Podophyllum Resin Podophyllin hmoov

Noj qab haus huv^®yog achaw tsim tshuaj paus thiab tsum ntawm podophyllum resin. Podophyllum resin yog ib qho kev sib xyaw ua ke ntawm cov rhizome ntawm Himalayan podophyllum (Podophyllum hexandrum). Nws zoo li lub teeb xim av mus rau ntsuab - cov pob daj lossis amorphous hmoov. Lub ntsiab active ingredient ntawm no resin yog podophyllotoxin.Podophyllinmuaj zog cytotoxic teebmeem; Nws cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog cov khoom xyaw nquag khi rau tubulin, thaiv cov cell mitosis, thiab yog li inhibiting cell proliferation. Raws li cov cuab yeej tshuaj no, podophyllum resin feem ntau yog siv kho mob rau kev kho mob ntawm daim tawv nqaij xws li condyloma acuminata thiab verruca vulgaris. Nws kuj yog ib qho tseem ceeb pib cov khoom siv rau semi-synthetic antitumor tshuaj etoposide thiab teniposide. Raulag luam wholesale podophyllum resin hmoov, tiv tauj pebntawminfo@kintaibio.com.

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Raw Material Processing thiab Percolation Extraction

Cov rhizomes ntawmPolypodiumCov tsiaj yog pulverized rau hauv 60-mesh hmoov thiab muab tso rau hauv ib qho percolation chamber.Cov hmoovyog moistened nrog ib tug tsim nyog tus nqi ntawm ethanol (kwv yees li 480 mL ib 1000 g ntawm raw khoom) thiab kom meej compacted. Ethanol yog ntxiv kom txog thaum cov hmoov txheej yog tag nrho, thiab lub chamber raug kaw thiab tsau rau 48 teev. Tom qab ntawd, ethanol yog ntxiv rau ntxiv percolation extraction, sau kwv yees li 1600 mL ntawm percolate, los yog kom txog thaum lub percolate tsim me ntsis turbidity thaum poob rau hauv dej. Cov kauj ruam no siv ethanol los ua cov kuab tshuaj kom yaj cov resinous Cheebtsam hauv cov nroj tsuag hlwb.

Nco ntsoov

Cov percolate tau muab tso rau hauv ib da dej da dej thiab distilled kom rov qab tau cov ethanol, tsom mus rau hauv ib lub syrupy, tuab kua. Qhov ntsuas kub yuav tsum tau tswj nyob rau hauv qhov qis qis (tsis pub tshaj 80-85℃F / kwv yees li 29 degree) txhawm rau tiv thaiv qhov kub thiab txias los ntawm kev ua kom cov resin darken xim los yog ua kom puas cov khoom xyaw.

Dej nag

Thaum tsis tu ncua stirring, maj mam ncuav cov concentrated kua rau hauv ua ntej - txias acidic dej (10 mL ntawm hydrochloric acid rau txhua 1000 g ntawm raw khoom, 10 mL dej). Txij li thaum podophyllum resin yog insoluble hauv dej thaum lwm cov dej -soluble impurities yog soluble, cov resin yuav precipitate. Tom qab tso cai rau lub precipitate kom daws tau tag nrho, muab pov tseg lub supernatant thiab ntxuav lub precipitate ob zaug nrog tshiab, dej txias kom tshem tawm cov residual acid thiab colloids.

Qhuav

Tshaj tawm cov dej ntub dej ntawm cov ntaub lim dej thiab cua qhuav hauv qhov chaw txias, qhov cua (xws li thaum lub caij txias). Yog hais tias cov resin clumps los yog tsim ib tug lacquer -zoo li lub plhaub tawv thaum lub sij hawm ziab, tawg nws thiab zom rau hauv ib lub mortar. Cov qhuav podophyllum resin yog lub teeb xim av mus rau yellowish -ntsuab hmoov; cov tsoos yield yog kwv yees li 3-6% ntawm raw khoom hnyav.

