Indole-3-carbinol hmoov

Noj qab haus huv^® yog aTuam Tshoj 3-indole-3-carbinol manufacturers thiab lwm tus neeg. I3C yog ib qho tshwm sim bioactive phytochemical pom nyob rau hauv cov zaub cruciferous (xws li broccoli, zaub qhwv, thiab kale). Nyob rau hauv cov nroj tsuag hlwb, nws muaj nyob rau hauv precursor daim ntawv thiab yog tsim los ntawm enzymatic hydrolysis thaum cov zaub yog tws los yog chewed. Ntau qhov kev tshawb fawb tshawb fawb tau pom tiasI3Cthiab nws cov metabolites tuaj yeem tswj hwm ntau txoj hauv kev tseem ceeb hauv lub cev, suav nrog antioxidant, tiv thaiv -inflammatory, estrogen metabolism hauv kev tswj hwm, thiab detoxification enzyme induction. Yog li ntawd, nws muaj kev siv dav hauv kev kho mob qog noj ntshav thiab ua cov khoom noj ntxiv.Tiv tauj pebntawminfo@kintaibio.com.

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Pib Cov Khoom Siv thiab Kev Npaj Reagent

Indole tau siv los ua cov khoom pib. N, N-dimethylformamide (DMF), phosphorus oxychloride (POCl₃), sodium borohydride (NaBH₄), ethanol, dichloromethane, sodium hydroxide, dilute hydrochloric acid, thiab dej ntshiab tau npaj. Cov khoom siv tshuaj tiv thaiv thiab lub tshuab nqus tsev ziab kom huv si kom huv si thiab ua haujlwm.

Formylation Synthesis ntawm Indole-3-Carbaldehyde

DMF tau ntxiv rau hauv cov hlab ntsha qhuav thiab nplawm thaum txias. Phosphorus oxychloride yog tom qab ntawd maj mam ntxiv dropwise, ua raws li kev sib txuas ntxiv los tsim Vilsmeier reagent. Tom qab ntawd Indole tau yaj hauv ib qho me me ntawm DMF thiab maj mam ntxiv dropwise rau cov tshuaj tiv thaiv. Tom qab txias rau chav sov, cov tshuaj tiv thaiv tau maj mam hliv rau hauv dej khov - dej sib tov rau hydrolysis. Cov pH tau hloov kho rau 7-8 nrog 30% sodium hydroxide tov, ua rau cov nag lossis daus loj ntawm cov khoom daj. Cov khoom no tau lim, ntxuav nrog dej kom txog thaum nruab nrab, thiab qhuav kom tau txais cov hmoov txhuv nplej siab indole-3-carbaldehyde.

Synthesis ntawm Crude 3-Indolemethylethanol

Indole-3-carboxaldehyde tau yaj hauv methanol lossis ethanol thiab nplawm kom txog thaum yaj tag. Cov tshuaj tau muab tso rau hauv ib da dej dej khov ntawm 0-5 degree, thiab sodium borohydride tau ntxiv rau hauv cov khoom siv. Tom qab cov tshuaj tiv thaiv tiav lawm, dilute hydrochloric acid los yog saturated ammonium chloride tov tau maj mam ntxiv kom txo qis tus neeg sawv cev thiab kho cov pH mus rau 7. Feem ntau ntawm cov cawv hnyav ces muab tshem tawm los ntawm lub tshuab nqus tsev distillation. Cov seem tau muab rho tawm 2-3 zaug nrog ethyl acetate lossis dichloromethane. Cov txheej txheem sib xyaw ua ke tau qhuav dhau los ntawm anhydrous sodium sulfate, lim, thiab tom qab ntawd distilled nyob rau hauv lub tshuab nqus tsev kom tau txais ib qho dawb mus rau-dawb crude 3-indolemethylethanol.

Purification kom tau txais cov khoom kawg

Lub crude 3-indolemethylethanol tau yaj nyob rau hauv ib tug haum npaum li cas ntawm kub ethanol- dej sib tov hnyav kom txog rau thaum tsuas yog yaj. Cov tshuaj tau lim thaum kub kom tshem tawm cov teeb meem insoluble. Cov filtrate tau maj mam txias rau hauv chav sov thiab tom qab ntawd muab tso rau hauv ib da dej dej khov kom cia cov muaju los nyob. Cov crystals tau sau los ntawm lub tshuab nqus tsev pom thiab ntxuav nrog me me ntawm cov kuab tshuaj txias. Thaum kawg, cov tshuaj tau qhuav nyob rau hauv lub tshuab nqus tsev ntawm 40-50℃kom tau ib tug high-purity 3-indolemethylethanol khoom nrog ib tug purity ntawm ntau tshaj 99%.

