Mangiferin hmoov

Mangiferinyog ntuj C-glycoside flavonoid nyob rau tsev neeg xanthone.Mango nploojua tus thawj industrial extraction raw khoom. nplua nuj nyob rau hauv phenolic hydroxyl pawg, cov khoom xyaw nquag no muab cov dawb radical scavenging zoo heev thiab cov teebmeem antioxidant. Nws kuj muab dav -spectrumanti- mobthiabtshuaj tua kab mobcov txiaj ntsig. Tsis tas li ntawd, nws pab txo qis kev ua pa tsis zoo, txhawb lub siab kev noj qab haus huv, pab tswj cov tshuaj insulin rhiab heev, ua kom lub cev tsis muaj zog, txo cov kev mob ntawm daim tawv nqaij, thiab muaj kev noj qab haus huv me me ntawm lub paj hlwb.

Mangiferinmuaj mature industrial daim ntaub ntawv nyob rau hauv ntau yam teb.Hauv tshuaj, nws yog siv nyob rau hauv cov khoom easing bronchial tsis xis nyob thiab tshiab daim siab & metabolism regulating tshuaj tshawb fawb.Rau kev noj zaub mov ntxiv, nws ntxiv rau daim siab- tiv thaiv, antioxidant thiab ntshav qab zib- ntsuas cov hmoov thiab cov ntsiav tshuaj.Hauv tshuaj pleev ib ce, nws nta hauv kev thaiv- kho, ci ntsa iab, tom qab- tshav ntuj thiab tiv thaiv - kev laus ntawm daim tawv nqaij kom sov xim liab, suppress melanin thiab ntxiv dag zog rau daim tawv nqaij.

Nrog ntau tshaj kaum xyoo ntawm kev txawj ntse hauv botanical extracts,Noj qab haus huv^®tuav ywj pheej invention patents ntsig txog mangiferin. Peb muab cov hmoov mangiferin hauv ntau qhov tshwj xeeb, suav nrog 15% (dej-soluble), 60%, 95%,thiab98%qib, haum rau cov qauv hauv tshuaj, tshuaj noj thiab tshuaj pleev ib ce. Thov tiv tauj pebntawmhealth@kintaibio.comlos qhia koj cov kev cai tsim nrog peb rau kev sib tham txog kev koom tes ntxiv.

 

 

Mangiferinyog polyphenolic glycoside nrog nruab nrab tag nrho polarity. Nws solubility sib txawv heev nrog hnyav polarity thiab kub. Nyob rau hauv chav tsev kub, nws tsuas yog me ntsis soluble nyob rau hauv nruab nrab polar organic solvents, thiab nws solubility nce markedly thaum cua sov. Nws nthuav tawm qhov zoo tshaj plaws solubility nyob rau hauv DMSO, ib tug muaj zog polar aprotic hnyav, thiab ib tug ntshiab concentrated tov tau nrog kev pab los ntawm ultrasonication. Nws yog sparingly soluble nyob rau hauv methanol thiab ethanol, thaum nws dissolution yog zoo heev nyob rau hauv kub dilute methanol thiab kub dilute ethanol. Nws yog insoluble nyob rau hauv weakly polar thiab nonpolar organic solvents xws li diethyl ether, chloroform, roj av ether thiab n-hexane, thiab NW nyuam qhuav soluble nyob rau hauv acetone thiab ethyl acetate. Zuag qhia tag nrho, nws cov solubility ua raws li txoj cai uas cov kuab tshuaj ntau dua polarity thiab kub dua ua rau kev ua haujlwm zoo dua.

Mangiferin Solubility hauv dej

Mangiferin muaj dej solubility tsis zoo nyob rau hauv chav tsev kub. Nws saturated solubility nyob rau hauv cov dej ntshiab ntawm 25℃yog tsawg dua 0.1 mg / mL, ua rau nws xyaum insoluble nyob rau hauv dej txias. Nws solubility nce me ntsis nrog kub; Tsuas yog ib qho me me tuaj yeem yaj hauv cov dej kub npau npau lossis dej kub, thiab tsuas yog qis dua -cov ntsiab lus dilute cov ntsiab lus tuaj yeem npaj tau. High -cov ntsiab lus aqueous mangiferin tsis tuaj yeem tsim nrog dej ntshiab ib leeg.

