewable ntsiav tshuaj, kua vitamin tee rau cov me nyuam, cov ntsiav tshuaj loj hlob, thiab lub hlwb- txhawb nqa cov dej haus rau tsev kawm ntawv - cov me nyuam hnub nyoog. Cov khoom siv tshuaj tsawg tsawg - ua raws li cov qauv kev zam rau cov menyuam mos, hais txog cov menyuam yaus lub peev xwm tsis muaj zog los hloov folate, thiab txo cov kev pheej hmoo ntawm kev tsis txaus siab thiab kev loj hlob qeeb hauv cov tub ntxhais hluas.
Qhov twg Yuav Qhov Zoo Tshaj L-5-MTHF-Ca L Methylfolate Calcium Powder?
Noj qab haus huv®yog koom nrog kev lag luam ntawm cov tshuaj nruab nrab thiab cov khoom noj khoom haus ntxiv raw khoom, kev sib koom ua ke ntawm kev ywj pheej R & D, cov qauv tsim thiab kev muag khoom thoob ntiaj teb los muab ib qho - nres cov khoom siab - cov khoom zoo folate raw khoom -L-5-MTHF-Ca L Methylfolate Calcium Powder.
Kev siv cov txheej txheem kev sib xyaw ua ke zoo heev, cov khoom lag luam muaj qhov ua kom huv si levorotatory active configuration nrog D- hom inactive impurities kom huv si tshem tawm. Nws purity yog ruaj khovntawm 98% thiab 99%. Raws li calcium ntsev, nws boasts superior physicochemical stability thiab yog sib xws nrog kev tsim kho ntawm ntau yam kev npaj.
Tag nrho cov saw hlau ntau lawm yog nruj me ntsis tswj raws liGMPcov qauv, txhawb nqa los ntawm cov txheej txheem tag nrho ntawm cov ntawv pov thawj tsim nyog. Ua tiav daim ntawv pov thawj kev xeem raug muab tawm rau txhua pawg, uas muaj cov khoom tsawg kawg nkaus -rau -batch sib txawv thiab tswj cov ntsiab lus hloov pauv. Nws yog dav siv nyob rau hauv kws tshuaj intermediates, khoom noj khoom haus ua ntej yug menyuam thiab tom qab yug me nyuam, multi-B complex dietary supplements thiab lwm yam kev siv.
Rov qab los ntawm tus kheej-tsim thev naus laus zis thiab loj- cov kab ntau lawm, peb xa cov khoom lag luam zoo ib yam nrog cov kev pabcuam customized, ua rau peb ntev -cov khoom siv raw khoom ntseeg siab rau kev lag luam nutraceutical thiab kws tshuaj. Thov koj txhob xav li castiv tauj pebntawm
health@kintaibio.comrau kev nug thiab kev yuav khoom.
FAQ
Q: Vim li cas l methylfolate thiaj li kim?
A: Methylfolate (6S-5-methyltetrahydrofolate) yog tus nqi siab dua li cov khoom siv hluavtaws folic acid vim muaj ntau yam kev txwv siab ntawm nws cov tub ntxhais: nws yog cov khoom siv roj ntsha hauv lub cev ntawm folate, uas nws cov khoom tsim muaj ntau yam txheej txheem xws li txo qis, methylation. Tsuas yog 6S levorotatory isomer muaj kev ua haujlwm lom neeg, ua rau cov khoom siv poob loj heev thaum daws teeb meem. Multi- txheej chromatography thiab recrystallization yuav tsum tau tshem tawm cov hlau hnyav thiab cov txheej txheem impurities, ua rau kom cov nqi purification ntau heev. Ntxiv mus, cov khoom no muaj kev cuam tshuam rau oxidative degradation thaum raug lub teeb, cua sov thiab oxygen, yog li tag nrho cov txheej txheem ntawm kev tsim, sau thiab khaws cia yuav tsum tau ua nyob rau hauv lub teeb pom kev zoo - pov thawj, oxygen- cais thiab kub-tswj tej yam kev mob, uas zoo heev nce nqi ntawm cov khoom pab thiab ntim.
Q: Puas yog l-5-methyltetrahydrofolate tib yam li methylfolate?
A: L-5-methyltetrahydrofolate thiab methylfolate muaj nyob rau hauv kev ua lag luam yog qhov tseem ceeb tib yam active folate, feem ntau luv luv rau methylfolate hauv kev lag luam. Nws lub npe tshuaj tag nrho yog 6S-L-5-methyltetrahydrofolate, qhov twg L configuration sib haum mus rau chiral 6S configuration. Nws yog cov tshuaj lom neeg lom neeg isomer uas tuaj yeem nqus tau ncaj qha thiab siv los ntawm tib neeg lub cev yam tsis muaj kev hloov pauv metabolic hauv lub siab. Hauv kev sib txuas lus niaj hnub ntawm cov tub lag luam thiab cov khoom lag luam raw khoom, methylfolate tshwj xeeb yog hais txog cov tshuaj lom neeg L-hom monomer, uas txawv ntawm lub cev tsis muaj zog D-hom racemate thiab cov tsis muaj zog hluavtaws folic acid. Ob lo lus tsuas yog kev hloov pauv ntawm lub npe luv thiab lub npe tag nrho, thiab lawv xa mus rau tib yam khoom muaj nqis.
Cim npe nrov: l-5-mthf-ca l methylfolate calcium hmoov, Tuam Tshoj l-5-mthf-ca l methylfolate calcium hmoov manufacturers, lwm tus neeg, Hoobkas