3-Indolemethyl (I3C)yog ib qho tshwm sim tshwm sim precursor compound pom nyob rau hauv cruciferous zaub, thaum3,3' -diindolylmethane (DIM)yog lub ntsiab metabolite tsim los ntawm condensation cov tshuaj tiv thaiv ntawm I3C nyob rau hauv acidic ib puag ncig ntawm lub plab. Ob qhov sib txawv hauv lawv cov qauv tshuaj:I3C yog monomer (muaj ib pawg hydroxymethyl), thaumDIMyog ib tug dimer (tsim los ntawm condensation ntawm ob I3C molecules thiab tsis muaj ib pawg hydroxymethyl).

Qhov tseem ceeb tshaj qhov zoo ntawmDIMyog nws cov tshuaj stability. I3C tau hloov pauv sai hauv cov kua qaub hauv plab, ua rau yuav luag tsis tuaj yeem kuaj tsis tau hloov pauv I3C hauv ntshav tom qab kev tswj hwm qhov ncauj; Hauv qhov sib piv, DIM tseem nyob ruaj khov hauv qhov chaw acidic thiab tuaj yeem nqus tau rau hauv cov hlab ntsha hauv nws daim ntawv tsis zoo. Qhov no txhais tau hais tias DIM muaj ntau dua qhov ncauj bioavailability duaI3C, ua rau nws tsim nyog rau formulation raws li qhov ncauj ntxiv, thiab nws nyob rau hauv vivo cov teebmeem yog kwv yees ntau dua.

VimI3C lojyog tsis ruaj tsis khov nyob rau hauv lub acidic ib puag ncig ntawm lub plab thiab sai converts mus rau hauvDIMthiab lwm yam oligomers, nws tuaj yeem ua lub luag haujlwm tshwj xeeb hauv zos hauv plab hnyuv. Piv txwv li, hauv chemoprevention ntawm cov kab mob plab xws li mob qog noj ntshav hauv plab, qhov siab ntawm cov metabolites nquag ua hauv zos hauv plab thiab cov hnyuv los ntawm I3C tuaj yeem ua tau zoo dua.DIM.

3-Indolemethylethanol (I3C) thiab sulforaphaneyog ob qho tib si tseem ceeb bioactive phytochemicals pom nyob rau hauv cruciferous zaub (xws li broccoli, zaub qhwv, thiab kale), tab sis lawv pib los ntawm ntau qhov chaw: I3C tus precursor yog glucobrassicin, ib hom glucosinolate, thaum.sulforaphaneLub precursor yog glucoraphanin. Ob leeg xav tau hydrolysis los ntawm myrosinase los tsim lawv cov ntaub ntawv nquag.

Txawm hais tias lawv cov qauv tshuaj sib txawv kiag li, lawv sib tshooj sib tshooj tseem ua haujlwm sib txawv: ob qho tib si tuaj yeem qhib txoj hauv kev Nrf2, inducing qhia txog theem II detoxification enzymes, yog li exerting antioxidant thiab chemopreventive teebmeem; tib lub sijhawm, ob leeg tuaj yeem tswj hwm aryl hydrocarbon receptor (AhR) kev ua haujlwm. Txawm li cas los xij, sulforaphane tam sim no tau lees paub tias yog ib qho muaj zog tshaj plaws Nrf2 activators, thaumI3C (thiab nws cov metabolite DIM)Nws feem ntau yog tus cwj pwm los ntawm nws cov kev cai ntawm cov tshuaj estrogen metabolism.

indole-3-carbinol pab kev poob phaus

I3C nthuav qhia meej ntau- txoj hauv kev muaj peev xwm nyob hauvpoob phaus. Cov kev sim tsiaj tau lees paub tias nws tuaj yeem txo lub cev hnyav, rog rog, thiab mob siab steatosis hauv siab - noj zaub mov rog - ntxias cov nas rog rog, thiab txhim kho cov tshuaj insulin thiab cov kab mob hauv lub cev. Tsis tas li ntawd, I3C tuaj yeem txo lipogenesis los ntawm inhibiting FTO protein qhia nyob rau hauv adipocytes, txhim kho hyperleptinemia los ntawm alleviating endoplasmic reticulum kev nyuaj siab, thiab tswj cov metabolites xws li arginine succinate, yog li exerting anti{5}} rog los ntawm ntau qhov ntev.

