Dihydromyricetin hmoov

Dihydromyricetin hmoov(DHM los yog DMY) yog ib qho extract ntawm vine tshuaj yej, ib tug txiv hmab txiv ntoo.Nws muaj ntau yam kev ua haujlwm lom, nrog rau kev tshem tawm cov dawb radicals hauv lub cev, tiv thaiv -oxidation, tiv thaiv- mob ntshav siab, tiv thaiv- thrombus, tiv thaiv- qog, tiv thaiv - mob thiab lwm yam teebmeem tshwj xeeb.

Kintaiyog lub chaw tsim khoom loj ntawm dihydromyricetin, feem ntau ua98% thiab 30% dej -soluble dihydromyricetin(lwm yam specifications yuav customized). Lub Hoobkas ncaj qha tsim thiab ua lag luam, nrog tus nqi pheej yig, thiab GMP, ISO, HALAL, HACCP thiab lwm yam ntawv pov thawj. Los ntawm kev txiav -ntug extraction thiab purification cov txheej txheem, peb muab tshuaj- cov khoom qib, tswj dihydromyricetin nyob rau hauv nws cov dej bioactive tshaj plaws -soluble lub xeev. Qhov no ua kom pom kev nqus thiab ua haujlwm tau zoo thoob plaws ntau yam kev siv. Peb cov kev tswj xyuas nruj nruj tau lees paub qhov sib xws hauv purity thiab potency, ua rau peb cov Dihydromyricetin hmoov yog ib qho kev xaiv zoo rau kev lag luam nrhiav siab - cov khoom xyaw ntuj zoo. Txawm hais tias siv rau hauv cov dej haus, cov khoom noj khoom haus, tshuaj, lossis kev tu tawv nqaij, peb cov khoom zoo tshaj dej solubility thiab bioavailability txhawb kev txhim kho ntawm sab saum toj -tier formulations.Yog tias koj xav tau kev txiav txim, thov koj xav tias dawb rautiv tauj pebntawminfo@kintaibio.com.

High Potency & Clinical Efficacy
Kintai's Dihydromyricetin (CAS: 27200-12-}0) muab tshuaj-qib purity (Ntau dua lossis sib npaug li 98% los ntawm HPLC), txhim kho nrog dej-soluble thev naus laus zis rau kev pom zoo bioavailability. Clinically validated rau:

• Muaj zog hepatoprotection (ALP / AST txo los ntawm ntau dua lossis sib npaug li 35% hauv kev tshawb fawb ua ntej).
• Kev txhawb nqa plawv los ntawm cov txheej txheem antioxidant (ORAC tus nqi Ntau dua lossis sib npaug ntawm 5,000 μmol TE / g).
• Cawv metabolism acceleration (acetaldehyde clearance ↑200% vs. placebo).
• 500% solubility ntau dua li tus qauv dihydromyricetin (Ntau dua lossis sib npaug li 50g / L hauv dej).

Ntau-Kev Lag Luam Kev Lag Luam

• Cov Khoom Noj Uas Muaj Cov Khoom Noj: Cov tshuaj kho mob hangover (200–500mg / capsule) thiab cov dej haus rau lub siab (0.2–1g / L).
• Pharmaceuticals: Cov tshuaj hauv qhov ncauj rau kev tiv thaiv daim siab (300–600mg / hnub) thiab tshuaj tiv thaiv - cov tshuaj pleev xim (1–3%).
• Dej haus: Tsis yog- dej cawv detox (0.5–1.5g/L) thiab txhaj tshuaj tiv thaiv kab mob.
• Tshuaj pleev ib ce: Anti-cov tshuaj tiv thaiv kev laus (1–5%) thiab UV- cov tshuaj tiv thaiv.

Kev Tswj Xyuas Zoo

• Purity Assurance: HPLC- txheeb xyuas ntau dua lossis sib npaug li 98% purity, nrog cov hlau hnyav (Pb Tsawg dua lossis sib npaug rau 1ppm, Tsawg dua lossis sib npaug li 0.5ppm) thiab cov txwv microbial (Less dua lossis sib npaug rau 100CFU / g).
• Kev ruaj ntseg: Dej-soluble crystalline daim ntawv ruaj khov rau 36 lub hlis (25℃/ 60% RH).
• Kev Ua Raws Cai: Ua nyob rau hauv FDA- sau npe, GMP- cov chaw muaj ntawv pov thawj nrog ISO 22000 / HACCP ua raws.