Lub ntsiab active ingredient nyob rau hauvpodophyllotoxin cob, podophyllotoxin, inhibits lub polymerization ntawm tubulin dimers los ntawm tshwj xeeb khi rau colchicine binding site ntawm cellular tubulin, yog li thaiv kev tsim ntawm spindle microtubules thiab ntes cell mitosis ntawm theem G2 / M. Qhov kev cuam tshuam tsis zoo ntawm kev faib tawm ntawm tes no nyiam cuam tshuam rau cov ntaub so ntswg, xws li keratinocytes thiab qog hlwb, tab sis tsis tshua muaj txiaj ntsig rau cov hlwb quiescent. Tsis tas li ntawd,podophyllotoxin hmoovthiab nws cov semi-synthetic derivatives, xws li etoposide, tuaj yeem ua rau DNA topoisomerase II- kho DNA strand so, ntxiv rau txoj kev apoptosis.

Qhov no dual mechanism microtubule cuam tshuam tom qab DNA kev puas tsuaj nyiaj rau lub zog antimitotic thiab antineoplastic zog ntawm podophyllotoxin derivatives. Yog li ntawd, thaum crudepodophyllotoxin cobtsuas yog siv cov tshuaj pleev ib ce vim muaj kev pheej hmoo toxicity, nws cov purified derivatives tau dhau los ua cov tshuaj chemotherapeutic hauv kev kho cov cell me.

Podophyllin thiab imiquimodyog ob qho tib si siv tshuaj pleev xim rau kev kho mob condyloma acuminata, tab sis lawvmechanisms ntawm kev uathiab kev siv tshuaj kho mob txawv heev. Lub ntsiab feem ntawmpodophyllin, podophyllotoxin, inhibits microtubule polymerization, thaiv cov kab mob mitosis ntawm HPV-cov kab mob epithelial, ua rau necrosis thiab shedding.Imiquimod, ntawm qhov tod tes, yog ib qho me me - molecule immunomodulator uas ua rau lub cev tiv thaiv kab mob kom tshem tau tus kab mob, tsis muaj kev cuam tshuam cytotoxic. Hais txog kev ua tau zoo, cov kev tshawb fawb qhia tau hais tias qhov kev tshem tawm zoo sib xws uas tsis muaj qhov sib txawv tseem ceeb, tab sis imiquimod muaj qhov pib qeeb qeeb, nrog rau lub sijhawm nruab nrab ntawm 8-12 lub lis piam, thaum cov tshuaj podophyllin feem ntau siv tau li ntawm 2-3 lub lis piam.

Hais txog kev nyab xeeb,imiquimodmuaj cov tshuaj tiv thaiv hauv zos me duapodophyllin, xws li kub hnyiab thiab mob, thiab tuaj yeem siv rau cov kab mob loj dua vim nws tsis ua rau cov ntaub so ntswg puas. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias podophyllin muaj qhov tseeb teratogenicity thiab tuaj yeem nqus tau los ntawm daim tawv nqaij, ua rau muaj kab mob toxicity; Yog li ntawd, nws yog nruj me ntsis contraindicated nyob rau hauv cov poj niam cev xeeb tub thiab daim ntawv thov cheeb tsam yuav tsum nruj me ntsis tswj.

Podophyllin thiab podophyllotoxintxawv qhov txawv ntawm qhov, muaj pes tsawg leeg, kev ua tau zoo, thiab kev nyab xeeb. Lub qub yog sib tov, thaum lub tom kawg yog ib qho purified ib qho active ingredient.Podophyllinyog ib tug resinous crude extract los ntawm rhizomes ntawm cov nroj tsuag nyob rau hauv lubPodophyllum genus. Nws muaj ib tug complex muaj pes tsawg leeg, muaj podophyllotoxin, flavonoids, thiab lwm yam tshuaj. Cov ntsiab lus ntawm cov khoom xyaw nquag, podophyllotoxin, feem ntau tsuas yog 20% ​​-40%, thiab nws txawv nyob ntawm qhov chaw cog thiab batch.Cov tshuaj Podophyllotoxin, ntawm qhov tod tes, yog crystalline compound purified los ntawm resin siv cov txheej txheem kev sib cais niaj hnub, ua tiav qhov purity ntawm ntau dua 90%. Nws yog ib feem nrog kev tswj tau zoo.