Peb 15% dej -mangiferin solubleyog ua tiav los ntawm kev hloov kho thev naus laus zis tshwj xeeb, uas ua rau muaj txiaj ntsig zoo rau hydrophilicity ntawm cov khoom siv raw. Nws tuaj yeem tawg sai sai thiab yaj hauv dej huv ntawm chav tsev kub kom tsim tau cov kua ntshiab yam tsis muaj qhov pom tseeb precipitates. Tau tshaj txhua hom aqueous formula systems, nws tuaj yeem muab tso ncaj qha rau hauv cov kua hauv qhov ncauj, dej-raws li cov khoom tu tawv nqaij, kua dej haus, dej- cov hmoov soluble thiab lwm yam khoom tsis muaj ethanol ua solubilizer. Nws nta cov teeb meem kev siv qis dua thiab cov ntawv thov dav dua.

Teb chaws USA

Hauv Tebchaws Meskas, qis -puritymangiferin extractslos ntawm cov nplooj txiv nkhaus taw tuaj yeem nthuav tawm dawb li botanical dietary supplement raw cov ntaub ntawv, thiab cov tuam txhab lag luam tuaj yeem ua tiav nws tus kheej - lees paub GRAS cov ntaub ntawv siv rau hauv cov khoom noj khoom haus, cov khoom noj khoom haus kis las thiab cov ntsiav tshuaj. Txawm hais tias tsis muaj ntawv ceeb toom GRAS rau siab -purity mangiferin monomer, nws kuj tsim nyog rau tus kheej - lees paub GRAS txoj hauv kev. Tsis muaj kev cai lij choj txwv kev noj haus ntau tshaj plaws txhua hnub, thaum feem ntau lees txais kev lag luam nyab xeeb ntau npaum li cas ntawm mangiferin ntshiab tsis pub tshaj 500 mg ib hnub twg. Rau kev siv tshuaj pleev ib ce, nws yog ib qho ua tau raws li botanical active ingredient nrog antioxidant thiab soothing teebmeem. Los ntawm kev tswj xyuas tshuaj lom neeg, mangiferin tsis tau teev nyob rau hauv TSCA Inventory. Cov khoom me me - ntim khoom ntim khoom noj khoom haus thiab kev siv tshuaj pleev ib ce feem ntau raug zam los ntawm TSCA ceeb toom, thaum cov khoom lag luam feem ntau xav tau TSCA ua ntej - ceeb toom.

EU

Hauv EU, qis-cov ntsiab lus tsis txaus siab tau raug zam los ntawm EFSA Novel Food daim ntawv thov vim lawv qhov kev siv keeb kwm raws li tshuaj ntsuab tshuaj yej, thaum cov tshuaj purified mangiferin monomers yog qhov yuav tsum tau ua.Novel Foodkev pom zoo. Txoj cai tswj hwm qhov kev lees paub txhua hnub (ADI) ntawm mangiferin ntawm0.3mg ibib kilogram ntawm lub cev qhov hnyav, thiab cov khoom tiav yuav tsum tau sau nrog qhov siab tshaj plaws uas pom zoo. Rau kev siv tshuaj, CEP (Certificate of Suitability to the monographs of the European Pharmacopoeia) tuaj yeem siv rau, tab sis mangiferin tsuas yog siv hauv homeopathic thiab tshuaj ntsuab tshuaj ntsuab uas tsis muaj kev pom zoo tib neeg cov khoom siv tshuaj raws li monomer. Hauv cov tshuaj pleev ib ce, nws suav nrog hauv CosIng database yam tsis muaj kev txwv lossis txwv tsis pub muaj kev txwv. Chemically, mangiferin tsis muaj EINECS tus lej sau npe, thiab kev xa khoom me me ntawm cov khoom noj thiab cov khoom siv tshuaj pleev ib ce nrog cov khoom xa tawm txhua xyoo qis dua 1 tuj raug zam los ntawm REACH sau npe.