Spec. & Daim ntawv xeem

 

Specification ntawm DHM

 

HPLC REPORT

Thib peb-cov ntaub ntawv xeem tog rau DHM hnyav hlau

Mycotoxins test report los ntawm PONY-98% DHM

Qhov siab tshaj plaws solubility yog: 335ml dej tuaj yeem yaj 500mgDHMnyob rau hauv 60-70 degree. Nws muaj zoo solubility nyob rau hauv dej kub, yuav luag tag nrho yaj ntawm 75 degree, thiab tsis muaj crystals precipitate tawm thaum kub poob mus rau chav tsev kub.

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I. Raw Material Selection thiab Pretreatment

Raw Material Sourcing

Peb siv cov nplooj me me ntawm Ampelopsis grossedentata (vine tshuaj yej) khaws ib ncig ntawm Qingming Festival. Cov nplooj me no muaj 20-30% DMY ntau dua piv rau cov nplooj paub tab. Tag nrho cov ntaub ntawv raw tau raug soj ntsuam nruj rau cov tshuaj tua kab thiab cov hlau hnyav, kom ua tau raws li Suav Pharmacopoeia cov qauv.

Txheej txheem Pretreatment

Kev ziab sai: Cov nplooj qhuav qhuav ntawm 60℃siv cua kub ncig kom txog thaum cov ntsiab lus noo noo qis dua 8%, khaws cov khoom xyaw nquag.

Sib tsoo thiab tshuaj ntsuam: Cov nplooj qhuav yog av thiab tshuaj xyuas los ntawm 40-mesh sieve. Qhov no ua rau cov cheeb tsam saum npoo, txhim kho cov txiaj ntsig extraction.

II. Core Extraction Technologies

Microwave -Ethanol Synergistic Extraction (Cov txheej txheem Patented)

Qhov hnyav piv: Peb siv 60% zaub mov-qib ethanol tov nrog cov khoom sib xyaw- kua piv ntawm 1:15 (g / mL).

Microwave Pab: Ntawm 500W lub zog, 50 feeb ntawm hluav taws xob, thiab 60 degree, cov nqi rho tawm ntau dua 90%.

Kev txuag hluav taws xob: Ib qho kaw - lub voj voog condensation rov ua dua ethanol, txo qhov poob qis dua 5%.

Optimized Dej Extraction (Tsawg-Kev Xaiv Tus Nqi)

Kev rho tawm dej ntshiab: Siv 1:20 khoom- kua piv, boiling ntawm 80℃rau 2 teev ua tiav 85% rho tawm tus nqi.

Dynamic Countercurrent Extraction: Peb-theem tandem extraction tso tsheb hlau luam txo cov kev siv hnyav los ntawm 30%.

III. Purification thiab Refinement

Kev Ua Haujlwm Tseem Ceeb

Vacuum Concentration: Extracts yog concentrated ntawm 40℃nyob rau hauv lub tshuab nqus tsev vacuum. Cov dej khib nyiab nrog BOD<100 enters our treatment system.

pH Precipitation: Ntxiv dej txias (pH{0}}) precipitates impurities, ua raws li decolorization nrog activated carbon.

Advanced Purification

Macroporous Resin Chromatography: AB-8 resin nrog ethanol gradient elution boosts purity mus rau 95%.

Tsawg-Tub kub Recrystallization: Ob lub voj voog recrystallization hauv 4: 1 ethanol-cov khoom siv dej tawm los nrog Ntau dua lossis sib npaug rau 98% purity thiab 75% rov qab.

IV. Quality Control thiab Innovation

Kev soj ntsuam online

HPLC tsis tu ncua saib xyuas DMY cov ntsiab lus, kom ntseeg tau cov khoom sib xws (RSD<2%).

Derivative Product Development

Esterification: Reacting DMY nrog linoleic acid tsim DMY linoleate, txhim kho lipid solubility thiab antioxidant zog.

Dej- Cov Qauv Tsim Kho: Kev sib xyaw nrog PVP K30 ua rau DMY dej- soluble, nthuav dav siv hauv tshuaj pleev ib ce.