Indole 3 carbinol hormone tshuav nyiaj li cas

Indole 3 Carbinol hmoovFeem ntau tswj cov tshuaj hormones los ntawmestrogen metabolism, uas yog ib qho ntawm nws cov kev ua ub no nyob ze tshaj plaws. I3C txhawb kev hloov pauv ntawm estrone (E1) thiab estradiol (E2) mus rau kev tiv thaiv 2-hydroxyestrone metabolic txoj kev, thaum inhibiting zus tau tej cov genotoxic 4-hydroxyestrone thiab 16 -hydroxyestrone. Cov tshuaj estrogen-biased metabolic no tuaj yeem pab txo qhov kev pheej hmoo ntawm cov qog nqaij hlav estrogen. Tsis tas li ntawd,I3C hmoovtuaj yeem cuam tshuam rau lwm cov tshuaj hormones metabolic los ntawm kev tswj hwm aryl hydrocarbon receptors (AhRs) thiab tuaj yeem cuam tshuam qhov sib npaug ntawm cov thyroid hormones; Txawm li cas los xij, tom kawg yuav tsum tau saib xyuas thaum noj tshuaj ntau.

indole 3 carbinol cov txiaj ntsig rau txiv neej

Cov teebmeem ntawm I3C ntawm cov txiv neejFeem ntau tsom rau ob yam: kev tswj cov tshuaj estrogen thiab kev noj qab haus huv ntawm prostate.I3C hmoovpab txo lub peev xwm stimulating nyhuv ntawm estrogen ntawm prostate, exerting ib tug chemopreventive nyhuv. Tsis tas li ntawd, cov kev tshawb fawb ua ntej qhia tau hais tias I3C kuj tseem yuav muaj kev cuam tshuam zoo rau txiv neej kev laus kev noj qab haus huv (xws li kev txhim kho cov phev zoo) los ntawm kev tswj hwm aryl hydrocarbon receptors (AhR) thiab tiv thaiv - txoj hauv kev. Nws yog ib qho tseem ceeb kom nco ntsoov tiasloj I3Ctsis yog tshuaj tiv thaiv -androgen thiab tsis txo qis testosterone qib; es, nws indirectly tswj cov txiv neej endocrine homeostasis los ntawm regulatingestrogen tshuav nyiaj li cas.

indole 3 carbinol lub cev tsim

Kev tshawb fawb tam sim no ntawm cov teebmeem ntawm3-Indolemethylethanol (I3C)hauv kev txo cov rog thiab kev tswj hwm cov metabolism hauv kev tsis ncaj ncees txhawb kev txhim kho hauv lub cev. I3C tuaj yeem inhibit qhov kev qhia ntawm FTO protein nyob rau hauv adipocytes, txo cov roj ntau lawm. Cov teebmeem no pab txo qis tag nrho lub cev rog feem pua, ua rau lub cev hnyav dua. Txawm li cas los xij, I3C tsis muaj lub hom phiaj ntawm kev ua haujlwm hauv cheeb tsam (xws li kev txo qis hauv duav thiab lub plab lossiscov leeg nce); Nws cov teebmeem tau tshwm sim ntau dua hauv kev txo qis hauv lub cev rog tau ua tiav los ntawm kev txhim kho metabolic. Thaum ua ke nrog kev tawm dag zog tas li thiab noj cov protein ntau, I3C tuaj yeem, rau qee qhov, pab txhim kho lub cev muaj pes tsawg leeg.

indole 3 carbinol plaub hau poob

Cov kev tshawb fawb tau qhia tias3-Indolemethylethanol (I3C)tej zaum yuav muaj peev xwm siv hauv kev tiv thaiv thiab kho cov plaub hau poob los ntawm kev tswj cov tshuaj hormones thiab txhim kho cov tawv taub hau ib puag ncig. Cov tshuaj tua kab mob antioxidant thiab tiv thaiv - cov khoom ua kom mob ntawm I3C pab txhim kho cov tawv nqaij microenvironment, uas muaj peev xwm cuam tshuam tus nqi rau androgenetic alopecia. Covcov teebmeem ntawm I3Cntawm cov plaub hau poob feem ntau yog nyob ib puag ncig tiv thaiv-oxidation, tiv thaiv- mob, thiab kev tswj hwm cov tshuaj hormones, qhia tshwj xeeb rau seborrheic alopecia thiab androgenetic alopecia; Txawm li cas los xij, tam sim no nws yuav tsum raug suav hais tias yog kev cuam tshuam ntxiv es tsis yog kev hloov kho.