Mangiferin rau kev tswj ntshav qab zib

Mangiferintswjntshav qabzibhomeostasis nyob rau hauv lub cev los ntawm ntau yam synergistic mechanisms. Nws inhibits plab hnyuv -glucosidase kev ua haujlwm kom qeeb qhov kev tawg thiab nqus cov hmoov txhuv nplej siab thiab sucrose, txo qis cov ntshav qabzib hauv cov ntshav qabzib. Lub caij no, nws ua rau lub AMPK taw qhia txoj hauv kev hauv cov nqaij thiab cov nqaij adipose, txhawb kev qhia ntawm GLUT4 glucose transporters, thiab ua kom cov piam thaj nce ntxiv thiab cov metabolism hauv cov ntaub so ntswg peripheral. Tsis tas li ntawd, nws inhibits cov enzymes tseem ceeb koom nrog hauv siab gluconeogenesis kom txo qis cov piam thaj endogenous.

Tsis tas li ntawd, nws alleviates oxidative kev nyuaj siab puas tsuaj rau pancreatic -cells, txhim kho lub cev insulin rhiab heev thiab alleviates insulin tsis kam. Los ntawm peb txoj hauv kev- ua kom cov ntshav qabzib ua kom zoo dua qub, txiav cov piam thaj endogenous synthesis, thiab txhim kho cov tshuaj insulin zoo dua - nws pab txhawb cov ntshav qabzib kom ruaj khov.

Mangiferin rau daim siab

Mangiferinexerts hepatoprotective teebmeem los ntawm ntau yam mechanisms. Nws activates lub siab lub cevantioxidanttiv thaiv kab mob kom tshem tawm cov dawb radicals thiab txo oxidative puas tsuaj. Lub caij no, nws suppresses inflammatory signaling pathways kom txo tau cov theem ntawm pro- inflammatory yam tseem ceeb thiab txo cov mob hepatic o. Tsis tas li ntawd, cov khoom xyaw nquag no pab thaiv qhov kev loj hlob ntawm daim siab fibrosis thiab modulates lipid metabolism kom txo qis cov rog hauv siab.

Cov kev tshawb fawb thoob plaws ntau hom kev raug mob rau daim siab tau txheeb xyuas tias mangiferin tuaj yeem txo cov qib transaminase thiab txhim kho daim siab ua haujlwm. Thaum cov txiaj ntsig no tau muab los ntawm kev sim ntawm tes thiab tsiaj sim, mangiferin, raws li lub ntuj bioactive compound, qhia tau tias muaj peev xwm los txhawb lub siab noj qab haus huv.

Mangiferin rau Nerve thiab Cardiovascular Protection

Rau kev txhawb nqa paj hlwb, mangiferinupregulates cov kev ua ntawm PI3K / Akt / mTOR kev taw qhia txoj hauv kev thiab thaiv kev sib kis ntawm MCP-1 / CCR2 inflammatory pathway, alleviating cerebral oxidative stress thiab inflammatory teb thiab txo cov tsos mob ntawm neuronal apoptosis. Cov ntaub ntawv kev sim uas twb muaj lawm qhia tias cov khoom siv bioactive no pab txhim kho kev txawj ntse thiab muaj kev tiv thaiv kev tiv thaiv lub hlwb tsis xis nyob vim yog mob hlwb ischemia, hypoxia thiab ntshav siab.

Hais txog kev txhawb nqa plawv, mangiferinactivates Nrf2 txoj hauv kev los txhawb lub plawv lub cev tiv thaiv kab mob hauv lub plawv thaum tiv thaiv kev ua haujlwm ntawm cov kab mob inflammatory xws li NF-κB, txo cov ntaub so ntswg puas los ntawm myocardial ischemia-reperfusion thiab oxidative stress. Tsis tas li ntawd, nws pab kho cov vascular endothelial muaj nuj nqi, inhibits platelet aggregation txawv txav, thiab tswj cov lipid metabolism hauv lub cev kom xa tau ntau yam -kev txhawb nqa rau cov hlab plawv.