Kev mob yog lub cev tiv thaiv hauv zos teb rau cov ntaub so ntswg raug mob, lub luag haujlwm tseem ceeb rau kev tswj hwm homeostasis thiab ib qho kev tshwm sim ntawm ntau yam kab mob. Kev mob tshwm sim tuaj yeem ua rau lub cev tsis muaj zog thiab cov ntaub so ntswg puas, xws li Alzheimer's kab mob, rheumatoid mob caj dab, thiab mob qog noj ntshav. Cov kev tshawb fawb tau pom tias LPS tuaj yeem txhawb cov lus teb rau RAW264.7 hlwb thiab nas, thiab DMY tuaj yeem cuam tshuam qhov kev qhia ntawm cov proteins koom nrog hauv TLR4/NF-κB taw qhia txoj hauv kev hauv LPS-induced microglial thiab cardiomyocyte raug mob.

Tsis tas li ntawd, DMY txhawb nqa phosphorylation ntawm IκB, yog li inhibiting NF-κB txoj kev taw qhia. DMY tseem tuaj yeem siv tshuaj kho mob ntawm qhov mob hauv vivo los ntawm inhibiting qhov ua kom NLRP3 inflammasome. Los ntawm kev kawm txog kev tiv thaiv kev tiv thaiv ntawm DMY ntawm LPS-induced inflammatory kev puas tsuaj ntawm lub cellular theem thiab nyob rau hauv nas, nws tau pom tias DMY muaj ib tug alleviating nyhuv ntawm LPS-induced o nyob rau hauv nas, thiab nws mechanism ntawm kev txiav txim tej zaum yuav muaj feem xyuam rau lub activation ntawm lub JAK1 / STAT3 signaling pathway, lub inhibition ntawm Thregistration 7 thiab lwm yam inflammatory axis.

(Siv: Kev tshawb fawb txog kev tiv thaiv ntawm dihydromyricetin ntawm LPS- ua rau muaj kev puas tsuaj rau cov nas)

1.Antioxidant:Nrog rau qhov nce ntawm purity ntawm dihydromyricetin, cov nyhuv antioxidant yog txhim kho, uas tuaj yeem tshem tawm cov dawb radicals hauv lub cev, txo qhov kev puas tsuaj los ntawm cov dawb radicals rau cov hlwb thiab cov ntaub so ntswg, yog li ncua cov txheej txheem kev laus, thiab muaj zog antioxidant nyhuv ntawm cov roj tsiaj thiab zaub roj.

2. Tiv thaiv daim siab:Dihydromyricetin tuaj yeem txhawb qhov kev puas tsuaj ntawm ethanol metabolites, ua lub luag haujlwm tiv thaiv kev haus dej cawv thiab haus cawv, txo cawv ua rau lub siab, txhim kho daim siab cell puas, inhibit daim siab cell deterioration, thiab ua lub luag haujlwm tiv thaiv daim siab.

3.Antibacterial nyhuv:Cov kev sim tau pom tias dihydromyricetin muaj cov kab mob tua kab mob ntawm Bacillus subtilis, Staphylococcus aureus, salmonella thiab lwm yam kab mob, thiab cov tshuaj tua kab mob muaj zog tshaj plaws hauv pH3 ~ 4 ib puag ncig, tab sis cov nyhuv inhibitory ntawm fungi tsis pom tseeb.

4. Cov teebmeem Antitumor:Cov kev tshawb fawb tau pom tias dihydromycetin muaj peev xwm los txhim kho qog noj ntshav thiab txhim kho cov tsos mob tseem ceeb ntawm tus neeg mob los ntawm inhibiting qog angiogenesis thiab modulating thiab txhim kho kev tiv thaiv kab mob ntawm tes. Hauv kev sim cov kev tshawb fawb ntawm cov qog ua qauv xws li leukemia thiab nasopharyngeal carcinoma, nws tau qhia pom tseeb los tiv thaiv- qog ua haujlwm, uas muab lub tswv yim tshiab thiab kev cia siab rau kev kho mob qog.