podophyllin rau warts

Lub ntsiab kev ua tau zoo ntawmpodophyllin nyob rau hauv kev kho mob warts(tshwj xeeb tshaj yog condyloma acuminata) nyob hauv nws cov khoom xyaw nquag,podophyllotoxin, uas inhibits microtubule polymerization, thaiv mitosis hauv HPV-cov kab mob epidermal, ua rau lawv ntes tau nyob rau theem G2 / M thiab thaum kawg necrose thiab slough tawm. Hauv kev siv tshuaj kho mob, 10% -25% concentration ntawm podophyllin tincture los yog tshuaj feem ntau yog siv rau thaj tsam me me ntawm cov kab mob sib kis los ntawm tus kws kho mob, zam kev sib cuag nrog cov tawv nqaij noj qab nyob zoo. Cov tshuaj no zoo heev rau cov mos mos, uas tsis yog-keratinized condyloma acuminata; Cov txheej txheem kev kho mob feem ntau suav nrog daim ntawv thov 1-2 zaug hauv ib lub lis piam rau 3-6 lub lis piam, ua tiav qhov txhab tshem tawm ntawm 40% -80%.

podophyllin rau daim tawv nqaij tag

Hais txog kev ua tau zoo ntawm podophyllin rau daim tawv nqaij tag, nws daim ntawv thov yog feem ntau raws li kev siv empirical. Qee cov ntaub ntawv kho mob teev nws ua ib qho tshuaj uas tuaj yeem siv los kho daim tawv nqaij. Nws cov txheej txheem ntawm kev ua haujlwm yog nyob rau hauv nws cov nyhuv antimitotic, uas tso cai rau nws khi rau tubulin thiab inhibit microtubule tsim, yog li cuam tshuam cov cell proliferating sai. Txawm li cas los xij,daim tawv nqaij tagyog benign qog tsim los ntawm collagen fibers thiab xoob connective cov ntaub so ntswg, thiab lawv cov cell proliferation kev ua nyob deb tsawg tshaj li cov kab mob warts xws li condylomata acuminata. Yog li ntawd, theoretical therapeutic effect yog txwv. Tam sim no, cov ntaub ntawv qhia rau podophyllin hauv dermatology tsuas yog siv rau kev kho mob ntawm condylomata acuminata, ib hom kab mob ntawm qhov chaw mos.

podophyllin tshuaj pleev / podophyllin cream

Daim ntawv thov ntawmpodophyllotoxin resin nyob rau hauv cream los yog tshuaj pleevLub hom phiaj tseem ceeb yog xa cov khoom muaj txiaj ntsig mus rau thaj chaw cuam tshuam los ntawm kev muab cov khoom sib xws thiab yooj yim kis tau. Nyob rau tib lub sijhawm, lub semi- cov khoom tsim tawm cov nyhuv occlusive nce stratum corneum hydration, yog li txhawb kev nkag mus rau cov tshuaj hauv zos. Podophyllotoxin ointment yog suav nrog hauv Tuam Tshoj txoj kev pov hwm kho mob raws li thawj - kab tshuaj pleev xim rau kev kho mob ntawm qhov chaw mos. Cov tshuaj podophyllotoxin cream formulation yog purer, tso cai rau cov neeg mob ua tus kheej - noj tshuaj nyob hauv tsev rau kev kho mob tsawg, thiab nws qhov kev khaus khaus hauv zos thiab cov kev pheej hmoo ntawm kev nqus tau qis dua li cov tshuaj crude resin formulations.