Mangiferin rau tawv nqaij

Nrog synergisticantioxidant, anti- mobthiab daim tawv nqaij barrier-cov khoom txhawb nqa,mangiferinpab tu tawv nqaij. Nws tshem tawm cov dawb radicals ntau dhau ntawm cov epidermis thiab dermis, alleviates lipid peroxidation tshwm sim los ntawm UV rays, thiab txhim kho kev laus kev txhawj xeeb xws li dullness thiab tsis sib xws ntawm daim tawv nqaij. Meanwhile, nws suppresses lub secretion ntawm ntau yam pro- inflammatory yam mob rau soothe rhiab tawv nqaij teeb meem nrog rau cov liab thiab khaus. Nws kuj tseem hloov kho txoj hauv kev uas cuam tshuam rau melanin ntau lawm kom maj mam ua kom cov xim pigmentation, txhawb cov synthesis ntawm cov protein ua haujlwm hauv stratum corneum kom ntxiv dag zog rau daim tawv nqaij barrier, thiab txo qis kev khaus tshwm sim los ntawm ib puag ncig ib puag ncig kev ntxhov siab, muab ntau yam -faceted kev txhawb nqa los tswj cov tawv nqaij, ruaj khov thiab noj qab nyob zoo.

Kev siv tshuaj Mangiferin

Pharmaceuticals sawv cev rau daim ntawv thov kev lag luam loj tshaj plaws raumangiferin, nrog downstream buyers feem ntau yog nrhiav tau siab -purity kws tshuaj- qib khoom ntawm95% thiab 98%. Mangiferin boasts ntau yam ntawm daim ntawv thov scenarios. Nws yog siv rau hauv kev cuam tshuam thiab kev kho mob ntawm cov kab mob ntev xws li mob ntsws bronchitis, kab mob siab ntev, rheumatoid o thiab metabolic syndrome. Nws kuj tseem tuaj yeem siv rau kev txhim kho ntawm Chav Kawm II tshiab tshiab rau kev kho mob ntshav qab zib mellitus. Meanwhile, nws ua hauj lwm pab raws li ib tug pab chemotherapeutic tus neeg saib xyuas induce apoptosis ntawm qog hlwb, alleviate oxidative puas los ntawm radiotherapy thiab chemotherapy, thiab txo cov mob plawv. Tsis tas li ntawd, ua tsaug rau nws cov tshuaj tua kab mob thiab tiv thaiv kab mob - cov khoom siv inflammatory, mangiferin tuaj yeem tsim rau hauv cov tshuaj pleev thiab qhov ncauj yaug rau kev kho mob dermatitis thiab qhov ncauj qhov ntswg.

Mangiferin Ntxiv

Mangiferintau suav nrog hauv cov npe ntawm cov khoom siv raw khoom zoo los ntawm ntau lub teb chaws thiab tau siv dav hauv cov khoom noj khoom haus rau kev tswj ntshav qab zib, kev tiv thaiv lub siab, tiv thaiv - kev laus thiab kev tiv thaiv kab mob. Nws cov khoom ua tiav hauv qab no tuaj hauv cov ntawv xws li ntsiav tshuaj thiab tshuaj ntsiav. Qhov sib ntxiv ntawm mangiferin rau qis -GI dej qab zib ua haujlwm thiab cov khoom noj siv mis fermented tuaj yeem txo qis glycemic Performance index, ua rau cov khoom no tsim nyog rau cov neeg tswj ntshav qab zib. Compound daim siab- tiv thaiv cov khoom noj qab haus huv feem ntau tsim nrog cov extracts ntawm pueraria thiab silymarin kom txo tau lub siab puas tsuaj los ntawm cawv thiab tshuaj. Los tiv thaiv- laus thiab lub hlwb-Nourishing supplements rau nruab nrab- cov neeg laus thiab cov laus siv nws cov teebmeem neuroprotective los txo oxidative hlwb laus thiab txhim kho kev nco.