Tam sim no, dihydromyricetin feem ntau yog siv los ua cov khoom kho mob, tab sis kuj tseem tuaj yeem siv rau hauv kev kho mob ntawm cov kab mob ua pa, haus dej cawv ntawm Suav patent tshuaj npaj, xws li ntsiav tshuaj, tshuaj ntsiav, thiab granules.

1. Cov dej haus thiab cov khoom siv ntxiv

Vim nws lub siab - tiv thaiv thiab tiv thaiv -hangover zog,Dihydromyricetin hmoovyog ib qho khoom siv nrov hauv cov dej haus ua haujlwm. Nws tuaj yeem muab ntxiv rau cov dej haus ntawm qhov siab ntawm 0.2 - 1g / L, muab cov neeg siv khoom yooj yim los tiv thaiv lawv daim siab tom qab haus cawv. Hauv kev noj zaub mov noj, nws feem ntau yog tsim rau hauv cov tshuaj ntsiav lossis ntsiav tshuaj, nrog rau qhov ntau npaum li cas ntawm 200 - 500mg ib qho kev pabcuam, tsom mus rau kev noj qab haus huv-cov tib neeg uas paub qab hau nrhiav kev txhim kho lawv lub siab tag nrho thiab kev noj qab haus huv hauv metabolic.

2. Kev lag luam kws tshuaj

Hauv kev lag luam tshuaj, DHM qhia tau zoo heev. Nws cov tshuaj tiv thaiv antioxidant thiab tiv thaiv - los tiv thaiv - cov teebmeem inflammatory ua rau nws muaj txiaj ntsig zoo hauv cov tshuaj kho mob siab. Nws tuaj yeem tsim kho rau hauv cov qauv hauv qhov ncauj, nrog rau kev noj txhua hnub ntawm 300 - 600mg, los pab kho lub siab hlwb thiab txhim kho daim siab ua haujlwm. Tsis tas li ntawd, nws cov khoom tiv thaiv neuroprotective tuaj yeem pab txhawb kev tsim cov tshuaj rau cov kab mob neurodegenerative, txawm hais tias kev tshawb fawb ntxiv tseem tab tom ua.

3. Cosmetics Field

Lub peev xwm antioxidant zoo heev ntawm Dihydromyricetin ua rau nws tawm tsam dawb radicals, ua rau nws tsim nyog rau kev tiv thaiv kev laus - cov tshuaj pleev ib ce. Nws tuaj yeem muab ntxiv rau cov tshuaj pleev ib ce, tshuaj pleev, thiab tshuaj pleev xim ntawm qhov ntau ntawm 1 - 5%. Nws pab txo cov tsos ntawm wrinkles, txhim kho daim tawv nqaij kev ntxhib los mos, thiab tiv thaiv daim tawv nqaij los ntawm ib puag ncig puas. Tsis tas li ntawd, nws cov khoom siv los tiv thaiv - kuj tuaj yeem muaj txiaj ntsig zoo rau cov khoom tu tawv nqaij rhiab, soothing tawv nqaij thiab txo qhov liab.

4. Kev lag luam zaub mov ua Antioxidant

Raws li lub ntuj antioxidant, DHM tuaj yeem siv rau hauv kev lag luam zaub mov kom ntev lub neej ntawm cov khoom noj khoom haus. Nws tuaj yeem muab ntxiv rau cov roj noj, cov nqaij ua tiav, thiab khoom noj txom ncauj. Piv txwv li, hauv cov roj noj, ntxiv me me (0.01 - 0.05%) tuaj yeem tiv thaiv lipid oxidation zoo, tswj qhov zoo thiab tsw ntawm cov roj, thaum tseem muab cov txiaj ntsig kev noj qab haus huv ntxiv rau cov neeg siv khoom.

5. Tsiaj Pub Ntxiv

Hauv kev ua liaj ua teb, Dihydromyricetin tuaj yeem siv los ua khoom noj rau tsiaj txhu. Nrog rau qib ntxiv ntawm 10 - 20mg / kg hauv cov tsiaj pub, nws tuaj yeem txhim kho cov tsiaj tiv thaiv kab mob, txhim kho lawv txoj kev loj hlob, thiab txo qhov tshwm sim ntawm cov kab mob. Qhov no tsis yog tsuas yog pab tsiaj noj qab haus huv xwb tab sis kuj muaj kev cuam tshuam zoo rau qhov zoo thiab kev nyab xeeb ntawm tsiaj- cov khoom tau los.