Indole 3 carbinol Nyob rau hauv kws

Hauv tshuaj,3-indoleethanol (I3C)tau tsim los ua ntau hom tshuaj kom tau raws li kev xav tau ntawm kev kho mob sib txawv thiab txhim kho bioavailability. Cov ntaub ntawv ntau npaum li cas yog cov ntaub ntawv ntawm qhov ncauj khoom noj, nrog rau tsis tu ncuacapsules, ntsiav tshuaj, thiab suav nrog cov complexes npaj siv cyclodextrin inclusion technology, uas tuaj yeem txhim kho qhov ruaj khov ntawm I3C hauv gastric acid. Tsis tas li ntawd, cov tshuaj pleev ib ce xws li cream thiab gels kuj tau tshawb nrhiav rau kev kho mob hauv zos ntawm cov kab mob ntawm daim tawv nqaij.

indole 3 carbinol ntxiv

Daim ntawv thov ntawmbulk I3C hmoovCov tshuaj ntxiv feem ntau tsom rau ob qhov chaw:tshuaj estrogenkev txhawb nqa metabolism thiab kev tiv thaiv cell noj qab haus huv. I3C feem ntau pom nyob rau hauvindole 3 carbinol ntsiav tshuaj, tshuaj ntsiavdaim ntawv nyob rau hauv cov tshuaj pab kho mob, nrog rau ib zaug - tshuaj ntsiav tshuaj ntau npaum li ntawm 150mg txog 400mg. Cov khoom lag luam muaj feem ntau ua ke nrog resveratrol, linolenic acid, lossis cruciferous zaub extracts los txhim kho cov teebmeem. Nws yog ib qho tseem ceeb kom nco ntsoov tias nws yog contraindicated nyob rau hauv cov poj niam cev xeeb tub thiab pub niam mis, thiab cov tam sim no noj cov tshuaj no yuav tsum tau mus ntsib kws kho mob ua ntej siv.

Raws li cov ntaub ntawv tshawb fawb soj ntsuam uas twb muaj lawm, feem ntau siv tshuaj ntxiv rau3-Indole-3-Carbinolnyob rau hauv tib neeg sim yog50 mg rau 400 mgtxhua hnub . 200 mg txhua hnub yog suav tias yog kev saib xyuas ntau dua pib koob tshuaj, feem ntau siv luv luv - mus rau nruab nrab- cov kev tshawb fawb txog kev cuam tshuam; thaum 400 mg ib hnub yog siv raws li tus qauv koob tshuaj ntau dua rau hauv - ntsuas qhov tob ntawm cov cim qhia lub cev. Ob koob tshuaj no (200 mg thiab 400 mg ntawm Indole-3-Carbinol) yog cov kev qhia ntau tshaj plaws hauv cov ntaub ntawv. Nws yog ib qho tseem ceeb kom paub meej tias US Food and Drug Administration (FDA) tsis tau pom zoo 3-indole-3-Carbinol rau kev siv tshuaj; Yog li ntawd, cov koob tshuaj saum toj no tsuas yog muaj ntau yam hauv kev tshawb fawb soj ntsuam thiab tsis yog cov qauv kev kho mob raug cai.

Hais txog lubkev nyab xeeb thiab kev phiv ntawm l3C, ntau qhov kev tshawb fawb pom zoo qhia tau hais tias qhov sib xyaw no feem ntau ua tau zoo - zam ntawm cov tshuaj noj ib txwm. Hauv tib neeg cov kev tshawb fawb soj ntsuam, koob tshuaj txhua hnub ntawm 200-400 mg rau 4 lub lis piam mus rau ob peb lub hlis tsis pom muaj qhov cuam tshuam loj heev; tsuas yog ob peb tus neeg siv tau tshaj tawm me ntsis nce hauv plab hnyuv motility los yog nyem ntawm cem quav. Hauv 5-xyoo kev soj ntsuam, cov neeg mob noj kwv yees li 300 mg / hnub qhia tsis muaj qhov tseem ceebkev mob tshwm sim. Lwm cov kev mob tshwm sim muaj xws li qee zaus ntawm daim tawv nqaij ua pob khaus thiab plab hnyuv tsis xis nyob.

Xaiv peb99% 3-indolemethylethanol hmoov. Peb ntiav cov txheej txheem tshuaj lom neeg ua kom paub tab thiab ethanol-dej recrystallization thev naus laus zis kom tsis txhob muaj teeb meem hnyav hnyav xws li benzene lossis toluene, ua kom peb cov khoom ua tau raws li cov qauv hlau hnyav thoob ntiaj teb thiab microbiological. Txhua pawg tuaj nrog Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (COA). Peb muaj peev xwm muab khoom ruaj khov txij li kilograms mus rau tons, txhawb kev tsim kho raws li qhov loj me thiab ntim cov specifications. Peb tuaj yeem muab 10g cov qauv rau R & D kuaj. Tsis tas li ntawd, peb muab kev txhawb nqa tag nrho, pab nrog kev tsim qauv thiab kev tshawb fawb kev ruaj ntseg. Peb qhov system zoo yog ISO9001 tau ntawv pov thawj.Tiv tauj pebntawminfo@kintaibio.com.

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