Pom zoo ntau npaum li cas ntawm mangiferin sib txawv heev nyob rau hauv ntau daim ntawv thov scenarios. Rau kev noj zaub mov hauv qhov ncauj, tus qauv noj txhua hnub yog li ntawm 100 txog 500 mg. Ib koob tshuaj txhua hnub ntawm 100-300 mg, noj nyob rau hauv 1 mus rau 2 qhov sib faib, feem ntau yog siv rau kev tswj cov ntshav qab zib txhua hnub thiab kev saib xyuas lub siab, thaum cov koob tshuaj tuaj yeem nce mus rau 300-500 mg ib hnub rau kev kho mob metabolic syndrome thiab lub siab puas.

Cov koob tshuaj rau kev npaj tshuaj kho mob tau hloov kho raws li kev coj dawb huv thiab kev kho mob, nrog ntau npaum li 500-1000 mg ib hnub twg tau txais los ntawm kev sim tshuaj ntawm Class II cov tshuaj tshiab; Cov koob tshuaj zoo li no yuav tsum tau noj nyob rau lub sijhawm sib cais raws li kev qhia kho mob kom txo tau qhov mob plab. Rau cov tawv nqaij thiab qhov ncauj npaj, mangiferin yog muab tso rau ntawm ib tug formulation concentration ntawm 0.05% -0.2%.

Qhov ntau npaum li cas qis dua yog siv los hloov tshuaj tua kab mob hauv tsiaj pub: 5-50 grams ntawm mangiferin crude ib tuj pub muab tshuaj tua kab mob antioxidant thiab plab hnyuv- tiv thaiv cov teebmeem.

Hais txog kev nyab xeeb, tib neeg pom zoo luv luv - lub sij hawm ua siab ntev rau cov koob tshuaj txhua hnub nyob rau hauv 1 g, thaum lub sij hawm ntev - kev tswj xyuas tas li tsis raug qhia kom ntau tshaj 800 mg ib hnub twg.

Noj qab haus huv^® tuav ywj siab patented tshuab rau zus tau tej covmangiferin hmoov. Peb cov khoom yog muab rho tawm los ntawm hwm txiv nkhaus taw nplooj ua cov khoom siv raw, featuring ruaj khov purity thiab siab ua haujlwm. Peb qhov zoo tshaj plaws - muag specifications suav nrogdej -soluble 15% mangiferin, nrog rau qib siab -purity qib ntawm60%, 95% thiab 98%. Cov neeg siv khoom tuaj yeem xaiv cov qib tsim nyog hloov pauv raws li lawv tus kheej cov qauv thiab cov kev xav tau ntau lawm rau kev sib txuam.

Peb tau nruab nrog pab pawg R&D kws tshaj lij thiab tus kheej - muaj cov chaw tsim khoom tsim qauv. Los ntawm kev tshem tawm cov neeg faib khoom nruab nrab, peb muaj peev xwm muab kev sib tw thoob ntiaj tebmangiferin nqi. Tag nrho cov ntaub ntawv ua raws li COA (Certificate of Analysis) thiab SDS (Safety Data Sheet) muaj rau txhua pawg. Peb cov khoom tau txais daim ntawv pov thawj suav nrog HACCP zaub mov kev nyab xeeb thiab Halal, ua raws li cov qauv xa tawm thoob ntiaj teb nrog kev ua tau zoo thiab siv dav.

Nrog xyoo dhau los ntawm kev paub txog kev paub txog kev lag luam tawm txawv teb chaws, thov koj xav tias dawbtiv tauj pebntawmhealth@kintaibio.com. Peb yuav muab kev txhawj xeeb rau koj- pub dawb, ua haujlwm tau zoo thiab ruaj khov ntev - lub sijhawm them nyiaj yug.

Cim npe nrov: Mangiferin hmoov, Tuam Tshoj mangiferin hmoov manufacturers, lwm tus neeg, Hoobkas