Toxicological kev txiav txim siab

KINTAI's Dihydromyricetin Powder ua rau pom kev mob toxicity tsawg. Cov kev tshawb fawb tsiaj tau qhia tias qhov ncauj LD₅₀ tus nqi siab tshaj 2000 mg / kg, qhia tias muaj kev pheej hmoo tsis zoo ntawm kev mob hnyav ntawm kev siv ib txwm. Tsis muaj qhov cuam tshuam loj heev tau raug tshaj tawm hauv tib neeg daim ntawv thov nyob rau hauv qhov pom zoo ntau npaum li cas. Txawm hais tias kev kis tus kab mob mus ntev yog suav hais tias feem ntau muaj kev nyab xeeb, kev noj zaub mov tsis zoo yuav ua rau muaj cov tsos mob me xws li plab zom mov lossis xeev siab hauv qee tus neeg mob. Txhawm rau tiv thaiv cov neeg siv khoom zoo -, KINTAI tsis tu ncua ua cov tshuaj toxicity tag nrho, ua kom muaj kev ua raws li cov cai tswj kev nyab xeeb.

Kev Tswj Xyuas Zoo & Kev Nyab Xeeb Kev Nyab Xeeb

Tsim nyob rau hauv cov chaw uas ua tau raws li Kev Tswj Xyuas Zoo (GMP) cov qauv, KINTAI's DMY tsis tu ncua tswj cov qib purity ntawm ntau dua lossis sib npaug li 98%, raws li kev txheeb xyuas tseeb los ntawm High - Performance Liquid Chromatography (HPLC). Txhua batch raug soj ntsuam nruj me ntsis rau cov hlau hnyav, nrog rau kev txwv ntawm Pb Tsawg dua lossis sib npaug rau 2ppm thiab Raws li Tsawg dua lossis sib npaug rau 1ppm. Tsis tas li ntawd, cov kuab tshuaj residual thiab microbial kev nyab xeeb raug tshuaj xyuas nruj. Daim Ntawv Pov Thawj Paub Txog Kev Ntsuam Xyuas (COA) thiab Cov Ntaub Ntawv Kev Nyab Xeeb Cov Ntaub Ntawv (MSDS) tau muab rau txhua pawg, lees paub ua raws li kev nyab xeeb thoob ntiaj teb cov qauv tsim los ntawm FDA, EFSA, thiab WHO.

Kev ceeb toom kev nyab xeeb & txwv

Contraindications:Vim cov ntaub ntawv kev nyab xeeb tsis txaus, Dihydromyricetin Powder tsis pom zoo rau cov poj niam cev xeeb tub lossis lactating yam tsis muaj kev sib tham ua ntej.

Kev tsis pom zoo:Kev noj ntau dhau yuav ua rau mob plab me ntsis. Yog hais tias muaj kev tsis xis nyob los yog tshwm sim tsis zoo tshwm sim, tam sim ntawd txiav kev siv tam sim ntawd.

Kev tuav:Txhawm rau kom tsis txhob muaj qhov ua pa ua pa, kev nqus tau ncaj qha ntawm cov hmoov yuav tsum raug zam kom nruj. Nws raug nquahu kom tuav cov hmoov hauv qhov dej zoo - qhov cua. Khaws cov khoom hauv qhov chaw txias, qhuav, tiv thaiv los ntawm tshav ntuj ncaj qha kom tswj tau nws qhov zoo thiab ruaj khov.

1. Peb cog lus tias peb cov ntaub ntawv raw yog ib txwm loj hlob tsis muaj additives.
2. Peb muab cov kev daws teeb meem tshwj xeeb los tsim Dihydromyricetin.
3. Peb cov chaw tsim khoom tuav cov ntawv pov thawj thoob ntiaj teb suav nrog GMP, ISO 9001, ISO 22000, HACCP, thiab HALAL.

Yog tias koj txaus siab, thov koj xav tias dawb rau tiv tauj pebntawminfo@kintaibio.com.

Cim npe nrov: Tuam Tshoj dihydromyricetin hmoov manufacturers, lwm tus neeg, Hoobkas