Podophyllum resin serums

Daim ntawv thov tseem ceeb ntawm Podophyllum resin serums formulations nyob rau hauv nws siv raws li ib tug keratolytic neeg sawv cev rau cov tshuaj pleev ib ce ntawm ntau yam warts, tshwj xeeb tshaj yog condyloma acuminata. Ib tus neeg sawv cev muag khoom muag yog "PODOFILM," ib qho 25% concentration ntawm podophyllum cag resin tov, uas yog xim av - kua liab. Nws daim ntawv thov kev kho mob tag nrho embodies cov yam ntxwv ntawm Podophyllum resin serums formulations: los ntawm meej daim ntawv thov hauv zos, cytotoxic thiab antimitotic teebmeem ntawm podophyllum resin ncaj qha rhuav tshem thiab tshem tawm cov warts.

Raws li cov ntaub ntawv khoom lag luam thiab cov ntaub ntawv pov thawj kev kho mob, raws li tau teev tseg hauv DailyMed database hauv qabNational Institutes of Health (NIH), tus qauv formulation ntawmpodophyllinyog 25% kev daws teeb meem, thiab nws yuav tsum tau thov los ntawm tus kws kho mob hauv chav kuaj. Cov neeg mob raug txwv tsis pub siv nws tus kheej. Tshwj xeeb, tus kws kho mob yuav tsum ua ntej ntxuav qhov chaw cuam tshuam, tom qab ntawd siv tus neeg thov tshwj xeeb los siv cov txheej nyias nyias ntawm cov tshuaj rau saum npoo ntawm cov pob tw, saib xyuas kom tsis txhob muaj kev sib cuag nrog cov ntaub so ntswg noj qab haus huv.

Thaum lubkev nyab xeeb ntawm podophyllotoxin resinyog tswj tau raws li kev thov kom raug, kev siv tsis raug tuaj yeem ua rau muaj qhov tshwm sim loj. Cov kev pheej hmoo tseem ceeb nyob hauv lub zog cytotoxicity ntawm nws cov khoom xyaw nquag,podophyllotoxin, tshwj xeeb tshaj yog thaum siv rau thaj chaw loj rau lub sijhawm ntev lossis ua rau cov hlab ntsha tawg lossis los ntshav. Kev lom neeg feem ntau tshwm sim ob peb teev tom qab siv, nrog cov tsos mob thaum ntxov xws li xeev siab, ntuav, mob plab, thiab raws plab. Lub paj hlwb yog qhov yooj yim tshaj plaws, muaj peev xwm txhim kho mus rau axonal sensorimotor neuropathy, manifesting li loog loog, tingling, thiab tsis muaj zog ntawm tes thiab ko taw. Hauv cov xwm txheej hnyav, kev hnov ​​​​mob ataxia, poob ntawm tendon reflexes, thiab txawm tias lub cev tsis muaj zog tuaj yeem tshwm sim.

Peb pom zoo heevNoj qab haus huv^® podophyllin cob. Cov khoom no siv ua tib zoo xaiv cov ntaub ntawv raw thiab cov txheej txheem rho tawm los ua kom cov ntsiab lus podophyllotoxin ruaj khov hauv txhua pawg, lav qhov siab purity thiab sib xws ntawm cov khoom siv. Peb lub tuam txhab nruj me ntsis ua raws li ISO thiab GMP kev tswj hwm kev tswj hwm zoo thiab muab Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (COA) cov ntaub ntawv ua tiav, kom ntseeg tau tias cov hlau hnyav, hnyav residues, thiab cov ntsuas microbiological tag nrho raws li cov qauv tshuaj pharmacopoeia thoob ntiaj teb. Xaiv peb yuav muab kev txhawb nqa kev tshaj lij rau koj, kev pabcuam hloov kho tau yooj yim, thiab tus nqi sib tw.Tiv tauj pebntawminfo@kintaibio.com.

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